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SLC14A1 solute carrier family 14 member 1 (Kidd blood group) [ Homo sapiens (human) ]

Gene ID: 6563, updated on 25-Nov-2025
Official Symbol
SLC14A1provided by HGNC
Official Full Name
solute carrier family 14 member 1 (Kidd blood group)provided by HGNC
Primary source
HGNC:HGNC:10918
See related
Ensembl:ENSG00000141469 MIM:613868; AllianceGenome:HGNC:10918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JK; UT1; UTE; HUT11; Jk(a); Jk(b); RACH1; RACH2; UT-B1; HUT11A; HsT1341
Summary
The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]
Expression
Biased expression in prostate (RPKM 18.0), urinary bladder (RPKM 11.5) and 8 other tissues See more
Orthologs
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See SLC14A1 in Genome Data Viewer
Location:
18q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (45724181..45752520)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (45915156..45943497)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (43304146..43332485)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 14 member 2 Neighboring gene SLC14A2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9415 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:42982182-42983381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13262 Neighboring gene VISTA enhancer hs1464 Neighboring gene VISTA enhancer hs1440 Neighboring gene uncharacterized LOC105372093 Neighboring gene uncharacterized LOC105372092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:43386185-43386686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:43408730-43409428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:43418307-43418808 Neighboring gene sialic acid binding Ig like lectin 15 Neighboring gene Sharpr-MPRA regulatory region 10800 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:43478156-43479355 Neighboring gene ectopic P-granules 5 autophagy tethering factor Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:43530707-43531906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:43547054-43547555 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:43557301-43557872 Neighboring gene RN7SK pseudogene 26 Neighboring gene proline-serine-threonine phosphatase interacting protein 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. A molecular genetic analysis of the Kidd blood group polymorphism in Taiwanese, Thais, and Filipinos. Liu TC, et al. Kaohsiung J Med Sci, 2001 Nov. PMID 11852461
  2. Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1. Koutros S, et al. Int J Cancer, 2013 Dec 15. PMID 23754249, Free PMC Article
  3. A novel JK*02 allele in a French Canadian family. St-Louis M, et al. Transfusion, 2013 Nov. PMID 23710545
  4. New advances in urea transporter UT-A1 membrane trafficking. Chen G. Int J Mol Sci, 2013 May 21. PMID 23698785, Free PMC Article
  5. Movement of NH₃ through the human urea transporter B: a new gas channel. Geyer RR, et al. Am J Physiol Renal Physiol, 2013 Jun 15. PMID 23552862, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC14A1 and TGF-beta signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis.
    Title: SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis.
  2. Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression.
    Title: Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression.
  3. SLC14A1 is a new biomarker in renal cancer.
    Title: SLC14A1 is a new biomarker in renal cancer.
  4. Study on the role of SLC14A1 gene in biochemical recurrence of prostate cancer.
    Title: Study on the role of SLC14A1 gene in biochemical recurrence of prostate cancer.
  5. A potential link between AQP3 and SLC14A1 gene expression level and clinical parameters of maintenance hemodialysis patients.
    Title: A potential link between AQP3 and SLC14A1 gene expression level and clinical parameters of maintenance hemodialysis patients.
  6. Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program.
    Title: Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program.
  7. SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma.
    Title: SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma.
  8. Decreased Expression of the Human Urea Transporter SLC14A1 in Bone is Induced by Cytokines and Stimulates Adipogenesis of Mesenchymal Progenitor Cells.
    Title: Decreased Expression of the Human Urea Transporter SLC14A1 in Bone is Induced by Cytokines and Stimulates Adipogenesis of Mesenchymal Progenitor Cells.
  9. A novel JK null allele in a Brazilian patient with sickle cell disease (SCD).
    Title: A novel JK null allele in a Brazilian patient with sickle cell disease (SCD).
  10. Study found that UT-B expression is decreased in human melanoma tissue. Its overexpression plays a role in tumor growth regulation of melanoma cell lines and animal transplantation models, and this, combined with findings from UT-B inhibition in bladder cancer, suggests that UT-B may have tumor suppressor functions.
    Title: Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
BLOOD GROUP, KIDD SYSTEM
MedGen: C0022645 OMIM: 111000 GeneReviews: Not available
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EBI GWAS Catalog

Description
A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3.
EBI GWAS Catalog
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of solute carrier family 14, member 1 (SLC14A1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ33745, FLJ41687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables urea channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables urea transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables urea transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables urea transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables water transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in urea transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urea transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in urea transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within urea transport IEA
Inferred from Electronic Annotation
more info
  
involved_in urea transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within water transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
urea transporter 1
Names
Kidd blood group antigen
SLC14A1 JK
mutant KIDD blood group antigen
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
urea transporter JK glycoprotein
urea transporter, erythrocyte
urea transporter-B1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011775.4 RefSeqGene

    Range
    42157..70496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_802

mRNA and Protein(s)

  1. NM_001128588.4 → NP_001122060.3  urea transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001122060.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1 and 4 both encode the same isoform (1).
    Source sequence(s)
    AC023421, AK289608, DA186606
    Consensus CDS
    CCDS45860.1
    UniProtKB/TrEMBL
    A0A7L9QHR7, F6IQ87
    Related
    ENSP00000412309.2, ENST00000415427.7
    Conserved Domains (1) summary
    pfam03253
    Location:115 → 410
    UT; Urea transporter

