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Pno1 partner of NOB1 homolog [ Mus musculus (house mouse) ]

Gene ID: 66249, updated on 18-Sep-2024

Summary

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Official Symbol
Pno1provided by MGI
Official Full Name
partner of NOB1 homologprovided by MGI
Primary source
MGI:MGI:1913499
See related
Ensembl:ENSMUSG00000020116 AllianceGenome:MGI:1913499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emi3; Imi3; 1810003N24Rik
Summary
Predicted to enable RNA binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; heart; and immune system. Orthologous to human PNO1 (partner of NOB1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 11.8), CNS E11.5 (RPKM 8.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pno1 in Genome Data Viewer
Location:
11 A2; 11 9.79 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (17153198..17161589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (17203198..17211589, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28703 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Neighboring gene STARR-seq mESC enhancer starr_28704 Neighboring gene STARR-positive B cell enhancer ABC_E3933 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:17111656-17111843 Neighboring gene dynein axonemal assembly factor 10 Neighboring gene STARR-seq mESC enhancer starr_28705 Neighboring gene C1D nuclear receptor co-repressor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pno1 tissue-specific expression and its functions related to the immune responses and proteasome activities. Wang X, et al. PLoS One, 2012. PMID 23029399, Free PMC Article
  2. Cloning and characterization of a novel human RNA binding protein gene PNO1. Zhou GJ, et al. DNA Seq, 2004 Jun. PMID 15497447
  3. Identification of novel genes expressed during metanephric induction through single-cell library screening. Abidari JM, et al. Kidney Int, 2000 Jun. PMID 10844592
  4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pno1 gene knockout is Lethal in Embryos.
    Title: Pno1 tissue-specific expression and its functions related to the immune responses and proteasome activities.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RNA-binding protein PNO1
Names
expressed during mesenchymal induction 3
induced during mesenchymal induction 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025443.2 → NP_079719.1  RNA-binding protein PNO1

    See identical proteins and their annotated locations for NP_079719.1

    Status: VALIDATED

    Source sequence(s)
    AI837771, AK007324, BY034432
    Consensus CDS
    CCDS24449.1
    UniProtKB/Swiss-Prot
    Q9CPS7
    Related
    ENSMUSP00000020317.8, ENSMUST00000020317.8
    Conserved Domains (2) summary
    smart00322
    Location:173 → 225
    KH; K homology RNA-binding domain
    COG1094
    Location:68 → 243
    Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    17153198..17161589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPS7.1 GenPept UniProtKB/Swiss-Prot:Q9CPS7

Gene LinkOut

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