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Llph LLP homolog, long-term synaptic facilitation (Aplysia) [ Mus musculus (house mouse) ]

Gene ID: 66225, updated on 5-Mar-2024

Summary

Official Symbol
Llphprovided by MGI
Official Full Name
LLP homolog, long-term synaptic facilitation (Aplysia)provided by MGI
Primary source
MGI:MGI:1913475
See related
Ensembl:ENSMUSG00000020224 AllianceGenome:MGI:1913475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190005P17Rik
Summary
Enables basal RNA polymerase II transcription machinery binding activity. Involved in dendrite extension and positive regulation of dendritic spine development. Located in nucleolus. Orthologous to human LLPH (LLP homolog, long-term synaptic facilitation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 29.1), CNS E11.5 (RPKM 23.5) and 21 other tissues See more
Orthologs
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Genomic context

See Llph in Genome Data Viewer
Location:
10 D2; 10 67.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (120062967..120067976)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120227048..120232071)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E8371 Neighboring gene STARR-positive B cell enhancer ABC_E8372 Neighboring gene predicted gene, 38500 Neighboring gene STARR-positive B cell enhancer ABC_E5193 Neighboring gene STARR-positive B cell enhancer ABC_E8373 Neighboring gene STARR-seq mESC enhancer starr_28059 Neighboring gene transmembrane BAX inhibitor motif containing 4 Neighboring gene predicted gene, 40782 Neighboring gene STARR-positive B cell enhancer ABC_E3923 Neighboring gene STARR-seq mESC enhancer starr_28060 Neighboring gene STARR-seq mESC enhancer starr_28061 Neighboring gene RIKEN cDNA 1700006J14 gene Neighboring gene RIKEN cDNA 9230105E05 gene Neighboring gene predicted gene, 40783 Neighboring gene high mobility group AT-hook 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Clone Names

  • MGC117871

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables basal RNA polymerase II transcription machinery binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables basal RNA polymerase II transcription machinery binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in dendrite extension IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dendrite extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417829.1NP_001404758.1  protein LLP homolog

    Status: VALIDATED

    Source sequence(s)
    AC144942
    UniProtKB/Swiss-Prot
    Q3KQP9, Q9D945
    Related
    ENSMUSP00000118254.3, ENSMUST00000130198.3
  2. NM_025431.3NP_079707.1  protein LLP homolog

    See identical proteins and their annotated locations for NP_079707.1

    Status: VALIDATED

    Source sequence(s)
    AC144942
    Consensus CDS
    CCDS24206.1
    UniProtKB/Swiss-Prot
    Q3KQP9, Q9D945
    Related
    ENSMUSP00000020444.9, ENSMUST00000020444.16
    Conserved Domains (1) summary
    pfam10169
    Location:3121
    Laps; Learning-associated protein

RNA

  1. NR_184636.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC144942

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    120062967..120067976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)