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DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 [ Homo sapiens (human) ]

Gene ID: 29103, updated on 22-Sep-2022

Summary

Official Symbol
DNAJC15provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C15provided by HGNC
Primary source
HGNC:HGNC:20325
See related
Ensembl:ENSG00000120675 MIM:615339; AllianceGenome:HGNC:20325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCJ; HSD18; DNAJD1
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 13.6), small intestine (RPKM 12.6) and 24 other tissues See more
Orthologs
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Genomic context

See DNAJC15 in Genome Data Viewer
Location:
13q14.11
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (43023586..43114213)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (42242004..42332653)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (43597722..43688349)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene epithelial stromal interaction 1 Neighboring gene uncharacterized LOC105370178 Neighboring gene uncharacterized LOC105370179 Neighboring gene long intergenic non-protein coding RNA 400 Neighboring gene LINC00400 intron CAGE-defined mid-level expression enhancer Neighboring gene molybdenum cofactor synthesis 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
dnaJ homolog subfamily C member 15
Names
DNAJ domain-containing
DnaJ (Hsp40) homolog, subfamily C, member 15
DnaJ (Hsp40) homolog, subfamily D, member 1
cell growth-inhibiting gene 22 protein
methylation-controlled J protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013238.3NP_037370.2  dnaJ homolog subfamily C member 15

    See identical proteins and their annotated locations for NP_037370.2

    Status: VALIDATED

    Source sequence(s)
    AF126743, AL445217, CA444534
    Consensus CDS
    CCDS9388.1
    UniProtKB/Swiss-Prot
    Q6X963, Q9Y5T4
    Related
    ENSP00000368523.2, ENST00000379221.4
    Conserved Domains (1) summary
    cl02542
    Location:41144
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    43023586..43114213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    42242004..42332653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)