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NOSIP nitric oxide synthase interacting protein [ Homo sapiens (human) ]

Gene ID: 51070, updated on 10-Oct-2020

Summary

Official Symbol
NOSIPprovided by HGNC
Official Full Name
nitric oxide synthase interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:17946
See related
Ensembl:ENSG00000142546 MIM:616759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-25
Summary
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in testis (RPKM 21.1), lymph node (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See NOSIP in Genome Data Viewer
Location:
19q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49555468..49580556, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50058725..50083845, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Fc fragment of IgG receptor and transporter Neighboring gene reticulocalbin 3 Neighboring gene proline rich and Gla domain 2 Neighboring gene proline rich 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nitric oxide synthase-interacting protein
Names
E3 ubiquitin-protein ligase NOSIP
RING-type E3 ubiquitin transferase NOSIP
eNOS-interacting protein
NP_001257889.1
NP_001350578.1
NP_057037.1
XP_005259021.1
XP_011525317.1
XP_011525319.1
XP_016882340.1
XP_016882341.1
XP_024307296.1
XP_024307297.1
XP_024307298.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270960.2NP_001257889.1  nitric oxide synthase-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001257889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC009299, BE826708, DB470916
    Consensus CDS
    CCDS12772.1
    UniProtKB/Swiss-Prot
    Q9Y314
    Related
    ENSP00000470034.1, ENST00000596358.6
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  2. NM_001363649.2NP_001350578.1  nitric oxide synthase-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010619, AI311486, BC010077, BE786274, DB470916
    Consensus CDS
    CCDS86789.1
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:223287
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  3. NM_015953.5NP_057037.1  nitric oxide synthase-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_057037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC010077, BE826708, DB470916
    Consensus CDS
    CCDS12772.1
    UniProtKB/Swiss-Prot
    Q9Y314
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49555468..49580556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451529.1XP_024307297.1  nitric oxide synthase-interacting protein isoform X2

    Conserved Domains (3) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:266330
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
    cl28033
    Location:138281
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  2. XM_005258964.5XP_005259021.1  nitric oxide synthase-interacting protein isoform X4

    See identical proteins and their annotated locations for XP_005259021.1

    UniProtKB/TrEMBL
    A0A075B6F9
    Related
    ENSP00000343497.3, ENST00000339093.7
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:223287
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  3. XM_017026851.1XP_016882340.1  nitric oxide synthase-interacting protein isoform X5

    UniProtKB/Swiss-Prot
    Q9Y314
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  4. XM_024451530.1XP_024307298.1  nitric oxide synthase-interacting protein isoform X2

    Conserved Domains (3) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:266330
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
    cl28033
    Location:138281
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  5. XM_017026852.1XP_016882341.1  nitric oxide synthase-interacting protein isoform X5

    UniProtKB/Swiss-Prot
    Q9Y314
    Related
    ENSP00000473109.1, ENST00000599537.5
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  6. XM_011527017.2XP_011525319.1  nitric oxide synthase-interacting protein isoform X6

    Conserved Domains (2) summary
    pfam15906
    Location:579
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cl17238
    Location:151277
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  7. XM_024451528.1XP_024307296.1  nitric oxide synthase-interacting protein isoform X1

    Conserved Domains (3) summary
    pfam15906
    Location:579
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:267331
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
    cl28033
    Location:139282
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  8. XM_011527015.2XP_011525317.1  nitric oxide synthase-interacting protein isoform X3

    Conserved Domains (2) summary
    pfam15906
    Location:579
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cl17238
    Location:154280
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
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