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TMEM236 transmembrane protein 236 [ Homo sapiens (human) ]

Gene ID: 653567, updated on 9-Jun-2025
Official Symbol
TMEM236provided by HGNC
Official Full Name
transmembrane protein 236provided by HGNC
Primary source
HGNC:HGNC:23473
See related
Ensembl:ENSG00000148483 AllianceGenome:HGNC:23473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM23A; FAM23B; bA16O1.2; bA162I21.2
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jun 2025]
Annotation information
Note: In the NCBI Build 37.2 reference assembly, TMEM236 (FAM23A) and FAM23B are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. The clone on which FAM23B was based (AL928729) will be removed from the reference assembly and only TMEM236 will be present in the assembly. [13 Feb 2013]
Expression
Biased expression in small intestine (RPKM 7.1), duodenum (RPKM 4.6) and 2 other tissues See more
Orthologs
mouse all
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See TMEM236 in Genome Data Viewer
Location:
10p12.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17752201..17800868)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17771505..17820200)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17794200..17842867)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17685104-17685752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:17685753-17686402 Neighboring gene STAM divergent transcript Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:17713088-17713842 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:17715682-17716218 Neighboring gene signal transducing adaptor molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:17728822-17729322 Neighboring gene MPRA-validated peak889 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17829359-17829976 Neighboring gene mannose receptor C-type 1 Neighboring gene microRNA 511 Neighboring gene uncharacterized LOC124902600

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Transcriptome profiling by combined machine learning and statistical R analysis identifies TMEM236 as a potential novel diagnostic biomarker for colorectal cancer. Maurya NS, et al. Sci Rep, 2021 Jul 12. PMID 34253750, Free PMC Article
  2. Genome-wide association study of hematological and biochemical traits in a Japanese population. Kamatani Y, et al. Nat Genet, 2010 Mar. PMID 20139978
  3. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  4. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ59050

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transmembrane protein 236
Names
family with sequence similarity 23, member A
family with sequence similarity 23, member B

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098844.3 → NP_001092314.1  transmembrane protein 236

    See identical proteins and their annotated locations for NP_001092314.1

    Status: VALIDATED

    Source sequence(s)
    AL139238, BC157856, BX097915
    Consensus CDS
    CCDS41492.1
    UniProtKB/Swiss-Prot
    B2RXH7, Q5W0B7
    Related
    ENSP00000366715.1, ENST00000377495.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    17752201..17800868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016574.2 → XP_016872063.1  transmembrane protein 236 isoform X1

    UniProtKB/TrEMBL
    B4DU14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    17771505..17820200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366644.1 → XP_054222619.1  transmembrane protein 236 isoform X1

    UniProtKB/TrEMBL
    B4DU14

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013629.1: Suppressed sequence

    Description
    NM_001013629.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5W0B7.1 GenPept UniProtKB/Swiss-Prot:Q5W0B7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials