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Nenf neuron derived neurotrophic factor [ Mus musculus (house mouse) ]

Gene ID: 66208, updated on 9-May-2024

Summary

Official Symbol
Nenfprovided by MGI
Official Full Name
neuron derived neurotrophic factorprovided by MGI
Primary source
MGI:MGI:1913458
See related
Ensembl:ENSMUSG00000037499 AllianceGenome:MGI:1913458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spuf; SCIRP10; 1110060M21Rik
Summary
Enables growth factor activity. Involved in negative regulation of appetite. Acts upstream of or within positive regulation of MAPK cascade. Located in endoplasmic reticulum; extracellular space; and mitochondrion. Is expressed in brain; heart; lung; metanephros; and spinal cord. Orthologous to human NENF (neudesin neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 144.0), adrenal adult (RPKM 120.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
1 H6; 1 96.28 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191038984..191050328, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191306787..191318131, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4405 Neighboring gene STARR-seq mESC enhancer starr_03429 Neighboring gene STARR-positive B cell enhancer ABC_E2027 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:193017813-193017996 Neighboring gene activating transcription factor 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:193021775-193022076 Neighboring gene RIKEN cDNA D730003I15 gene Neighboring gene STARR-positive B cell enhancer ABC_E1578 Neighboring gene STARR-positive B cell enhancer ABC_E4407 Neighboring gene STARR-positive B cell enhancer ABC_E7786 Neighboring gene STARR-positive B cell enhancer mm9_chr1:193099421-193099721 Neighboring gene STARR-positive B cell enhancer ABC_E3354 Neighboring gene STARR-positive B cell enhancer ABC_E11113 Neighboring gene STARR-positive B cell enhancer ABC_E7787 Neighboring gene proton activated chloride channel 1 Neighboring gene protein phosphatase 2, regulatory subunit B', alpha Neighboring gene RAB11B, member RAS oncogene family, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neudesin
Names
SCIRP10-related protein
Spinal cord injury related protein 10
secreted protein of unknown function

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025424.3NP_079700.1  neudesin precursor

    See identical proteins and their annotated locations for NP_079700.1

    Status: VALIDATED

    Source sequence(s)
    AC115896, AK002413
    Consensus CDS
    CCDS15618.1
    UniProtKB/Swiss-Prot
    Q5TM91, Q9CQ45
    Related
    ENSMUSP00000046311.10, ENSMUST00000046770.10
    Conserved Domains (1) summary
    pfam00173
    Location:45100
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191038984..191050328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)