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EEFSEC eukaryotic elongation factor, selenocysteine-tRNA specific [ Homo sapiens (human) ]

Gene ID: 60678, updated on 1-Jun-2020

Summary

Official Symbol
EEFSECprovided by HGNC
Official Full Name
eukaryotic elongation factor, selenocysteine-tRNA specificprovided by HGNC
Primary source
HGNC:HGNC:24614
See related
Ensembl:ENSG00000132394 MIM:607695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SELB; EFSEC
Expression
Ubiquitous expression in testis (RPKM 3.1), kidney (RPKM 2.8) and 25 other tissues See more
Orthologs

Genomic context

See EEFSEC in Genome Data Viewer
Location:
3q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (128153453..128426193)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127872302..128127489)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RUVBL1 antisense RNA 1 Neighboring gene RuvB like AAA ATPase 1 Neighboring gene RNA, U6 small nuclear 823, pseudogene Neighboring gene CRISPRi-FlowFISH-validated H1-10 regulatory element Neighboring gene CRISPRi-validated cis-regulatory element chr3.3676 Neighboring gene CRISPRi-validated cis-regulatory element chr3.3677 Neighboring gene CRISPRi-validated cis-regulatory element chr3.3678 Neighboring gene CRISPRi-validated cis-regulatory element chr3.3679 Neighboring gene CRISPRi-FlowFISH-validated RPN1 regulatory element Neighboring gene DNAJB8 antisense RNA 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member B8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
NHGRI GWA Catalog
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
 
selenocysteine insertion sequence binding IEA
Inferred from Electronic Annotation
more info
 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
selenocysteine-specific elongation factor
Names
elongation factor for selenoprotein translation
elongation factor sec
selenocysteine (Sec)-specific eukaryotic elongation factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021937.5NP_068756.2  selenocysteine-specific elongation factor

    See identical proteins and their annotated locations for NP_068756.2

    Status: VALIDATED

    Source sequence(s)
    AF268872, AL449217, BC007933, DB454660
    Consensus CDS
    CCDS33849.1
    UniProtKB/Swiss-Prot
    P57772
    Related
    ENSP00000254730.5, ENST00000254730.11
    Conserved Domains (5) summary
    cd01889
    Location:8209
    SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
    pfam00009
    Location:8213
    GTP_EFTU; Elongation factor Tu GTP binding domain
    cd03696
    Location:224306
    SelB_II; Domain II of elongation factor SelB
    cd04094
    Location:311450
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
    cl02916
    Location:505571
    POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    128153453..128426193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453695.1XP_024309463.1  selenocysteine-specific elongation factor isoform X4

    Conserved Domains (3) summary
    cd01889
    Location:8209
    SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
    cd03696
    Location:224357
    SelB_II; Domain II of elongation factor SelB
    cd04094
    Location:362501
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
  2. XM_024453694.1XP_024309462.1  selenocysteine-specific elongation factor isoform X3

    Conserved Domains (3) summary
    cd01889
    Location:8209
    SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
    cd03696
    Location:224357
    SelB_II; Domain II of elongation factor SelB
    cd04094
    Location:362501
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
  3. XM_024453692.1XP_024309460.1  selenocysteine-specific elongation factor isoform X1

    Conserved Domains (4) summary
    cd01889
    Location:8209
    SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
    cd03696
    Location:224357
    SelB_II; Domain II of elongation factor SelB
    cd04094
    Location:362501
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
    cl02916
    Location:556622
    POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases
  4. XM_024453693.1XP_024309461.1  selenocysteine-specific elongation factor isoform X2

    Conserved Domains (4) summary
    cd01889
    Location:8209
    SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
    cd03696
    Location:224356
    SelB_II; Domain II of elongation factor SelB
    cd04094
    Location:361500
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
    cl02916
    Location:555621
    POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases
  5. XM_005247696.3XP_005247753.1  selenocysteine-specific elongation factor isoform X5

    Related
    ENSP00000417660.1, ENST00000483457.1
    Conserved Domains (5) summary
    cd01889
    Location:8210
    SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
    pfam00009
    Location:8209
    GTP_EFTU; Elongation factor Tu GTP binding domain
    cd04094
    Location:256395
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
    cl02787
    Location:206251
    Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
    cl02916
    Location:450516
    POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases
  6. XM_011513066.2XP_011511368.1  selenocysteine-specific elongation factor isoform X7

    Conserved Domains (3) summary
    cd04094
    Location:42181
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
    cl02787
    Location:137
    Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
    cl02916
    Location:236302
    POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases
  7. XM_024453696.1XP_024309464.1  selenocysteine-specific elongation factor isoform X6

    Conserved Domains (3) summary
    cd04094
    Location:62201
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
    cl02787
    Location:1357
    Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
    cl02916
    Location:256322
    POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_019805490.1 Reference GRCh38.p13 PATCHES

    Range
    22577..277765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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