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SLC8A1 solute carrier family 8 member A1 [ Homo sapiens (human) ]

Gene ID: 6546, updated on 1-Jun-2020

Summary

Official Symbol
SLC8A1provided by HGNC
Official Full Name
solute carrier family 8 member A1provided by HGNC
Primary source
HGNC:HGNC:11068
See related
Ensembl:ENSG00000183023 MIM:182305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCX1
Summary
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
Expression
Broad expression in heart (RPKM 35.6), endometrium (RPKM 9.9) and 16 other tissues See more
Orthologs

Genomic context

See SLC8A1 in Genome Data Viewer
Location:
2p22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (40094523..40512452, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (40339286..40739575, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268436 Neighboring gene zinc finger protein 19 pseudogene Neighboring gene SLC8A1 antisense RNA 1 Neighboring gene uncharacterized LOC101929667 Neighboring gene uncharacterized LOC105374473 Neighboring gene uncharacterized LOC105374475

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A Common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.
NHGRI GWA Catalog
A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.
NHGRI GWA Catalog
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
NHGRI GWA Catalog
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.
NHGRI GWA Catalog
Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults.
NHGRI GWA Catalog
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
NHGRI GWA Catalog
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
NHGRI GWA Catalog
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37694, FLJ43417, MGC119581, DKFZp779F0871

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
ankyrin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
calcium:sodium antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium:sodium antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeletal protein binding IDA
Inferred from Direct Assay
more info
PubMed 
ion antiporter activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion transport into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac muscle contraction TAS
Traceable Author Statement
more info
PubMed 
cell communication by electrical coupling involved in cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to caffeine ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular sodium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cytosolic calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
ion transport TAS
Traceable Author Statement
more info
 
membrane depolarization during cardiac muscle cell action potential TAS
Traceable Author Statement
more info
PubMed 
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of cardiac muscle contraction by calcium ion signaling TAS
Traceable Author Statement
more info
PubMed 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
Traceable Author Statement
more info
PubMed 
regulation of cell communication by electrical coupling TAS
Traceable Author Statement
more info
PubMed 
regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of the force of heart contraction IC
Inferred by Curator
more info
PubMed 
regulation of the force of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
relaxation of cardiac muscle IC
Inferred by Curator
more info
PubMed 
relaxation of cardiac muscle TAS
Traceable Author Statement
more info
PubMed 
relaxation of smooth muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
response to ATP IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
response to muscle stretch IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sodium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
telencephalon development IEA
Inferred from Electronic Annotation
more info
 
vascular smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
 
T-tubule TAS
Traceable Author Statement
more info
PubMed 
Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
axon terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
intercalated disc TAS
Traceable Author Statement
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sodium/calcium exchanger 1
Names
Na(+)/Ca(2+)-exchange protein 1
Na+/Ca++ exchanger
Na+/Ca2+ exchanger
solute carrier family 8 (sodium/calcium exchanger), member 1
solute carrier family 8 member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112800.2NP_001106271.1  sodium/calcium exchanger 1 isoform B precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377
    Consensus CDS
    CCDS46265.1
    UniProtKB/Swiss-Prot
    P32418
    UniProtKB/TrEMBL
    Q4QQH3
    Related
    ENSP00000385678.3, ENST00000405901.7
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4968
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:795959
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  2. NM_001112801.3NP_001106272.1  sodium/calcium exchanger 1 isoform C precursor

    See identical proteins and their annotated locations for NP_001106272.1

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4960
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:787951
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  3. NM_001112802.2NP_001106273.1  sodium/calcium exchanger 1 isoform D precursor

