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NENF neudesin neurotrophic factor [ Homo sapiens (human) ]

Gene ID: 29937, updated on 1-Jun-2020

Summary

Official Symbol
NENFprovided by HGNC
Official Full Name
neudesin neurotrophic factorprovided by HGNC
Primary source
HGNC:HGNC:30384
See related
Ensembl:ENSG00000117691 MIM:611874
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIR2; SPUF; SCIRP10
Summary
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in ovary (RPKM 25.5), prostate (RPKM 23.2) and 25 other tissues See more
Orthologs

Genomic context

See NENF in Genome Data Viewer
Location:
1q32.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (212432920..212446379)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (212606229..212619721)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene proton activated chloride channel 1 Neighboring gene uncharacterized LOC105372906 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11595 Neighboring gene long intergenic non-protein coding RNA 2771 Neighboring gene uncharacterized LOC105372908

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
neudesin
Names
SCIRP10-related protein
Spinal cord injury related protein 10
cell growth-inhibiting protein 47
cell immortalization-related protein 2
neuron-derived neurotrophic factor
secreted protein of unknown function

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013349.5NP_037481.1  neudesin precursor

    See identical proteins and their annotated locations for NP_037481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AF173937, BC008823, DB574171
    Consensus CDS
    CCDS1505.1
    UniProtKB/Swiss-Prot
    Q9UMX5
    Related
    ENSP00000355955.3, ENST00000366988.5
    Conserved Domains (1) summary
    pfam00173
    Location:48109
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RNA

  1. NR_026598.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC008823, DB502983, DB574171
    Related
    ENST00000479589.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    212432920..212446379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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