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MED7 mediator complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 9443, updated on 7-Jun-2020

Summary

Official Symbol
MED7provided by HGNC
Official Full Name
mediator complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:2378
See related
Ensembl:ENSG00000155868 MIM:605045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC34; CRSP9; CRSP33
Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 12.0), thyroid (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See MED7 in Genome Data Viewer
Location:
5q33.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (157137424..157142865, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156565451..156569921, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene hepatitis A virus cellular receptor 1 Neighboring gene hepatitis A virus cellular receptor 2 Neighboring gene family with sequence similarity 71 member B Neighboring gene IL2 inducible T cell kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 7 (MED7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of mediator complex subunit 7 (MED7; CRSP9) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of mediator complex subunit 7 (MED7) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED7 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: HAVCR2

Homology

Clone Names

  • MGC12284

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 7
Names
CRSP complex subunit 9
RNA polymerase transcriptional regulation mediator subunit 7 homolog
activator-recruited cofactor 34 kDa component
cofactor required for Sp1 transcriptional activation subunit 9
cofactor required for Sp1 transcriptional activation, subunit 9 (33kD)
cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa
transcriptional coactivator CRSP33

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100816.1NP_001094286.1  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_001094286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AF104251, BQ011916, BQ130907
    Consensus CDS
    CCDS4334.1
    UniProtKB/Swiss-Prot
    O43513
    UniProtKB/TrEMBL
    Q6IAZ5
    Related
    ENSP00000401046.1, ENST00000420343.1
    Conserved Domains (1) summary
    pfam05983
    Location:7164
    Med7; MED7 protein
  2. NM_004270.5NP_004261.1  mediator of RNA polymerase II transcription subunit 7

    See identical proteins and their annotated locations for NP_004261.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC010609, AF031383, AV711090, BQ011916
    Consensus CDS
    CCDS4334.1
    UniProtKB/Swiss-Prot
    O43513
    UniProtKB/TrEMBL
    Q6IAZ5
    Related
    ENSP00000286317.5, ENST00000286317.6
    Conserved Domains (1) summary
    pfam05983
    Location:7164
    Med7; MED7 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    157137424..157142865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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