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HSD17B14 hydroxysteroid 17-beta dehydrogenase 14 [ Homo sapiens (human) ]

Gene ID: 51171, updated on 18-Aug-2020

Summary

Official Symbol
HSD17B14provided by HGNC
Official Full Name
hydroxysteroid 17-beta dehydrogenase 14provided by HGNC
Primary source
HGNC:HGNC:23238
See related
Ensembl:ENSG00000087076 MIM:612832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHRS10; SDR47C1; retSDR3
Summary
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
Expression
Broad expression in kidney (RPKM 32.8), ovary (RPKM 12.9) and 14 other tissues See more
Orthologs

Genomic context

See HSD17B14 in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48813014..48836688, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49316274..49339935, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 317, pseudogene Neighboring gene branched chain amino acid transaminase 2 Neighboring gene uncharacterized LOC105372432 Neighboring gene pleckstrin homology domain containing A4 Neighboring gene protein phosphatase 1 regulatory subunit 15A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
estradiol 17-beta-dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
testosterone 17-beta-dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
estrogen biosynthetic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
steroid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
17-beta-hydroxysteroid dehydrogenase 14
Names
17-beta-HSD 14
17-beta-hydroxysteroid dehydrogenase DHRS10
dehydrogenase/reductase (SDR family) member 10
retinal short-chain dehydrogenase/reductase 3
retinal short-chain dehydrogenase/reductase retSDR3
short chain dehydrogenase/reductase family 47C member 1
testicular tissue protein Li 52

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016246.3NP_057330.2  17-beta-hydroxysteroid dehydrogenase 14

    See identical proteins and their annotated locations for NP_057330.2

    Status: VALIDATED

    Source sequence(s)
    BC006283, BC006294, BI602824
    Consensus CDS
    CCDS12736.1
    UniProtKB/Swiss-Prot
    Q9BPX1
    UniProtKB/TrEMBL
    A0A140VJH8
    Related
    ENSP00000263278.3, ENST00000263278.9
    Conserved Domains (1) summary
    cd08933
    Location:1256
    RDH_SDR_c; retinal dehydrogenase-like, classical (c) SDR

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48813014..48836688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258969.4XP_005259026.1  17-beta-hydroxysteroid dehydrogenase 14 isoform X1

    Related
    ENSP00000469557.1, ENST00000595764.1
    Conserved Domains (1) summary
    cl21454
    Location:1181
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_005258970.3XP_005259027.1  17-beta-hydroxysteroid dehydrogenase 14 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:1102
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_243938.3 RNA Sequence

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