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Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 [ Mus musculus (house mouse) ]

Gene ID: 66148, updated on 27-Feb-2024

Summary

Official Symbol
Dnajc15provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C15provided by MGI
Primary source
MGI:MGI:1913398
See related
Ensembl:ENSMUSG00000022013 AllianceGenome:MGI:1913398
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCJ; Dnajd1; 1110003P16Rik
Summary
Predicted to enable ATPase activator activity. Acts upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Located in mitochondrial inner membrane. Is expressed in endocrine gland; genitourinary system; heart; and nervous system. Orthologous to human DNAJC15 (DnaJ heat shock protein family (Hsp40) member C15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 177.3), ovary adult (RPKM 65.1) and 27 other tissues See more
Orthologs
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Genomic context

See Dnajc15 in Genome Data Viewer
Location:
14 D3; 14 41.04 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (78063657..78112357, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77826217..77874917, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37215 Neighboring gene predicted gene, 30467 Neighboring gene predicted gene 1587 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:78261113-78261296 Neighboring gene epithelial stromal interaction 1 Neighboring gene STARR-seq mESC enhancer starr_37217 Neighboring gene family with sequence similarity 216, member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of PAM complex, Tim23 associated import motor IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily C member 15
Names
DnaJ (Hsp40) homolog, subfamily C, member 15
DnaJ (Hsp40) homolog, subfamily D, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025384.3NP_079660.1  dnaJ homolog subfamily C member 15

    See identical proteins and their annotated locations for NP_079660.1

    Status: PROVISIONAL

    Source sequence(s)
    BC027509
    Consensus CDS
    CCDS27292.1
    UniProtKB/Swiss-Prot
    Q78YY6
    Related
    ENSMUSP00000154390.2, ENSMUST00000226459.2
    Conserved Domains (1) summary
    cl02542
    Location:85142
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    78063657..78112357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)