Rsl1d1 ribosomal L1 domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rsl1d1provided by MGI
Official Full Name: ribosomal L1 domain containing 1provided by MGI
Primary source: MGI:MGI:1913659
See related: Ensembl:ENSMUSG00000005846 AllianceGenome:MGI:1913659
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: pBK1; 2410005K20Rik
Summary: Predicted to enable mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to be involved in maturation of LSU-rRNA; regulation of apoptotic process; and regulation of cellular senescence. Predicted to act upstream of or within regulation of protein localization. Located in nucleolus. Is expressed in several structures, including eye; genitourinary system; liver; lung; and spleen. Orthologous to human RSL1D1 (ribosomal L1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 40.8), liver E14 (RPKM 32.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16; 16 A1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (11010901..11021156, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (11193037..11203292, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RSL1D1 modulates cell senescence and proliferation via regulation of PPARgamma mRNA stability.
Title: RSL1D1 modulates cell senescence and proliferation via regulation of PPARγ mRNA stability.
Conclusively, both ribosomal L1 domain and Lys-rich region of CSIG are critical for CSIG to act as a regulator of cell proliferation and cellular senescence.
Title: Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C76439 (e-PCR)
- UniSTS:160524

15.MMHAP88FRE9.seq (e-PCR)
- UniSTS:123277

Homology

Homologs of the Rsl1d1 gene: The Rsl1d1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 493 organisms have orthologs with human gene Rsl1d1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
part_of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal L1 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.