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ARRDC4 arrestin domain containing 4 [ Homo sapiens (human) ]

Gene ID: 91947, updated on 13-Mar-2020

Summary

Official Symbol
ARRDC4provided by HGNC
Official Full Name
arrestin domain containing 4provided by HGNC
Primary source
HGNC:HGNC:28087
See related
Ensembl:ENSG00000140450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See ARRDC4 in Genome Data Viewer
Location:
15q26.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (97960703..97973833)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (98503933..98517068)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927310 Neighboring gene uncharacterized LOC105371007 Neighboring gene long intergenic non-protein coding RNA 923 Neighboring gene uncharacterized LOC105371009 Neighboring gene long intergenic non-protein coding RNA 2251 Neighboring gene RNA, U6 small nuclear 1186, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of neuroticism in a population-based sample.
NHGRI GWA Catalog
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of arrestin domain containing 4 (ARRDC4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging involved in substrate recognition for ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
extracellular vesicle biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ubiquitin-protein transferase activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
early endosome IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arrestin domain-containing protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183376.3NP_899232.2  arrestin domain-containing protein 4

    See identical proteins and their annotated locations for NP_899232.2

    Status: VALIDATED

    Source sequence(s)
    AA872967, AC024651, AK290221, BC038453, BC070100, BY797927, DB089068
    Consensus CDS
    CCDS10377.1
    UniProtKB/Swiss-Prot
    Q8NCT1
    UniProtKB/TrEMBL
    A0A024RC80, A8K2F6
    Related
    ENSP00000268042.6, ENST00000268042.7
    Conserved Domains (2) summary
    smart01017
    Location:191318
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:26169
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    97960703..97973833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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