Nenf neuron derived neurotrophic factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nenfprovided by MGI
Official Full Name: neuron derived neurotrophic factorprovided by MGI
Primary source: MGI:MGI:1913458
See related: Ensembl:ENSMUSG00000037499 AllianceGenome:MGI:1913458
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spuf; SCIRP10; 1110060M21Rik
Summary: Enables growth factor activity. Involved in negative regulation of appetite. Acts upstream of or within positive regulation of MAPK cascade. Located in endoplasmic reticulum; extracellular space; and mitochondrion. Is expressed in brain; heart; lung; metanephros; and spinal cord. Orthologous to human NENF (neudesin neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 144.0), adrenal adult (RPKM 120.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 96.28 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (191038984..191050328, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (191306787..191318131, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling.
Title: A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling.
Testicular Hypoplasia with Normal Fertility in Neudesin-Knockout Mice.
Title: Testicular Hypoplasia with Normal Fertility in Neudesin-Knockout Mice.
neudesin, which may be a negative regulator of sympathetic activity, could represent a novel regulator of the development of obesity and obesity-related metabolic dysfunctions.
Title: Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity.
Neuron-derived neurotrophic factor (NENF) is an important central modulator of food intake.
Title: Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite.
These findings suggest that neudesin plays a critical role in the early stage of adipocyte differentiation in which C/EBPbeta induces PPARgamma and C/EBPalpha expressions, by controlling the MAPK pathway.
Title: Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade.
Neudesin is the first extracellular heme-binding protein that shows signal transducing activity by itself. The present findings may shed new light on the function of extracellular heme-binding proteins
Title: Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain.
identification of neudesin, a novel mouse secreted protein showing neurotrophic activity in primary cultured mouse neurons
Title: Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity.
The present findings have revealed new potential roles of neudesin in neural cell proliferation and neuronal differentiation.
Title: Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

Nenf (e-PCR), detects polymorphism
- UniSTS:497297

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neudesin

Names: SCIRP10-related protein; Spinal cord injury related protein 10; secreted protein of unknown function

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.