    See identical proteins and their annotated locations for NP_001106273.1

    Status: VALIDATED

    Source sequence(s)
    AC007254, AK291696
    Consensus CDS
    CCDS46264.1
    UniProtKB/Swiss-Prot
    P32418
    Related
    ENSP00000385188.1, ENST00000402441.5
    Conserved Domains (1) summary
    TIGR00845
    Location:4937
    caca; sodium/calcium exchanger 1
  4. NM_001252624.2NP_001239553.1  sodium/calcium exchanger 1 isoform E precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377
    Consensus CDS
    CCDS59430.1
    UniProtKB/Swiss-Prot
    P32418
    Related
    ENSP00000384908.2, ENST00000408028.6
    Conserved Domains (1) summary
    TIGR00845
    Location:4965
    caca; sodium/calcium exchanger 1
  5. NM_001351483.2NP_001338412.1  sodium/calcium exchanger 1 isoform F precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4945
    caca; sodium/calcium exchanger 1
  6. NM_001351484.2NP_001338413.1  sodium/calcium exchanger 1 isoform F precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4945
    caca; sodium/calcium exchanger 1
  7. NM_001351485.2NP_001338414.1  sodium/calcium exchanger 1 isoform F precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4945
    caca; sodium/calcium exchanger 1
  8. NM_001351486.2NP_001338415.1  sodium/calcium exchanger 1 isoform G precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4944
    caca; sodium/calcium exchanger 1
  9. NM_001351487.2NP_001338416.1  sodium/calcium exchanger 1 isoform H precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4961
    caca; sodium/calcium exchanger 1
  10. NM_001351488.2NP_001338417.1  sodium/calcium exchanger 1 isoform H precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4961
    caca; sodium/calcium exchanger 1
  11. NM_001351489.2NP_001338418.1  sodium/calcium exchanger 1 isoform H precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4961
    caca; sodium/calcium exchanger 1
  12. NM_001351490.2NP_001338419.1  sodium/calcium exchanger 1 isoform I precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4938
    caca; sodium/calcium exchanger 1
  13. NM_001351491.2NP_001338420.1  sodium/calcium exchanger 1 isoform I precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4938
    caca; sodium/calcium exchanger 1
  14. NM_001351492.2NP_001338421.1  sodium/calcium exchanger 1 isoform I precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC106048
    Conserved Domains (1) summary
    TIGR00845
    Location:4938
    caca; sodium/calcium exchanger 1
  15. NM_001351493.2NP_001338422.1  sodium/calcium exchanger 1 isoform E precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Consensus CDS
    CCDS59430.1
    Conserved Domains (1) summary
    TIGR00845
    Location:4965
    caca; sodium/calcium exchanger 1
  16. NM_001351494.2NP_001338423.1  sodium/calcium exchanger 1 isoform D precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Consensus CDS
    CCDS46264.1
    Related
    ENSP00000383886.1, ENST00000406785.6
    Conserved Domains (1) summary
    TIGR00845
    Location:4937
    caca; sodium/calcium exchanger 1
  17. NM_001372263.1NP_001359192.1  sodium/calcium exchanger 1 isoform A precursor

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877
  18. NM_021097.4NP_066920.1  sodium/calcium exchanger 1 isoform A precursor

    See identical proteins and their annotated locations for NP_066920.1

    Status: VALIDATED

    Source sequence(s)
    AC007254, AC007281, AC007377, AC007877, AC106048
    Consensus CDS
    CCDS1806.1
    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    40094523..40512452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712083.4XP_006712146.1  sodium/calcium exchanger 1 isoform X2

    See identical proteins and their annotated locations for XP_006712146.1

    UniProtKB/Swiss-Prot
    P32418
    Related
    ENSP00000384763.1, ENST00000403092.5
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  2. XM_006712082.4XP_006712145.1  sodium/calcium exchanger 1 isoform X2

    See identical proteins and their annotated locations for XP_006712145.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  3. XM_017004749.2XP_016860238.1  sodium/calcium exchanger 1 isoform X2

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  4. XM_017004751.2XP_016860240.1  sodium/calcium exchanger 1 isoform X2

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  5. XM_017004750.2XP_016860239.1  sodium/calcium exchanger 1 isoform X2

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  6. XM_017004752.2XP_016860241.1  sodium/calcium exchanger 1 isoform X2

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  7. XM_006712085.4XP_006712148.1  sodium/calcium exchanger 1 isoform X2

    See identical proteins and their annotated locations for XP_006712148.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  8. XM_017004755.2XP_016860244.1  sodium/calcium exchanger 1 isoform X6

    Conserved Domains (1) summary
    TIGR00845
    Location:4961
    caca; sodium/calcium exchanger 1
  9. XM_011533055.3XP_011531357.1  sodium/calcium exchanger 1 isoform X2

    See identical proteins and their annotated locations for XP_011531357.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  10. XM_006712084.4XP_006712147.1  sodium/calcium exchanger 1 isoform X2

    See identical proteins and their annotated locations for XP_006712147.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  11. XM_017004745.2XP_016860234.1  sodium/calcium exchanger 1 isoform X1

  12. XM_011533056.2XP_011531358.1  sodium/calcium exchanger 1 isoform X2

    See identical proteins and their annotated locations for XP_011531358.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  13. XM_017004746.2XP_016860235.1  sodium/calcium exchanger 1 isoform X2

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  14. XM_017004753.2XP_016860242.1  sodium/calcium exchanger 1 isoform X2

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  15. XM_011533054.3XP_011531356.1  sodium/calcium exchanger 1 isoform X2

    See identical proteins and their annotated locations for XP_011531356.1

    UniProtKB/Swiss-Prot
    P32418
    Related
    ENSP00000332931.4, ENST00000332839.8
    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:800964
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  16. XM_011533050.2XP_011531352.1  sodium/calcium exchanger 1 isoform X3

    Conserved Domains (5) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4966
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:793957
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  17. XM_011533058.2XP_011531360.1  sodium/calcium exchanger 1 isoform X7

    Related
    ENSP00000386116.2, ENST00000407929.6
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    pfam01699
    Location:80251
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
    pfam16494
    Location:254384
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  18. XM_017004764.1XP_016860253.1  sodium/calcium exchanger 1 isoform X8

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