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Nosip nitric oxide synthase interacting protein [ Mus musculus (house mouse) ]

Gene ID: 66394, updated on 2-Nov-2024

Summary

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Official Symbol
Nosipprovided by MGI
Official Full Name
nitric oxide synthase interacting proteinprovided by MGI
Primary source
MGI:MGI:1913644
See related
Ensembl:ENSMUSG00000003421 AllianceGenome:MGI:1913644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-25; 2310061K06Rik
Summary
Predicted to enable molecular sequestering activity. Predicted to be involved in negative regulation of nitric-oxide synthase activity and regulation of nitric oxide biosynthetic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain and cerebral cortex. Used to study holoprosencephaly. Orthologous to human NOSIP (nitric oxide synthase interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 33.0), thymus adult (RPKM 26.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nosip in Genome Data Viewer
Location:
7 B3; 7 29.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44711840..44727927)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45062417..45078503)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene proline rich 12 Neighboring gene STARR-positive B cell enhancer ABC_E6541 Neighboring gene STARR-positive B cell enhancer ABC_E2235 Neighboring gene proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840 Neighboring gene reticulocalbin 3, EF-hand calcium binding domain Neighboring gene Fc fragment of IgG receptor and transporter

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nosip functions during vertebrate eye and cranial cartilage development. Flach H, et al. Dev Dyn, 2018 Sep. PMID 30055071
  2. Developmental neurogenesis in mouse and Xenopus is impaired in the absence of Nosip. Hoffmeister M, et al. Dev Biol, 2017 Sep 1. PMID 28663132
  3. The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. Hoffmeister M, et al. PLoS One, 2014. PMID 25546391, Free PMC Article
  4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC115777

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular sequestering activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nitric oxide synthase-interacting protein
Names
E3 ubiquitin-protein ligase NOSIP
RING-type E3 ubiquitin transferase NOSIP
NP_001157156.1
NP_079809.1
XP_017167721.1
XP_030098752.1
XP_036009246.1
XP_036009247.1
XP_036009248.1
XP_036009249.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163684.1 → NP_001157156.1  nitric oxide synthase-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_001157156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC126256, AK007962, DV648837
    Consensus CDS
    CCDS52242.1
    UniProtKB/Swiss-Prot
    Q9D6T0
    Related
    ENSMUSP00000103460.3, ENSMUST00000107829.9
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:195 → 259
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  2. NM_025533.3 → NP_079809.1  nitric oxide synthase-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_079809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC126256, BC089029, DV648837
    Consensus CDS
    CCDS21228.1
    UniProtKB/Swiss-Prot
    Q9D6T0, Q9D8J9
    Related
    ENSMUSP00000003513.4, ENSMUST00000003513.11
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220 → 284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44711840..44727927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153353.1 → XP_036009246.1  nitric oxide synthase-interacting protein isoform X2

    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:218 → 282
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  2. XM_017312232.2 → XP_017167721.1  nitric oxide synthase-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    Q9D6T0, Q9D8J9
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220 → 284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  3. XM_030242892.1 → XP_030098752.1  nitric oxide synthase-interacting protein isoform X3

    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:195 → 259
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  4. XM_036153355.1 → XP_036009248.1  nitric oxide synthase-interacting protein isoform X4

    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:193 → 257
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  5. XM_036153354.1 → XP_036009247.1  nitric oxide synthase-interacting protein isoform X2

    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:218 → 282
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  6. XM_036153356.1 → XP_036009249.1  nitric oxide synthase-interacting protein isoform X4

    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:193 → 257
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6T0.1 GenPept UniProtKB/Swiss-Prot:Q9D6T0

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