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Hsd17b14 hydroxysteroid (17-beta) dehydrogenase 14 [ Mus musculus (house mouse) ]

Gene ID: 66065, updated on 26-Sep-2022

Summary

Official Symbol
Hsd17b14provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 14provided by MGI
Primary source
MGI:MGI:1913315
See related
Ensembl:ENSMUSG00000030825 AllianceGenome:MGI:1913315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dhrs10; retSDR3; 0610039E24Rik
Summary
Predicted to enable estradiol 17-beta-dehydrogenase activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Predicted to be involved in steroid catabolic process. Predicted to be active in cytosol. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 10.3), bladder adult (RPKM 5.5) and 6 other tissues See more
Orthologs
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Genomic context

See Hsd17b14 in Genome Data Viewer
Location:
7; 7 B3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45204345..45216745)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45554920..45567321)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tubby-like protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387 Neighboring gene RIKEN cDNA 0610005C13 gene Neighboring gene branched chain aminotransferase 2, mitochondrial Neighboring gene predicted gene, 31479

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables estradiol 17-beta-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables estradiol 17-beta-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in steroid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
17-beta-hydroxysteroid dehydrogenase 14
Names
dehydrogenase/reductase (SDR family) member 10
NP_079606.3
XP_006541132.2
XP_006541133.1
XP_011249191.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025330.3NP_079606.3  17-beta-hydroxysteroid dehydrogenase 14

    Status: VALIDATED

    Source sequence(s)
    AC151602
    Consensus CDS
    CCDS21251.2
    UniProtKB/TrEMBL
    E9Q3D4
    Related
    ENSMUSP00000103381.4, ENSMUST00000107752.12
    Conserved Domains (2) summary
    PRK05653
    Location:8251
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    cl21454
    Location:1256
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45204345..45216745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541070.5XP_006541133.1  17-beta-hydroxysteroid dehydrogenase 14 isoform X2

    Related
    ENSMUSP00000147715.2, ENSMUST00000210300.2
    Conserved Domains (1) summary
    cl21454
    Location:1158
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_011250889.3XP_011249191.1  17-beta-hydroxysteroid dehydrogenase 14 isoform X3

    Conserved Domains (1) summary
    cl21454
    Location:21154
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_006541069.2XP_006541132.2  17-beta-hydroxysteroid dehydrogenase 14 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:46179
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins