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WNK4 WNK lysine deficient protein kinase 4 [ Homo sapiens (human) ]

Gene ID: 65266, updated on 23-Sep-2022

Summary

Official Symbol
WNK4provided by HGNC
Official Full Name
WNK lysine deficient protein kinase 4provided by HGNC
Primary source
HGNC:HGNC:14544
See related
Ensembl:ENSG00000126562 MIM:601844; AllianceGenome:HGNC:14544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHA2B; PRKWNK4
Summary
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
Expression
Biased expression in kidney (RPKM 12.8), prostate (RPKM 5.7) and 6 other tissues See more
Orthologs
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Genomic context

See WNK4 in Genome Data Viewer
Location:
17q21.2
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42780610..42797066)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43637750..43654206)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40932628..40949084)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RAMP2 antisense RNA 1 Neighboring gene receptor activity modifying protein 2 Neighboring gene Sharpr-MPRA regulatory region 12532 Neighboring gene vacuolar protein sorting 25 homolog Neighboring gene cytochrome c oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chloride channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride ion binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in aldosterone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular cation homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular chloride ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in distal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in macrophage activation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of pancreatic juice secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in renal sodium ion absorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in renal sodium ion absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase WNK4
Names
protein kinase lysine-deficient 4
protein kinase with no lysine 4
NP_001308228.1
NP_115763.2
XP_016880451.1
XP_016880455.1
XP_047292510.1
XP_047292512.1
XP_047292513.1
XP_047292514.1
XP_047292515.1
XP_047292516.1
XP_047292517.1
XP_047292518.1
XP_047292519.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016227.1 RefSeqGene

    Range
    4980..21436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321299.2NP_001308228.1  serine/threonine-protein kinase WNK4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC100793, BC144356, BM683764, CA388932
    Conserved Domains (1) summary
    pfam12202
    Location:117153
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. NM_032387.5NP_115763.2  serine/threonine-protein kinase WNK4 isoform 1

    See identical proteins and their annotated locations for NP_115763.2

    Status: REVIEWED

    Source sequence(s)
    AC100793, BC136664, BM683764, CA388932
    Consensus CDS
    CCDS11439.1
    UniProtKB/Swiss-Prot
    Q96J92, Q9BYS5
    Related
    ENSP00000246914.4, ENST00000246914.10
    Conserved Domains (3) summary
    smart00220
    Location:179432
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14033
    Location:172432
    STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
    pfam12202
    Location:453489
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    42780610..42797066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024962.2XP_016880451.1  serine/threonine-protein kinase WNK4 isoform X1

  2. XM_047436559.1XP_047292515.1  serine/threonine-protein kinase WNK4 isoform X6

  3. XM_047436554.1XP_047292510.1  serine/threonine-protein kinase WNK4 isoform X2

  4. XM_047436558.1XP_047292514.1  serine/threonine-protein kinase WNK4 isoform X5

  5. XM_047436560.1XP_047292516.1  serine/threonine-protein kinase WNK4 isoform X7

  6. XM_047436556.1XP_047292512.1  serine/threonine-protein kinase WNK4 isoform X3

  7. XM_047436561.1XP_047292517.1  serine/threonine-protein kinase WNK4 isoform X8

  8. XM_047436563.1XP_047292519.1  serine/threonine-protein kinase WNK4 isoform X10

  9. XM_047436557.1XP_047292513.1  serine/threonine-protein kinase WNK4 isoform X4

  10. XM_047436562.1XP_047292518.1  serine/threonine-protein kinase WNK4 isoform X9

  11. XM_017024966.2XP_016880455.1  serine/threonine-protein kinase WNK4 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    43637750..43654206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)