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SLC15A1 solute carrier family 15 member 1 [ Homo sapiens (human) ]

Gene ID: 6564, updated on 3-Sep-2017
Official Symbol
SLC15A1provided by HGNC
Official Full Name
solute carrier family 15 member 1provided by HGNC
Primary source
HGNC:HGNC:10920
See related
Ensembl:ENSG00000088386 MIM:600544; Vega:OTTHUMG00000017255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEPT1; HPECT1; HPEPT1
Summary
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
Orthologs
Location:
13q32.2-q32.3
Exon count:
23
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (98683801..98752675, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99336055..99404929, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene calmodulin 2 pseudogene 4 Neighboring gene RNA, 7SL, cytoplasmic 60, pseudogene Neighboring gene uncharacterized LOC105370330 Neighboring gene dedicator of cytokinesis 9 Neighboring gene DOCK9 antisense RNA 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptide transporter activity IEA
Inferred from Electronic Annotation
more info
 
hydrogen ion channel activity IEA
Inferred from Electronic Annotation
more info
 
peptide:proton symporter activity TAS
Traceable Author Statement
more info
 
proton-dependent oligopeptide secondary active transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
digestion TAS
Traceable Author Statement
more info
PubMed 
dipeptide transport IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
 
oligopeptide transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
proton transport IEA
Inferred from Electronic Annotation
more info
 
transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
brush border IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
solute carrier family 15 member 1
Names
Caco-2 oligopeptide transporter
intestinal H+/peptide cotransporter
macrophage oligopeptide transporter PEPT1
oligopeptide transporter, small intestine isoform
peptide transporter 1
solute carrier family 15 (oligopeptide transporter), member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017032.1 RefSeqGene

    Range
    5001..73875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005073.3NP_005064.1  solute carrier family 15 member 1

    See identical proteins and their annotated locations for NP_005064.1

    Status: REVIEWED

    Source sequence(s)
    AL708816, AW449979, BC096329, CU445953, U13173
    Consensus CDS
    CCDS9489.1
    UniProtKB/Swiss-Prot
    P46059
    UniProtKB/TrEMBL
    B2CQT6
    Related
    ENSP00000365686.4, OTTHUMP00000018599, ENST00000376503.9, OTTHUMT00000045560
    Conserved Domains (2) summary
    TIGR00926
    Location:28670
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
    pfam00854
    Location:81468
    PTR2; POT family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

    Range
    98683801..98752675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    99305811..99374685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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