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NOSIP nitric oxide synthase interacting protein [ Homo sapiens (human) ]

Gene ID: 51070, updated on 23-Nov-2023

Summary

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Official Symbol
NOSIPprovided by HGNC
Official Full Name
nitric oxide synthase interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:17946
See related
Ensembl:ENSG00000142546 MIM:616759; AllianceGenome:HGNC:17946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-25
Summary
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in testis (RPKM 21.1), lymph node (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

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See NOSIP in Genome Data Viewer
Location:
19q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49555468..49580556, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52555474..52580588, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50058725..50083813, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50017428-50018141 Neighboring gene Fc gamma receptor and transporter Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50031176-50031754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10920 Neighboring gene reticulocalbin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50059309-50060090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14948 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50070496-50070674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50087865-50088490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10923 Neighboring gene proline rich and Gla domain 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10924 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50095111-50095610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10925 Neighboring gene proline rich 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs's disease. Tomuschat C, et al. J Pediatr Surg, 2017 May. PMID 28196663
  2. Cellular signaling and NO production. Michel T, et al. Pflugers Arch, 2010 May. PMID 20082095, Free PMC Article
  3. Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein. Pörschke M, et al. J Biol Chem, 2023 Mar. PMID 36690276, Free PMC Article
  4. nNOS induction and NOSIP interaction impact granulopoiesis and neutrophil differentiation by modulating nitric oxide generation. Sadaf S, et al. Biochim Biophys Acta Mol Cell Res, 2021 Jun. PMID 33771575
  5. Erythropoietin receptors associate with a ubiquitin ligase, p33RUL, and require its activity for erythropoietin-induced proliferation. Friedman AD, et al. J Biol Chem, 2003 Jul 18. PMID 12746455

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.
    Title: Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein.
  2. nNOS induction and NOSIP interaction impact granulopoiesis and neutrophil differentiation by modulating nitric oxide generation.
    Title: nNOS induction and NOSIP interaction impact granulopoiesis and neutrophil differentiation by modulating nitric oxide generation.
  3. While NOSIP expression was increased in Hirschsprung's disease (HSCR) vs. non- HSCR patients, no significant difference was observed in patients with Hirschsprung's associated enterocolitis. The increased expression of NOSIP in the aganglionic and ganglionic bowel of HSCR may contribute to the development of enterocolitis by inhibiting local nitric oxide production in patients with Hirschsprung's disease.
    Title: NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs's disease.
  4. Endogenous NOSIP reduces the enzymatic capacity of eNOS, specifically in the G(2) phase of the cell cycle by targeting eNOS to the actin cytoskeleton.
    Title: Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.
  5. endothelial nitric oxide synthase (eNOS) interacting protein (NOSIP), modulator of eNOS activity by alteration of eNOS subcellular localisation; high expression levels in endothelial cells and vascularized tissue.
    Title: NOSIP, a novel modulator of endothelial nitric oxide synthase activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables molecular sequestering activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nitric oxide synthase-interacting protein
Names
E3 ubiquitin-protein ligase NOSIP
RING-type E3 ubiquitin transferase NOSIP
eNOS-interacting protein
NP_001257889.1
NP_001350578.1
NP_057037.1
XP_005259021.1
XP_011525317.1
XP_011525319.1
XP_016882340.1
XP_016882341.1
XP_047294851.1
XP_047294852.1
XP_054177115.1
XP_054177116.1
XP_054177117.1
XP_054177118.1
XP_054177119.1
XP_054177120.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270960.2 → NP_001257889.1  nitric oxide synthase-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001257889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC009299, BE826708, DB470916
    Consensus CDS
    CCDS12772.1
    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
    Related
    ENSP00000470034.1, ENST00000596358.6
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220 → 284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  2. NM_001363649.2 → NP_001350578.1  nitric oxide synthase-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010619, AI311486, BC010077, BE786274, DB470916
    Consensus CDS
    CCDS86789.1
    UniProtKB/TrEMBL
    A0A075B6F9, A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:223 → 287
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  3. NM_015953.5 → NP_057037.1  nitric oxide synthase-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_057037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC010077, BE826708, DB470916
    Consensus CDS
    CCDS12772.1
    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220 → 284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49555468..49580556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258964.6 → XP_005259021.1  nitric oxide synthase-interacting protein isoform X2

    See identical proteins and their annotated locations for XP_005259021.1

    UniProtKB/TrEMBL
    A0A075B6F9, A8K670
    Related
    ENSP00000343497.3, ENST00000339093.7
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:223 → 287
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  2. XM_017026851.2 → XP_016882340.1  nitric oxide synthase-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220 → 284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  3. XM_047438895.1 → XP_047294851.1  nitric oxide synthase-interacting protein isoform X2

    UniProtKB/TrEMBL
    A0A075B6F9, A8K670

  4. XM_017026852.2 → XP_016882341.1  nitric oxide synthase-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:4 → 78
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220 → 284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

  5. XM_011527017.3 → XP_011525319.1  nitric oxide synthase-interacting protein isoform X4

    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:5 → 79
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cl17238
    Location:151 → 277
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  6. XM_011527015.3 → XP_011525317.1  nitric oxide synthase-interacting protein isoform X1

    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:5 → 79
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cl17238
    Location:154 → 280
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  7. XM_047438896.1 → XP_047294852.1  nitric oxide synthase-interacting protein isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52555474..52580588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321141.1 → XP_054177116.1  nitric oxide synthase-interacting protein isoform X2

    UniProtKB/TrEMBL
    A0A075B6F9, A8K670

  2. XM_054321142.1 → XP_054177117.1  nitric oxide synthase-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670

  3. XM_054321144.1 → XP_054177119.1  nitric oxide synthase-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670

  4. XM_054321143.1 → XP_054177118.1  nitric oxide synthase-interacting protein isoform X4

    UniProtKB/TrEMBL
    A8K670

  5. XM_054321140.1 → XP_054177115.1  nitric oxide synthase-interacting protein isoform X1

    UniProtKB/TrEMBL
    A8K670

  6. XM_054321145.1 → XP_054177120.1  nitric oxide synthase-interacting protein isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y314.1 GenPept UniProtKB/Swiss-Prot:Q9Y314