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Sncg synuclein, gamma [ Mus musculus (house mouse) ]

Gene ID: 20618, updated on 8-Feb-2024

Summary

Official Symbol
Sncgprovided by MGI
Official Full Name
synuclein, gammaprovided by MGI
Primary source
MGI:MGI:1298397
See related
Ensembl:ENSMUSG00000023064 AllianceGenome:MGI:1298397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
persyn
Summary
Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and cuprous ion binding activity. Involved in protein secretion. Acts upstream of or within several processes, including adult locomotory behavior; chemical synaptic transmission; and regulation of secretion by cell. Located in axon; cytoplasm; and neuronal cell body. Is expressed in adipose tissue; central nervous system; intestine; peripheral nervous system; and retina. Used to study amyotrophic lateral sclerosis type 1. Human ortholog(s) of this gene implicated in Lewy body dementia. Orthologous to human SNCG (synuclein gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 361.5), genital fat pad adult (RPKM 239.2) and 5 other tissues See more
Orthologs
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Genomic context

See Sncg in Genome Data Viewer
Location:
14 B; 14 20.81 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34092231..34096626, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34370274..34374669, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36378 Neighboring gene predicted gene, 53843 Neighboring gene predicted gene, 41131 Neighboring gene STARR-seq mESC enhancer starr_36379 Neighboring gene multimerin 2 Neighboring gene STARR-seq mESC enhancer starr_36380 Neighboring gene bone morphogenetic protein receptor, type 1A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables cuprous ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular response to stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of dopamine secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011430.3NP_035560.1  gamma-synuclein

    See identical proteins and their annotated locations for NP_035560.1

    Status: VALIDATED

    Source sequence(s)
    AA690669, BC028508
    Consensus CDS
    CCDS26937.1
    UniProtKB/Swiss-Prot
    Q9Z0F7
    UniProtKB/TrEMBL
    Q5GQ64
    Related
    ENSMUSP00000023826.5, ENSMUST00000023826.5
    Conserved Domains (1) summary
    pfam01387
    Location:1105
    Synuclein; Synuclein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    34092231..34096626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)