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DMAP1 DNA methyltransferase 1 associated protein 1 [ Homo sapiens (human) ]

Gene ID: 55929, updated on 4-Dec-2022

Summary

Official Symbol
DMAP1provided by HGNC
Official Full Name
DNA methyltransferase 1 associated protein 1provided by HGNC
Primary source
HGNC:HGNC:18291
See related
Ensembl:ENSG00000178028 MIM:605077; AllianceGenome:HGNC:18291
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1
Summary
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 14.7), ovary (RPKM 11.2) and 25 other tissues See more
Orthologs
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Genomic context

See DMAP1 in Genome Data Viewer
Location:
1p34.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44213471..44220673)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44084361..44091563)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44679143..44686345)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904170 Neighboring gene metaxin 3 pseudogene Neighboring gene Sharpr-MPRA regulatory region 23 Neighboring gene ERI3 intronic transcript 1 Neighboring gene ERI1 exoribonuclease family member 3 Neighboring gene VISTA enhancer hs277

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11543, KIAA1425, DKFZp686L09142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA methylation TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H2A acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H2A acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone acetylation IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IC
Inferred by Curator
more info
PubMed 
involved_in regulation of apoptotic process IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of double-strand break repair IC
Inferred by Curator
more info
PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IC
Inferred by Curator
more info
PubMed 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in replication fork IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA methyltransferase 1-associated protein 1
Names
DNMT1 associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034023.2NP_001029195.1  DNA methyltransferase 1-associated protein 1

    See identical proteins and their annotated locations for NP_001029195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL137200, CA842195
    Consensus CDS
    CCDS509.1
    UniProtKB/Swiss-Prot
    Q9NPF5, Q9P2C2
    Related
    ENSP00000312697.5, ENST00000315913.9
    Conserved Domains (2) summary
    pfam05499
    Location:243402
    DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)
    pfam16282
    Location:124203
    SANT_DAMP1_like; SANT/Myb-like domain of DAMP1
  2. NM_001034024.2NP_001029196.1  DNA methyltransferase 1-associated protein 1

    See identical proteins and their annotated locations for NP_001029196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC002855, BU616029
    Consensus CDS
    CCDS509.1
    UniProtKB/Swiss-Prot
    Q9NPF5, Q9P2C2
    Related
    ENSP00000354697.6, ENST00000361745.10
    Conserved Domains (2) summary
    pfam05499
    Location:243402
    DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)
    pfam16282
    Location:124203
    SANT_DAMP1_like; SANT/Myb-like domain of DAMP1
  3. NM_019100.5NP_061973.1  DNA methyltransferase 1-associated protein 1

    See identical proteins and their annotated locations for NP_061973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC008053, BU616029, CB123593
    Consensus CDS
    CCDS509.1
    UniProtKB/Swiss-Prot
    Q9NPF5, Q9P2C2
    Related
    ENSP00000361363.2, ENST00000372289.7
    Conserved Domains (2) summary
    pfam05499
    Location:243402
    DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)
    pfam16282
    Location:124203
    SANT_DAMP1_like; SANT/Myb-like domain of DAMP1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    44213471..44220673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    44084361..44091563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)