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TMEM236 transmembrane protein 236 [ Homo sapiens (human) ]

Gene ID: 653567, updated on 3-Apr-2024

Summary

Official Symbol
TMEM236provided by HGNC
Official Full Name
transmembrane protein 236provided by HGNC
Primary source
HGNC:HGNC:23473
See related
Ensembl:ENSG00000148483 AllianceGenome:HGNC:23473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM23A; FAM23B; bA16O1.2; bA162I21.2
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: In the NCBI Build 37.2 reference assembly, TMEM236 (FAM23A) and FAM23B are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. The clone on which FAM23B was based (AL928729) will be removed from the reference assembly and only TMEM236 will be present in the assembly. [13 Feb 2013]
Expression
Biased expression in small intestine (RPKM 7.1), duodenum (RPKM 4.6) and 2 other tissues See more
Orthologs
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Genomic context

See TMEM236 in Genome Data Viewer
Location:
10p12.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17752201..17800868)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17771505..17820200)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17794200..17842867)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17685104-17685752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:17685753-17686402 Neighboring gene STAM divergent transcript Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:17713088-17713842 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:17715682-17716218 Neighboring gene signal transducing adaptor molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:17728822-17729322 Neighboring gene MPRA-validated peak889 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17829359-17829976 Neighboring gene mannose receptor C-type 1 Neighboring gene microRNA 511 Neighboring gene uncharacterized LOC124902600

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ59050

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 236
Names
family with sequence similarity 23, member A
family with sequence similarity 23, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098844.3NP_001092314.1  transmembrane protein 236

    See identical proteins and their annotated locations for NP_001092314.1

    Status: VALIDATED

    Source sequence(s)
    AL139238, BC157856, BX097915
    Consensus CDS
    CCDS41492.1
    UniProtKB/Swiss-Prot
    B2RXH7, Q5W0B7
    Related
    ENSP00000366715.1, ENST00000377495.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    17752201..17800868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016574.2XP_016872063.1  transmembrane protein 236 isoform X1

    UniProtKB/TrEMBL
    B4DU14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    17771505..17820200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366644.1XP_054222619.1  transmembrane protein 236 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013629.1: Suppressed sequence

    Description
    NM_001013629.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.