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HSD17B14 hydroxysteroid 17-beta dehydrogenase 14 [ Homo sapiens (human) ]

Gene ID: 51171, updated on 5-Aug-2022

Summary

Official Symbol
HSD17B14provided by HGNC
Official Full Name
hydroxysteroid 17-beta dehydrogenase 14provided by HGNC
Primary source
HGNC:HGNC:23238
See related
Ensembl:ENSG00000087076 MIM:612832; AllianceGenome:HGNC:23238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHRS10; SDR47C1; retSDR3
Summary
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
Expression
Broad expression in kidney (RPKM 32.8), ovary (RPKM 12.9) and 14 other tissues See more
Orthologs
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Genomic context

See HSD17B14 in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48813018..48836491, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51808041..51831370, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49316275..49339748, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene branched chain amino acid transaminase 2 Neighboring gene Sharpr-MPRA regulatory region 11839 Neighboring gene CRISPRi-FlowFISH-validated BCAT2 regulatory element Neighboring gene CRISPRi-FlowFISH-validated FTL regulatory element Neighboring gene pleckstrin homology domain containing A4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49375236-49375847 Neighboring gene protein phosphatase 1 regulatory subunit 15A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
enables estradiol 17-beta-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables estradiol 17-beta-dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in steroid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
17-beta-hydroxysteroid dehydrogenase 14
Names
17-beta-HSD 14
17-beta-hydroxysteroid dehydrogenase DHRS10
dehydrogenase/reductase (SDR family) member 10
retinal short-chain dehydrogenase/reductase 3
retinal short-chain dehydrogenase/reductase retSDR3
short chain dehydrogenase/reductase family 47C member 1
testicular tissue protein Li 52
NP_057330.2
XP_005259026.1
XP_047294853.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016246.3NP_057330.2  17-beta-hydroxysteroid dehydrogenase 14

    See identical proteins and their annotated locations for NP_057330.2

    Status: VALIDATED

    Source sequence(s)
    BC006283, BC006294, BI602824
    Consensus CDS
    CCDS12736.1
    UniProtKB/Swiss-Prot
    Q9BPX1, Q9UKU3
    UniProtKB/TrEMBL
    A0A140VJH8
    Related
    ENSP00000263278.3, ENST00000263278.9
    Conserved Domains (1) summary
    cd08933
    Location:1256
    RDH_SDR_c; retinal dehydrogenase-like, classical (c) SDR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48813018..48836491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258969.5XP_005259026.1  17-beta-hydroxysteroid dehydrogenase 14 isoform X1

    Related
    ENSP00000469557.1, ENST00000595764.1
    Conserved Domains (1) summary
    cl21454
    Location:1181
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_047438897.1XP_047294853.1  17-beta-hydroxysteroid dehydrogenase 14 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51808041..51831370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)