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PNO1 partner of NOB1 homolog [ Homo sapiens (human) ]

Gene ID: 56902, updated on 19-Sep-2021

Summary

Official Symbol
PNO1provided by HGNC
Official Full Name
partner of NOB1 homologprovided by HGNC
Primary source
HGNC:HGNC:32790
See related
Ensembl:ENSG00000115946 MIM:618710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRP20; KHRBP1
Expression
Ubiquitous expression in thyroid (RPKM 8.8), adrenal (RPKM 8.5) and 25 other tissues See more
Orthologs
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Genomic context

See PNO1 in Genome Data Viewer
Location:
2p14
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68157888..68176238)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68385020..68403370)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 64 Neighboring gene dynein axonemal assembly factor 10 Neighboring gene VISTA enhancer hs2040 Neighboring gene protein phosphatase 3 regulatory subunit B, alpha Neighboring gene uncharacterized LOC107985892 Neighboring gene cannabinoid receptor interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
RNA-binding protein PNO1
Names
KH-type RNA-binding protein 1
RNA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329916.2NP_001316845.1  RNA-binding protein PNO1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC017083
  2. NM_001329917.2NP_001316846.1  RNA-binding protein PNO1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC017083
  3. NM_020143.4NP_064528.1  RNA-binding protein PNO1 isoform 1

    See identical proteins and their annotated locations for NP_064528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC017083, BC008304
    Consensus CDS
    CCDS1885.1
    UniProtKB/Swiss-Prot
    Q9NRX1
    Related
    ENSP00000263657.2, ENST00000263657.7
    Conserved Domains (2) summary
    cd22391
    Location:73152
    KH-I_PNO1_rpt1; first type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins
    cd22392
    Location:154249
    KH-I_PNO1_rpt2; second type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins

RNA

  1. NR_138146.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC017083

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    68157888..68176238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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