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SLC8A2 solute carrier family 8 member A2 [ Homo sapiens (human) ]

Gene ID: 6543, updated on 21-Dec-2019

Summary

Official Symbol
SLC8A2provided by HGNC
Official Full Name
solute carrier family 8 member A2provided by HGNC
Primary source
HGNC:HGNC:11069
See related
Ensembl:ENSG00000118160 MIM:601901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCX2
Expression
Biased expression in brain (RPKM 19.6), endometrium (RPKM 1.5) and 1 other tissue See more
Orthologs

Genomic context

See SLC8A2 in Genome Data Viewer
Location:
19q13.32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47428017..47471893, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47931274..47975307, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DExH-box helicase 34 Neighboring gene Meis homeobox 3 Neighboring gene kaptin, actin binding protein Neighboring gene NAPA antisense RNA 1 Neighboring gene NSF attachment protein alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium:sodium antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
cell communication IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
ion transport TAS
Traceable Author Statement
more info
 
learning ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
memory ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of short-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
sodium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/calcium exchanger 2
Names
Na(+)/Ca(2+)-exchange protein 2
Na+/Ca2+-exchanging protein Nac2
solute carrier family 8 (sodium/calcium exchanger), member 2
solute carrier family 8 member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015063.3NP_055878.1  sodium/calcium exchanger 2 precursor

    See identical proteins and their annotated locations for NP_055878.1

    Status: VALIDATED

    Source sequence(s)
    AB029010, AC073548, DC401065
    Consensus CDS
    CCDS33065.1
    UniProtKB/Swiss-Prot
    Q9UPR5
    Related
    ENSP00000236877.5, ENST00000236877.11
    Conserved Domains (1) summary
    TIGR00845
    Location:1921
    caca; sodium/calcium exchanger 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47428017..47471893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259172.2XP_005259229.1  sodium/calcium exchanger 2 isoform X1

    Conserved Domains (5) summary
    smart00237
    Location:522612
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:1915
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:741906
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:393482
    Calx-beta; Calx-beta domain
    pfam16494
    Location:248373
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  2. XM_017027159.1XP_016882648.1  sodium/calcium exchanger 2 isoform X2

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