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ARRDC4 arrestin domain containing 4 [ Homo sapiens (human) ]

Gene ID: 91947, updated on 23-Nov-2023

Summary

Official Symbol
ARRDC4provided by HGNC
Official Full Name
arrestin domain containing 4provided by HGNC
Primary source
HGNC:HGNC:28087
See related
Ensembl:ENSG00000140450 MIM:619788; AllianceGenome:HGNC:28087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Acts upstream of or within positive regulation of ubiquitin-protein transferase activity. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 14.4) and 25 other tissues See more
Orthologs
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Genomic context

See ARRDC4 in Genome Data Viewer
Location:
15q26.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (97960703..97973833)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (95726358..95739492)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (98503933..98517063)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 923 Neighboring gene MPRA-validated peak2442 silencer Neighboring gene uncharacterized LOC124903585 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:98513642-98514841 Neighboring gene uncharacterized LOC105371009 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:98547297-98547798 Neighboring gene long intergenic non-protein coding RNA 2251 Neighboring gene uncharacterized LOC124903587

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of neuroticism in a population-based sample.
EBI GWAS Catalog
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of arrestin domain containing 4 (ARRDC4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ36045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in extracellular vesicle biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arrestin domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183376.3NP_899232.2  arrestin domain-containing protein 4

    See identical proteins and their annotated locations for NP_899232.2

    Status: VALIDATED

    Source sequence(s)
    AA872967, AC024651, AK290221, BC038453, BC070100, BY797927, DB089068
    Consensus CDS
    CCDS10377.1
    UniProtKB/Swiss-Prot
    Q6NSI9, Q8NCT1
    UniProtKB/TrEMBL
    A8K2F6
    Related
    ENSP00000268042.6, ENST00000268042.7
    Conserved Domains (2) summary
    smart01017
    Location:191318
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:26169
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    97960703..97973833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    95726358..95739492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)