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Arrdc4 arrestin domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 66412, updated on 11-Apr-2024

Summary

Official Symbol
Arrdc4provided by MGI
Official Full Name
arrestin domain containing 4provided by MGI
Primary source
MGI:MGI:1913662
See related
Ensembl:ENSMUSG00000042659 AllianceGenome:MGI:1913662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410003C09Rik
Summary
Enables ubiquitin ligase-substrate adaptor activity. Involved in extracellular vesicle biogenesis; protein transport; and protein ubiquitination. Located in extracellular vesicle and plasma membrane. Orthologous to human ARRDC4 (arrestin domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.0), colon adult (RPKM 8.7) and 28 other tissues See more
Orthologs
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Genomic context

See Arrdc4 in Genome Data Viewer
Location:
7 C; 7 37.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (68386742..68398986, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (68736994..68749238, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34549 Neighboring gene STARR-seq mESC enhancer starr_19116 Neighboring gene tetraspanin 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19117 Neighboring gene STARR-seq mESC enhancer starr_19119 Neighboring gene STARR-seq mESC enhancer starr_19120 Neighboring gene STARR-seq mESC enhancer starr_19121 Neighboring gene predicted gene, 34612 Neighboring gene predicted gene, 34664 Neighboring gene STARR-seq mESC enhancer starr_19123

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like ligase-substrate adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
arrestin domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042592.2NP_001036057.1  arrestin domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001036057.1

    Status: VALIDATED

    Source sequence(s)
    AK037198, AV245884, BY738896
    Consensus CDS
    CCDS39985.1
    UniProtKB/Swiss-Prot
    A0A0B4J1F4, Q8VD69
    UniProtKB/TrEMBL
    Q0GJK1
    Related
    ENSMUSP00000044578.8, ENSMUST00000048068.15
    Conserved Domains (2) summary
    smart01017
    Location:188315
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19166
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_025549.3NP_079825.2  arrestin domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_079825.2

    Status: VALIDATED

    Source sequence(s)
    AK010352, AK037198, BY738896
    Consensus CDS
    CCDS52272.1
    UniProtKB/TrEMBL
    Q9D6S6
    Related
    ENSMUSP00000112962.2, ENSMUST00000118110.3
    Conserved Domains (2) summary
    smart01017
    Location:188292
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:23166
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    68386742..68398986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)