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POLR3D RNA polymerase III subunit D [ Homo sapiens (human) ]

Gene ID: 661, updated on 1-Jun-2020

Summary

Official Symbol
POLR3Dprovided by HGNC
Official Full Name
RNA polymerase III subunit Dprovided by HGNC
Primary source
HGNC:HGNC:1080
See related
Ensembl:ENSG00000168495 MIM:187280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C53; RPC4; BN51T; RPC53; TSBN51
Summary
This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 12.6), placenta (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See POLR3D in Genome Data Viewer
Location:
8p21.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22245104..22254601)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22102619..22108680)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein Neighboring gene uncharacterized LOC100507071 Neighboring gene microRNA 320a Neighboring gene piwi like RNA-mediated gene silencing 2 Neighboring gene solute carrier family 39 member 14 Neighboring gene ribosomal protein L21 pseudogene 77

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC4
Names
BN51 (BHK21) temperature sensitivity complementing
DNA-directed RNA polymerase III 47 kDa polypeptide
DNA-directed RNA polymerase III subunit D
RNA polymerase III 47 kDa subunit
RNA polymerase III subunit C4
RPC53 homolog
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
polymerase (RNA) III subunit D
temperature sensitive complementation, cell cycle specific, tsBN51
NP_001713.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001722.3NP_001713.2  DNA-directed RNA polymerase III subunit RPC4

    See identical proteins and their annotated locations for NP_001713.2

    Status: REVIEWED

    Source sequence(s)
    AC105206, AK026588, AY092086, BQ006609
    Consensus CDS
    CCDS34858.1
    UniProtKB/Swiss-Prot
    P05423
    Related
    ENSP00000303088.4, ENST00000306433.9
    Conserved Domains (1) summary
    pfam05132
    Location:321387
    RNA_pol_Rpc4; RNA polymerase III RPC4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22245104..22254601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_949463.2 RNA Sequence

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