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Med7 mediator complex subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 66213, updated on 2-Nov-2024

Summary

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Official Symbol
Med7provided by MGI
Official Full Name
mediator complex subunit 7provided by MGI
Primary source
MGI:MGI:1913463
See related
Ensembl:ENSMUSG00000020397 AllianceGenome:MGI:1913463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crsp9; Crsp33; 1110063B05Rik
Summary
Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within somatic stem cell population maintenance. Part of mediator complex. Is expressed in cerebral cortex; genitourinary system; and tibialis anterior. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.7), placenta adult (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Med7 in Genome Data Viewer
Location:
11 B1.1; 11 27.88 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46327742..46333548)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46436936..46442721)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46157730-46157921 Neighboring gene IL2 inducible T cell kinase Neighboring gene predicted gene 12167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46202936-46203219 Neighboring gene STARR-positive B cell enhancer ABC_E3943 Neighboring gene STARR-seq mESC enhancer starr_29325 Neighboring gene golgi associated RAB2 interactor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46234578-46234761 Neighboring gene STARR-seq mESC enhancer starr_29326 Neighboring gene STARR-positive B cell enhancer ABC_E1415 Neighboring gene predicted gene 12168 Neighboring gene hepatitis A virus cellular receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Jiang YW, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671713, Free PMC Article
  2. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Sasaki N, et al. Genomics, 1998 Apr 15. PMID 9598303
  3. Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Chen J, et al. Genes Dev, 2011 Apr 1. PMID 21460039, Free PMC Article
  4. Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Kolonay DW, et al. Front Cell Dev Biol, 2024. PMID 38690566, Free PMC Article
  5. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 7
Names
CRSP complex subunit 9
cofactor required for Sp1 transcriptional activation subunit 9
cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104530.1 → NP_001098000.1  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_001098000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK010357, AL669948
    Consensus CDS
    CCDS36134.1
    UniProtKB/Swiss-Prot
    Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
    Related
    ENSMUSP00000020665.7, ENSMUST00000020665.13
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  2. NM_001104556.1 → NP_001098026.1  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_001098026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK010357, AK144918, AK147739, AK210054, AL669948, BE333513, C88719, CJ145922
    Consensus CDS
    CCDS36134.1
    UniProtKB/Swiss-Prot
    Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
    Related
    ENSMUSP00000131852.2, ENSMUST00000170928.8
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  3. NM_001104557.1 → NP_001098027.1  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_001098027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK010357, AK144918, AK147739, AK210054, AL669948, BY135693, CF983034, CK030901, CK788351
    Consensus CDS
    CCDS36134.1
    UniProtKB/Swiss-Prot
    Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  4. NM_025426.3 → NP_079702.3  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_079702.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK010357, AK147739, AL669948, CJ145922
    Consensus CDS
    CCDS36134.1
    UniProtKB/Swiss-Prot
    Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
    Related
    ENSMUSP00000104855.4, ENSMUST00000109232.4
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    46327742..46333548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533931.5 → XP_006533994.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006533994.1

    UniProtKB/Swiss-Prot
    Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  2. XM_006533932.5 → XP_006533995.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006533995.1

    UniProtKB/Swiss-Prot
    Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  3. XM_006533933.5 → XP_006533996.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006533996.1

    UniProtKB/Swiss-Prot
    Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein

  4. XM_006533934.5 → XP_006533997.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006533997.1

    UniProtKB/Swiss-Prot
    Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
    Conserved Domains (1) summary
    pfam05983
    Location:7 → 164
    Med7; MED7 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZB6.2 GenPept UniProtKB/Swiss-Prot:Q9CZB6

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