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Osgep O-sialoglycoprotein endopeptidase [ Mus musculus (house mouse) ]

Gene ID: 66246, updated on 26-Sep-2022

Summary

Official Symbol
Osgepprovided by MGI
Official Full Name
O-sialoglycoprotein endopeptidaseprovided by MGI
Primary source
MGI:MGI:1913496
See related
Ensembl:ENSMUSG00000006289 AllianceGenome:MGI:1913496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCPL-1; PRSMG1; 1500019L24Rik
Summary
Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to act upstream of or within tRNA processing. Predicted to be located in nuclear speck and plasma membrane. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytoplasm. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 3. Orthologous to human OSGEP (O-sialoglycoprotein endopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 44.1), adrenal adult (RPKM 34.5) and 28 other tissues See more
Orthologs
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Genomic context

See Osgep in Genome Data Viewer
Location:
14; 14 C1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51152831..51162350, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50915374..50924893, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene telomerase associated protein 1 Neighboring gene predicted gene, 26782 Neighboring gene kelch-like 33 Neighboring gene Apex1 promoter region Neighboring gene apurinic/apyrimidinic endonuclease 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N(6)-L-threonylcarbamoyladenine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA threonylcarbamoyladenosine modification ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of EKC/KEOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of EKC/KEOPS complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tRNA N6-adenosine threonylcarbamoyltransferase
Names
N6-L-threonylcarbamoyladenine synthase
mOsgep
probable O-sialoglycoprotein endopeptidase
probable tRNA N6-adenosine threonylcarbamoyltransferase
probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgep
t(6)A synthase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep
tRNA threonylcarbamoyladenosine biosynthesis protein Osgep
NP_598437.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133676.2NP_598437.2  tRNA N6-adenosine threonylcarbamoyltransferase

    See identical proteins and their annotated locations for NP_598437.2

    Status: VALIDATED

    Source sequence(s)
    AK142730, CA481753
    Consensus CDS
    CCDS27026.1
    UniProtKB/Swiss-Prot
    Q8BWU5
    UniProtKB/TrEMBL
    A0A0R4J1Y3, Q3UQ67
    Related
    ENSMUSP00000124039.2, ENSMUST00000159292.8
    Conserved Domains (2) summary
    PTZ00340
    Location:4335
    PTZ00340; O-sialoglycoprotein endopeptidase-like protein; Provisional
    cl22532
    Location:4108
    Carbam_trans_N; Carbamoyltransferase N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51152831..51162350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)