  2. NM_001146036.3 → NP_001139508.2  urea transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001139508.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame portion of the 5' coding sequence compared to variant 4. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AC023421, AK289608, DA186606, DA473671
    Consensus CDS
    CCDS11925.1
    UniProtKB/Swiss-Prot
    A8K0P3, B3KR62, B3KVX3, C9EHF2, Q13336, Q86VM5
    UniProtKB/TrEMBL
    A0A7L9QHR7, F6IQ87, G0W2N5
    Related
    ENSP00000465702.2, ENST00000586951.6
    Conserved Domains (1) summary
    pfam03253
    Location:59 → 354
    UT; Urea transporter

  3. NM_001146037.1 → NP_001139509.1  urea transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001139509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform.
    Source sequence(s)
    AC023421, AK091064, BC050539, DA051199
    Consensus CDS
    CCDS45860.1
    UniProtKB/TrEMBL
    A0A7L9QHR7, F6IQ87
    Related
    ENSP00000390637.2, ENST00000436407.7
    Conserved Domains (1) summary
    pfam03253
    Location:115 → 410
    UT; Urea transporter

  4. NM_001308278.2 → NP_001295207.1  urea transporter 1 isoform 3

    See identical proteins and their annotated locations for NP_001295207.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an in-frame portion of the 5' coding sequence compared to variant 4. The resulting isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC023421, AK294129, DA156178
    Consensus CDS
    CCDS82252.1
    UniProtKB/TrEMBL
    B3KXJ3, B4DFJ8, E7EQN3
    Related
    ENSP00000385320.2, ENST00000402943.6
    Conserved Domains (1) summary
    pfam03253
    Location:2 → 249
    UT; Urea transporter

  5. NM_001308279.2 → NP_001295208.1  urea transporter 1 isoform 4

    See identical proteins and their annotated locations for NP_001295208.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame portion of the 5' coding sequence compared to variant 4. The resulting isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC023421, AK295268, DA156178
    Consensus CDS
    CCDS77181.1
    UniProtKB/TrEMBL
    B4DHU3, F5GWS2, M0QX00
    Related
    ENSP00000441998.1, ENST00000535474.5
    Conserved Domains (1) summary
    pfam03253
    Location:1 → 222
    UT; Urea transporter

  6. NM_001439164.1 → NP_001426093.1  urea transporter 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC023421
    UniProtKB/TrEMBL
    A0A2I6PCQ9

  7. NM_001439165.1 → NP_001426094.1  urea transporter 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC023421
    UniProtKB/TrEMBL
    B4DHU3, F5GWS2, M0QX00
    Related
    ENSP00000466273.3, ENST00000589322.7

  8. NM_015865.7 → NP_056949.4  urea transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_056949.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame portion of the 5' coding sequence compared to variant 4. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AC023421, AV724913, DA134800, Y19039
    Consensus CDS
    CCDS11925.1
    UniProtKB/Swiss-Prot
    A8K0P3, B3KR62, B3KVX3, C9EHF2, Q13336, Q86VM5
    UniProtKB/TrEMBL
    A0A7L9QHR7, F6IQ87, G0W2N5
    Related
    ENSP00000318546.4, ENST00000321925.9
    Conserved Domains (1) summary
    pfam03253
    Location:59 → 354
    UT; Urea transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    45724181..45752520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437758.1 → XP_047293714.1  urea transporter 1 isoform X1

    UniProtKB/TrEMBL
    A0A7L9QHR7, F6IQ87

  2. XM_006722526.4 → XP_006722589.1  urea transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006722589.1

    UniProtKB/TrEMBL
    A0A7L9QHR7, F6IQ87
    Conserved Domains (1) summary
    pfam03253
    Location:94 → 389
    UT; Urea transporter

  3. XM_011526144.2 → XP_011524446.1  urea transporter 1 isoform X4

    UniProtKB/TrEMBL
    A0A2I6PCQ9
    Conserved Domains (1) summary
    pfam03253
    Location:115 → 371
    UT; Urea transporter

  4. XM_047437759.1 → XP_047293715.1  urea transporter 1 isoform X3

    UniProtKB/TrEMBL
    A0A2I6PCQ9

  5. XM_011526142.2 → XP_011524444.1  urea transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011524444.1

    UniProtKB/TrEMBL
    A0A7L9QHR7, F6IQ87
    Conserved Domains (1) summary
    pfam03253
    Location:94 → 389
    UT; Urea transporter

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    45915156..45943497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319021.1 → XP_054174996.1  urea transporter 1 isoform X1

    UniProtKB/TrEMBL
    A0A7L9QHR7

  2. XM_054319020.1 → XP_054174995.1  urea transporter 1 isoform X1

    UniProtKB/TrEMBL
    A0A7L9QHR7

  3. XM_054319024.1 → XP_054174999.1  urea transporter 1 isoform X4

    UniProtKB/TrEMBL
    A0A2I6PCQ9

  4. XM_054319023.1 → XP_054174998.1  urea transporter 1 isoform X3

    UniProtKB/TrEMBL
    A0A2I6PCQ9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13336.2 GenPept UniProtKB/Swiss-Prot:Q13336

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