Eefsec eukaryotic elongation factor, selenocysteine-tRNA-specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eefsecprovided by MGI
Official Full Name: eukaryotic elongation factor, selenocysteine-tRNA-specificprovided by MGI
Primary source: MGI:MGI:2137092
See related: Ensembl:ENSMUSG00000033216 AllianceGenome:MGI:2137092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sec; Selb; mSelB
Summary: Enables several functions, including GTP binding activity; GTPase activity; and RNA binding activity. Acts upstream of or within selenocysteine incorporation. Located in mitochondrion. Part of ribonucleoprotein complex. Orthologous to human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 23.2), ovary adult (RPKM 18.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 D1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (88234316..88423546, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (88257334..88446552, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study examined the subcellular localization of eEFSec in the context of altered Selenocysteine incorporation to demonstrate that reduced selenoprotein production does not correlate with changes in the nuclear localization of eEFSec.
Title: The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation.
SBP2/SECIS complex activates eEFSec by directing functional interactions between Domain IV and the ribosome to promote Sec-tRNA(Sec) binding and accommodation into the ribosomal A-site
Title: The selenocysteine-specific elongation factor contains a novel and multi-functional domain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

26.MMHAP36FLA5.seq (e-PCR)
- UniSTS:123735

18.MMHAP4FLF3.seq (e-PCR)
- UniSTS:123383

Homology

Homologs of the Eefsec gene: The Eefsec gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 492 organisms have orthologs with human gene Eefsec
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables selenocysteine insertion sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables translation elongation factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in selenocysteine incorporation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within selenocysteine incorporation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within selenocysteine incorporation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: selenocysteine-specific elongation factor

Names: MJ0495-like protein SelB; elongation factor sec

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411439.1 → NP_001398368.1 selenocysteine-specific elongation factor isoform 2

Status: VALIDATED

Source sequence(s)

AC153694, AC153927

UniProtKB/TrEMBL

A0A0N4SUV6
NM_001411440.1 → NP_001398369.1 selenocysteine-specific elongation factor isoform 3

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NM_001411441.1 → NP_001398370.1 selenocysteine-specific elongation factor isoform 4

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NM_001411442.1 → NP_001398371.1 selenocysteine-specific elongation factor isoform 5

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NM_001411443.1 → NP_001398372.1 selenocysteine-specific elongation factor isoform 6

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NM_001411444.1 → NP_001398373.1 selenocysteine-specific elongation factor isoform 7

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NM_001411445.1 → NP_001398374.1 selenocysteine-specific elongation factor isoform 8

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NM_001411446.1 → NP_001398375.1 selenocysteine-specific elongation factor isoform 9

Status: VALIDATED

Source sequence(s)

AC153694
NM_001411447.1 → NP_001398376.1 selenocysteine-specific elongation factor isoform 10

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NM_001411448.1 → NP_001398377.1 selenocysteine-specific elongation factor isoform 11

Status: VALIDATED

Source sequence(s)

AC153694
NM_001411449.1 → NP_001398378.1 selenocysteine-specific elongation factor isoform 12

Status: VALIDATED

Source sequence(s)

AC153694
NM_001411450.1 → NP_001398379.1 selenocysteine-specific elongation factor isoform 13

Status: VALIDATED

Source sequence(s)

AC153694
NM_001411451.1 → NP_001398380.1 selenocysteine-specific elongation factor isoform 14

Status: VALIDATED

Source sequence(s)

AC153694
NM_023060.4 → NP_075547.1 selenocysteine-specific elongation factor isoform 1

See identical proteins and their annotated locations for NP_075547.1

Status: VALIDATED

Source sequence(s)

AC153694, AC153927

Consensus CDS

CCDS20335.1

UniProtKB/Swiss-Prot

Q6GTZ5, Q9JHW4

UniProtKB/TrEMBL

Q3UGH6

Related

ENSMUSP00000131207.2, ENSMUST00000165242.4

Conserved Domains (4) summary

cd01889
Location:8 → 197

SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome

pfam00009
Location:8 → 195

GTP_EFTU; Elongation factor Tu GTP binding domain

cd03696
Location:210 → 292

SelB_II; Domain II of elongation factor SelB

cd04094
Location:297 → 437

eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB

RNA

NR_149744.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177254.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177255.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177256.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177257.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177258.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177259.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177260.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177261.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177262.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177263.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177264.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927
NR_177265.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694
NR_177266.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153694, AC153927

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

88234316..88423546 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506465.5 → XP_006506528.1 selenocysteine-specific elongation factor isoform X1

Conserved Domains (2) summary

cd01889
Location:8 → 197

SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome

cl02787
Location:210 → 250

Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
XM_030255538.2 → XP_030111398.1 selenocysteine-specific elongation factor isoform X3

Conserved Domains (2) summary

cd04094
Location:42 → 182

eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB

cl02787
Location:1 → 37

Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
XM_030255537.2 → XP_030111397.1 selenocysteine-specific elongation factor isoform X2

Conserved Domains (2) summary

cd04094
Location:53 → 193

eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB

cl02787
Location:4 → 48

Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
XM_030255536.2 → XP_030111396.1 selenocysteine-specific elongation factor isoform X2

Conserved Domains (2) summary

cd04094
Location:53 → 193

eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB

cl02787
Location:4 → 48

Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins