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SNRNP70 small nuclear ribonucleoprotein U1 subunit 70 [ Homo sapiens (human) ]

Gene ID: 6625, updated on 10-Oct-2019

Summary

Official Symbol
SNRNP70provided by HGNC
Official Full Name
small nuclear ribonucleoprotein U1 subunit 70provided by HGNC
Primary source
HGNC:HGNC:11150
See related
Ensembl:ENSG00000104852 MIM:180740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K
Expression
Ubiquitous expression in prostate (RPKM 63.5), spleen (RPKM 63.2) and 25 other tissues See more
Orthologs

Genomic context

See SNRNP70 in Genome Data Viewer
Location:
19q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49085451..49108606)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49588465..49611870)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A member 7 Neighboring gene RNA, 7SL, cytoplasmic 708, pseudogene Neighboring gene lin-7 homolog B, crumbs cell polarity complex component Neighboring gene chromosome 19 open reading frame 73 Neighboring gene PTPRF interacting protein alpha 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein 70kDa (SNRNP70), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SNRNP70 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, U1-snRNP, organism-specific biosystem (from KEGG)
    Spliceosome, U1-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
  • Spliceosome, U1-snRNP, conserved biosystem (from KEGG)
    Spliceosome, U1-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U1 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
negative regulation of chaperone-mediated autophagy TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein refolding TAS
Traceable Author Statement
more info
PubMed 
positive regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
regulation of ATPase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U1 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
U1 small nuclear ribonucleoprotein 70 kDa
Names
U1 snRNP 70 kDa
small nuclear ribonucleoprotein 70kDa (U1)
small nuclear ribonucleoprotein, U1 70kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301069.2NP_001287998.1  U1 small nuclear ribonucleoprotein 70 kDa isoform 2

    See identical proteins and their annotated locations for NP_001287998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AL560281, BC001315, DB189176, X06815
    Consensus CDS
    CCDS74417.1
    UniProtKB/Swiss-Prot
    P08621
    Related
    ENSP00000221448.5, ENST00000221448.9
    Conserved Domains (2) summary
    cd12236
    Location:102187
    RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
    pfam12220
    Location:393
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
  2. NM_003089.6NP_003080.2  U1 small nuclear ribonucleoprotein 70 kDa isoform 1

    See identical proteins and their annotated locations for NP_003080.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC001315, BM969999, DB189176, X06815
    Consensus CDS
    CCDS12756.1
    UniProtKB/Swiss-Prot
    P08621
    UniProtKB/TrEMBL
    A0A024QZD5
    Related
    ENSP00000472998.1, ENST00000598441.6
    Conserved Domains (2) summary
    cd12236
    Location:102187
    RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
    pfam12220
    Location:393
    U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49085451..49108606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527240.2XP_011525542.2  U1 small nuclear ribonucleoprotein 70 kDa isoform X1

  2. XM_011527241.2XP_011525543.1  U1 small nuclear ribonucleoprotein 70 kDa isoform X2

    See identical proteins and their annotated locations for XP_011525543.1

    UniProtKB/TrEMBL
    Q9UFS1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009820.1: Suppressed sequence

    Description
    NM_001009820.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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