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SNCG synuclein gamma [ Homo sapiens (human) ]

Gene ID: 6623, updated on 23-Nov-2021

Summary

Official Symbol
SNCGprovided by HGNC
Official Full Name
synuclein gammaprovided by HGNC
Primary source
HGNC:HGNC:11141
See related
Ensembl:ENSG00000173267 MIM:602998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR; BCSG1
Summary
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]
Expression
Biased expression in fat (RPKM 120.9), urinary bladder (RPKM 74.6) and 8 other tissues See more
Orthologs
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Genomic context

See SNCG in Genome Data Viewer
Location:
10q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (86955759..86963260)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88715516..88723015)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4131 Neighboring gene multimerin 2 Neighboring gene Sharpr-MPRA regulatory region 565 Neighboring gene ADIRF antisense RNA 1 Neighboring gene adipogenesis regulatory factor Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 11 Neighboring gene BMS1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cuprous ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gamma-synuclein
Names
-synuclein
E pound-synuclein
breast cancer-specific gene 1 protein
persyn
synoretin
synuclein, gamma (breast cancer-specific protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008783.1 RefSeqGene

    Range
    5069..9728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330120.2NP_001317049.1  gamma-synuclein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC025268, BC014098, BG708703, EB388950
    Consensus CDS
    CCDS81483.1
    UniProtKB/Swiss-Prot
    O76070
    UniProtKB/TrEMBL
    F8W754
    Related
    ENSP00000344658.4, ENST00000348795.8
    Conserved Domains (1) summary
    pfam01387
    Location:154
    Synuclein; Synuclein
  2. NM_003087.3NP_003078.2  gamma-synuclein isoform 1

    See identical proteins and their annotated locations for NP_003078.2

    Status: REVIEWED

    Source sequence(s)
    AK223367, BC014098
    Consensus CDS
    CCDS7380.1
    UniProtKB/Swiss-Prot
    O76070
    UniProtKB/TrEMBL
    Q6FHG5
    Related
    ENSP00000361087.3, ENST00000372017.4
    Conserved Domains (1) summary
    pfam01387
    Location:1110
    Synuclein; Synuclein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    86955759..86963260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448137.1XP_024303905.1  gamma-synuclein isoform X1

    Conserved Domains (1) summary
    pfam01387
    Location:154
    Synuclein
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