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TMEM176A transmembrane protein 176A [ Homo sapiens (human) ]

Gene ID: 55365, updated on 9-Jun-2025
Official Symbol
TMEM176Aprovided by HGNC
Official Full Name
transmembrane protein 176Aprovided by HGNC
Primary source
HGNC:HGNC:24930
See related
Ensembl:ENSG00000002933 MIM:610334; AllianceGenome:HGNC:24930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GS188; MS4B1; HCA112
Summary
Predicted to act upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in liver (RPKM 172.7), kidney (RPKM 114.0) and 15 other tissues See more
Orthologs
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See TMEM176A in Genome Data Viewer
Location:
7q36.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150800769..150805118)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151973144..151977889)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150497857..150502206)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18783 Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1 Neighboring gene uncharacterized LOC105375566 Neighboring gene transmembrane protein 176B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150496449-150497148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150497149-150497848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150497849-150498548 Neighboring gene uncharacterized LOC105375567 Neighboring gene uncharacterized LOC124901775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150549187-150549758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150553923-150554766 Neighboring gene amine oxidase copper containing 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transmembrane protein 176A
Names
hepatocellular carcinoma-associated antigen 112
likley ortholog of mouse GS188

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018487.3NP_060957.2  transmembrane protein 176A

    See identical proteins and their annotated locations for NP_060957.2

    Status: VALIDATED

    Source sequence(s)
    BC008303
    Consensus CDS
    CCDS5909.1
    UniProtKB/Swiss-Prot
    D3DX00, Q96HP8, Q9NYC7
    UniProtKB/TrEMBL
    A0A090N8H6
    Related
    ENSP00000004103.3, ENST00000004103.8
    Conserved Domains (1) summary
    pfam04103
    Location:56194
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150800769..150805118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516376.4XP_011514678.1  transmembrane protein 176A isoform X3

    Conserved Domains (1) summary
    pfam04103
    Location:73211
    CD20; CD20-like family
  2. XM_011516378.3XP_011514680.1  transmembrane protein 176A isoform X1

    Conserved Domains (1) summary
    pfam04103
    Location:73203
    CD20; CD20-like family
  3. XM_024446824.2XP_024302592.1  transmembrane protein 176A isoform X2

    Conserved Domains (1) summary
    pfam04103
    Location:56186
    CD20; CD20-like family
  4. XM_047420570.1XP_047276526.1  transmembrane protein 176A isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151973144..151977889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358578.1XP_054214553.1  transmembrane protein 176A isoform X5

  2. XM_054358579.1XP_054214554.1  transmembrane protein 176A isoform X1

  3. XM_054358580.1XP_054214555.1  transmembrane protein 176A isoform X2