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Dmap1 DNA methyltransferase 1-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66233, updated on 30-Apr-2024

Summary

Official Symbol
Dmap1provided by MGI
Official Full Name
DNA methyltransferase 1-associated protein 1provided by MGI
Primary source
MGI:MGI:1913483
See related
Ensembl:ENSMUSG00000009640 AllianceGenome:MGI:1913483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DNMAP1; Dmtap1; DNMTAP1; mKIAA1425; 1500016M21Rik
Summary
Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in replication fork. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human DMAP1 (DNA methyltransferase 1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 19.7), CNS E14 (RPKM 18.3) and 28 other tissues See more
Orthologs
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Genomic context

See Dmap1 in Genome Data Viewer
Location:
4 D1; 4 53.46 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117531878..117539450, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117674681..117682321, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34669 Neighboring gene STARR-positive B cell enhancer mm9_chr4:117222596-117222897 Neighboring gene exoribonuclease 3 Neighboring gene STARR-seq mESC enhancer starr_11185 Neighboring gene STARR-seq mESC enhancer starr_11187 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:117354782-117355011 Neighboring gene predicted gene, 34746 Neighboring gene Kruppel-like transcription factor 18

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA methyltransferase 1-associated protein 1
Names
DNMT1 associated protein-1
MAT1-mediated transcriptional repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419061.1NP_001405990.1  DNA methyltransferase 1-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AL671520
    UniProtKB/Swiss-Prot
    Q99LM0, Q9CSS9, Q9DB33, Q9JI44
  2. NM_001419062.1NP_001405991.1  DNA methyltransferase 1-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AL671520
    UniProtKB/Swiss-Prot
    Q99LM0, Q9CSS9, Q9DB33, Q9JI44
  3. NM_001419063.1NP_001405992.1  DNA methyltransferase 1-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AL671520
    UniProtKB/Swiss-Prot
    Q99LM0, Q9CSS9, Q9DB33, Q9JI44
    Related
    ENSMUST00000135582.8
  4. NM_023178.3NP_075667.1  DNA methyltransferase 1-associated protein 1

    See identical proteins and their annotated locations for NP_075667.1

    Status: VALIDATED

    Source sequence(s)
    AL671520
    Consensus CDS
    CCDS18536.1
    UniProtKB/Swiss-Prot
    Q99LM0, Q9CSS9, Q9DB33, Q9JI44
    Related
    ENSMUSP00000099748.4, ENSMUST00000102687.4
    Conserved Domains (2) summary
    pfam05499
    Location:243400
    DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)
    pfam16282
    Location:124203
    SANT_DAMP1_like; SANT/Myb-like domain of DAMP1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117531878..117539450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)