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Tmem176a transmembrane protein 176A [ Mus musculus (house mouse) ]

Gene ID: 66058, updated on 8-Dec-2022

Summary

Official Symbol
Tmem176aprovided by MGI
Official Full Name
transmembrane protein 176Aprovided by MGI
Primary source
MGI:MGI:1913308
See related
Ensembl:ENSMUSG00000023367 AllianceGenome:MGI:1913308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Keg2; 0610011I04Rik
Summary
Acts upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; ganglia; metanephros; node; and notochord. Orthologous to human TMEM176A (transmembrane protein 176A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 212.4), adrenal adult (RPKM 143.6) and 19 other tissues See more
Orthologs
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Genomic context

See Tmem176a in Genome Data Viewer
Location:
6; 6 B2.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48818417..48822298)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48841483..48845364)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene septin 7 pseudogene Neighboring gene transmembrane protein 176B Neighboring gene predicted gene 44764 Neighboring gene predicted gene 7932 Neighboring gene amine oxidase, copper-containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 176A
Names
gene signature 188
kidney expressed gene 2
kidney-expressed gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098271.1NP_001091741.1  transmembrane protein 176A

    See identical proteins and their annotated locations for NP_001091741.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK002546, BY352519
    Consensus CDS
    CCDS39482.1
    UniProtKB/Swiss-Prot
    Q8K4T0, Q9DCS1
    Related
    ENSMUSP00000131775.2, ENSMUST00000168406.4
    Conserved Domains (1) summary
    pfam04103
    Location:63223
    CD20; CD20-like family
  2. NM_025326.4NP_079602.4  transmembrane protein 176A

    See identical proteins and their annotated locations for NP_079602.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK002546, BY018646
    Consensus CDS
    CCDS39482.1
    UniProtKB/Swiss-Prot
    Q8K4T0, Q9DCS1
    Related
    ENSMUSP00000098969.5, ENSMUST00000101426.11
    Conserved Domains (1) summary
    pfam04103
    Location:63223
    CD20; CD20-like family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48818417..48822298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)