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CYP4F12 cytochrome P450 family 4 subfamily F member 12 [ Homo sapiens (human) ]

Gene ID: 66002, updated on 30-Sep-2020

Summary

Official Symbol
CYP4F12provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 12provided by HGNC
Primary source
HGNC:HGNC:18857
See related
Ensembl:ENSG00000186204 MIM:611485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPIVF12; F22329_1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Biased expression in small intestine (RPKM 23.2), duodenum (RPKM 22.3) and 10 other tissues See more
Orthologs

Genomic context

See CYP4F12 in Genome Data Viewer
Location:
19p13.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15673023..15698819)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15783567..15807984)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily F member 3 Neighboring gene cytochrome P450 family 4 subfamily F member 10, pseudogene Neighboring gene olfactory receptor family 10 subfamily H member 2 Neighboring gene olfactory receptor family 10 subfamily H member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alkane 1-monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
arachidonic acid epoxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
arachidonic acid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
leukotriene-B4 20-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene-B4 20-monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arachidonic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
drug metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
epoxygenase P450 pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
leukotriene B4 catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene B4 catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
menaquinone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process ISS
Inferred from Sequence or Structural Similarity
more info
 
phylloquinone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pressure natriuresis ISS
Inferred from Sequence or Structural Similarity
more info
 
renal water homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
sodium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
very long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
vitamin E metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
vitamin K catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytochrome P450 4F12
Names
cytochrome P450, family 4, subfamily F, polypeptide 12
cytochrome P450, subfamily IVF, polypeptide 12
NP_076433.3
XP_006722913.1
XP_011526504.1
XP_011526505.1
XP_011526506.1
XP_011526507.1
XP_011526509.1
XP_011526510.1
XP_016882661.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008336.2 RefSeqGene

    Range
    5012..29099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_023944.4NP_076433.3  cytochrome P450 4F12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein.
    Source sequence(s)
    AB035130, AC122702, DC418592, DR422336
    Consensus CDS
    CCDS42517.1
    UniProtKB/Swiss-Prot
    Q9HCS2
    UniProtKB/TrEMBL
    A0A0A0MR49
    Related
    ENSP00000448998.1, ENST00000550308.6
    Conserved Domains (1) summary
    pfam00067
    Location:52506
    p450; Cytochrome P450

RNA

  1. NR_117085.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and contains two additional internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB035130, AC122702, AK075435, BC034916, DC418592, DR422336
    Related
    ENST00000518629.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15673023..15698819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722850.3XP_006722913.1  cytochrome P450 4F12 isoform X2

    See identical proteins and their annotated locations for XP_006722913.1

    Conserved Domains (1) summary
    pfam00067
    Location:1357
    p450; Cytochrome P450
  2. XM_017027172.1XP_016882661.1  cytochrome P450 4F12 isoform X1

  3. XM_011528208.2XP_011526510.1  cytochrome P450 4F12 isoform X2

    See identical proteins and their annotated locations for XP_011526510.1

    Conserved Domains (1) summary
    pfam00067
    Location:1357
    p450; Cytochrome P450
  4. XM_011528202.3XP_011526504.1  cytochrome P450 4F12 isoform X2

    See identical proteins and their annotated locations for XP_011526504.1

    Conserved Domains (1) summary
    pfam00067
    Location:1357
    p450; Cytochrome P450
  5. XM_011528207.2XP_011526509.1  cytochrome P450 4F12 isoform X4

    Conserved Domains (1) summary
    pfam00067
    Location:1316
    p450; Cytochrome P450
  6. XM_011528203.2XP_011526505.1  cytochrome P450 4F12 isoform X3

    See identical proteins and their annotated locations for XP_011526505.1

    Conserved Domains (1) summary
    pfam00067
    Location:4334
    p450; Cytochrome P450
  7. XM_011528204.2XP_011526506.1  cytochrome P450 4F12 isoform X3

    See identical proteins and their annotated locations for XP_011526506.1

    Conserved Domains (1) summary
    pfam00067
    Location:4334
    p450; Cytochrome P450
  8. XM_011528205.2XP_011526507.1  cytochrome P450 4F12 isoform X3

    See identical proteins and their annotated locations for XP_011526507.1

    Conserved Domains (1) summary
    pfam00067
    Location:4334
    p450; Cytochrome P450
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