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TMEM176A transmembrane protein 176A [ Homo sapiens (human) ]

Gene ID: 55365, updated on 1-Aug-2020

Summary

Official Symbol
TMEM176Aprovided by HGNC
Official Full Name
transmembrane protein 176Aprovided by HGNC
Primary source
HGNC:HGNC:24930
See related
Ensembl:ENSG00000002933 MIM:610334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GS188; MS4B1; HCA112
Expression
Broad expression in liver (RPKM 172.7), kidney (RPKM 114.0) and 15 other tissues See more
Orthologs

Genomic context

See TMEM176A in Genome Data Viewer
Location:
7q36.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (150800543..150805119)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150497854..150502208)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375566 Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1 Neighboring gene transmembrane protein 176B Neighboring gene uncharacterized LOC105375567 Neighboring gene amine oxidase copper containing 1 Neighboring gene VISTA enhancer hs2192 Neighboring gene potassium voltage-gated channel subfamily H member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 176A
Names
hepatocellular carcinoma-associated antigen 112
likley ortholog of mouse GS188

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018487.3NP_060957.2  transmembrane protein 176A

    See identical proteins and their annotated locations for NP_060957.2

    Status: VALIDATED

    Source sequence(s)
    BC008303
    Consensus CDS
    CCDS5909.1
    UniProtKB/Swiss-Prot
    Q96HP8
    UniProtKB/TrEMBL
    A0A090N8H6
    Related
    ENSP00000004103.3, ENST00000004103.8
    Conserved Domains (1) summary
    pfam04103
    Location:56194
    CD20; CD20-like family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    150800543..150805119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012393.1XP_016867882.1  transmembrane protein 176A isoform X3

  2. XM_024446824.1XP_024302592.1  transmembrane protein 176A isoform X5

    Conserved Domains (1) summary
    pfam04103
    Location:56186
    CD20; CD20-like family
  3. XM_011516376.3XP_011514678.1  transmembrane protein 176A isoform X1

    Conserved Domains (1) summary
    pfam04103
    Location:73211
    CD20; CD20-like family
  4. XM_011516378.2XP_011514680.1  transmembrane protein 176A isoform X4

    Conserved Domains (1) summary
    pfam04103
    Location:73203
    CD20; CD20-like family
  5. XM_011516377.2XP_011514679.1  transmembrane protein 176A isoform X2

    Conserved Domains (1) summary
    pfam04103
    Location:73211
    CD20; CD20-like family
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