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SLC8A2 solute carrier family 8 member A2 [ Homo sapiens (human) ]

Gene ID: 6543, updated on 22-Sep-2022

Summary

Official Symbol
SLC8A2provided by HGNC
Official Full Name
solute carrier family 8 member A2provided by HGNC
Primary source
HGNC:HGNC:11069
See related
Ensembl:ENSG00000118160 MIM:601901; AllianceGenome:HGNC:11069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCX2
Summary
Predicted to enable calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Predicted to be involved in several processes, including inorganic cation transmembrane transport; learning or memory; and regulation of short-term neuronal synaptic plasticity. Predicted to act upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Part of presynapse. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 19.6), endometrium (RPKM 1.5) and 1 other tissue See more
Orthologs
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Genomic context

See SLC8A2 in Genome Data Viewer
Location:
19q13.32
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47428017..47471893, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50258872..50302744, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47931274..47975150, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DExH-box helicase 34 Neighboring gene Meis homeobox 3 Neighboring gene hESC enhancers GRCh37_chr19:47931091-47931659 and GRCh37_chr19:47931660-47932227 Neighboring gene Sharpr-MPRA regulatory region 169 Neighboring gene NAPA antisense RNA 1 Neighboring gene kaptin, actin binding protein Neighboring gene NSF attachment protein alpha Neighboring gene zinc finger protein 541

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium:sodium antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium:sodium antiporter activity TAS
Traceable Author Statement
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sodium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion export across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ion transport TAS
Traceable Author Statement
more info
 
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in metal ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within modulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of action potential firing pattern ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of regulation of calcineurin-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of short-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axon terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IC
Inferred by Curator
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sodium/calcium exchanger 2
Names
Na(+)/Ca(2+)-exchange protein 2
Na+/Ca2+-exchanging protein Nac2
solute carrier family 8 (sodium/calcium exchanger), member 2
solute carrier family 8 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015063.3NP_055878.1  sodium/calcium exchanger 2 precursor

    See identical proteins and their annotated locations for NP_055878.1

    Status: VALIDATED

    Source sequence(s)
    AB029010, AC073548, DC401065
    Consensus CDS
    CCDS33065.1
    UniProtKB/Swiss-Prot
    B4DYQ9, Q9UPR5
    Related
    ENSP00000236877.5, ENST00000236877.11
    Conserved Domains (1) summary
    TIGR00845
    Location:1921
    caca; sodium/calcium exchanger 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    47428017..47471893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    50258872..50302744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)