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Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 [ Mus musculus (house mouse) ]

Gene ID: 110891, updated on 9-May-2024

Summary

Official Symbol
Slc8a2provided by MGI
Official Full Name
solute carrier family 8 (sodium/calcium exchanger), member 2provided by MGI
Primary source
MGI:MGI:107996
See related
Ensembl:ENSMUSG00000030376 AllianceGenome:MGI:107996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ncx2
Summary
Enables calcium:sodium antiporter activity. Involved in several processes, including inorganic cation transmembrane transport; learning or memory; and regulation of short-term neuronal synaptic plasticity. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Located in axon terminus and postsynaptic density. Is integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex mantle layer; embryo; and olfactory cortex mantle layer. Orthologous to human SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 30.5), frontal lobe adult (RPKM 22.5) and 8 other tissues See more
Orthologs
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Genomic context

See Slc8a2 in Genome Data Viewer
Location:
7 A2; 7 8.75 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15861540..15894988)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16127592..16161063)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E541 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein alpha Neighboring gene STARR-positive B cell enhancer ABC_E6515 Neighboring gene kaptin Neighboring gene Meis homeobox 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16786573-16786682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16792577-16792686 Neighboring gene DExH-box helicase 34 Neighboring gene STARR-positive B cell enhancer ABC_E1334

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in calcium ion export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within modulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of action potential firing pattern IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of calcineurin-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sodium/calcium exchanger 2
Names
Na(+)/Ca(2+)-exchange protein 2
solute carrier family 8 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347561.1NP_001334490.1  sodium/calcium exchanger 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    BC058704, BC080277, BY731737
    Consensus CDS
    CCDS85220.1
    UniProtKB/Swiss-Prot
    Q8K596
    Related
    ENSMUSP00000128926.3, ENSMUST00000168693.3
  2. NM_148946.3NP_683748.1  sodium/calcium exchanger 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_683748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC058704, BY731737
    Consensus CDS
    CCDS20845.1
    UniProtKB/Swiss-Prot
    Q68EG0, Q8K596, Q8R504
    Related
    ENSMUSP00000147497.2, ENSMUST00000211649.2
    Conserved Domains (5) summary
    smart00237
    Location:522612
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:1921
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:748912
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:393482
    Calx-beta; Calx-beta domain
    pfam16494
    Location:248368
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    15861540..15894988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539471.5XP_006539534.1  sodium/calcium exchanger 2 isoform X1

    Conserved Domains (1) summary
    TIGR00845
    Location:1828
    caca; sodium/calcium exchanger 1

RNA

  1. XR_004933995.1 RNA Sequence