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NOSIP nitric oxide synthase interacting protein [ Homo sapiens (human) ]

Gene ID: 51070, updated on 3-May-2025
Official Symbol
NOSIPprovided by HGNC
Official Full Name
nitric oxide synthase interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:17946
See related
Ensembl:ENSG00000142546 MIM:616759; AllianceGenome:HGNC:17946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-25
Summary
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in testis (RPKM 21.1), lymph node (RPKM 12.2) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table
See NOSIP in Genome Data Viewer
Location:
19q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49555468..49580556, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52555474..52580588, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50058725..50083813, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50017428-50018141 Neighboring gene Fc gamma receptor and transporter Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50031176-50031754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10920 Neighboring gene reticulocalbin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50059309-50060090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14948 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50070496-50070674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50087865-50088490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10923 Neighboring gene proline rich and Gla domain 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10924 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50095111-50095610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10925 Neighboring gene proline rich 12

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables molecular sequestering activity EXP
Inferred from Experiment
more info
PubMed 
enables molecular sequestering activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular sequestering activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nitric oxide synthase-interacting protein
Names
E3 ubiquitin-protein ligase NOSIP
RING-type E3 ubiquitin transferase NOSIP
eNOS-interacting protein
NP_001257889.1
NP_001350578.1
NP_057037.1
XP_005259021.1
XP_011525317.1
XP_011525319.1
XP_016882340.1
XP_016882341.1
XP_047294851.1
XP_047294852.1
XP_054177115.1
XP_054177116.1
XP_054177117.1
XP_054177118.1
XP_054177119.1
XP_054177120.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270960.2NP_001257889.1  nitric oxide synthase-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001257889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC009299, BE826708, DB470916
    Consensus CDS
    CCDS12772.1
    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
    Related
    ENSP00000470034.1, ENST00000596358.6
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  2. NM_001363649.3NP_001350578.1  nitric oxide synthase-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010619
    Consensus CDS
    CCDS86789.1
    UniProtKB/TrEMBL
    A0A075B6F9, A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:223287
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  3. NM_001439222.1NP_001426151.1  nitric oxide synthase-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010619
  4. NM_001439223.1NP_001426152.1  nitric oxide synthase-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010619
  5. NM_001439224.1NP_001426153.1  nitric oxide synthase-interacting protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010619
  6. NM_015953.6NP_057037.1  nitric oxide synthase-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_057037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC010619
    Consensus CDS
    CCDS12772.1
    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49555468..49580556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258964.6XP_005259021.1  nitric oxide synthase-interacting protein isoform X2

    UniProtKB/TrEMBL
    A0A075B6F9, A8K670
    Related
    ENSP00000343497.3, ENST00000339093.7
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:223287
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  2. XM_017026851.2XP_016882340.1  nitric oxide synthase-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  3. XM_047438895.1XP_047294851.1  nitric oxide synthase-interacting protein isoform X2

    UniProtKB/TrEMBL
    A0A075B6F9, A8K670
  4. XM_017026852.2XP_016882341.1  nitric oxide synthase-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:478
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cd16662
    Location:220284
    RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
  5. XM_011527017.3XP_011525319.1  nitric oxide synthase-interacting protein isoform X4

    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:579
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cl17238
    Location:151277
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  6. XM_011527015.3XP_011525317.1  nitric oxide synthase-interacting protein isoform X1

    UniProtKB/TrEMBL
    A8K670
    Conserved Domains (2) summary
    pfam15906
    Location:579
    zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
    cl17238
    Location:154280
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  7. XM_047438896.1XP_047294852.1  nitric oxide synthase-interacting protein isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52555474..52580588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321141.1XP_054177116.1  nitric oxide synthase-interacting protein isoform X2

    UniProtKB/TrEMBL
    A0A075B6F9, A8K670
  2. XM_054321142.1XP_054177117.1  nitric oxide synthase-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
  3. XM_054321144.1XP_054177119.1  nitric oxide synthase-interacting protein isoform X3

    UniProtKB/Swiss-Prot
    Q96FD2, Q9Y314
    UniProtKB/TrEMBL
    A8K670
  4. XM_054321143.1XP_054177118.1  nitric oxide synthase-interacting protein isoform X4

    UniProtKB/TrEMBL
    A8K670
  5. XM_054321140.1XP_054177115.1  nitric oxide synthase-interacting protein isoform X1

    UniProtKB/TrEMBL
    A8K670
  6. XM_054321145.1XP_054177120.1  nitric oxide synthase-interacting protein isoform X5