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mapk14a mitogen-activated protein kinase 14a [ Danio rerio (zebrafish) ]

Gene ID: 65237, updated on 6-Jan-2026
Official Symbol
mapk14aprovided by ZNC
Official Full Name
mitogen-activated protein kinase 14aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010202-2
See related
Ensembl:ENSDARG00000000857 AllianceGenome:ZFIN:ZDB-GENE-010202-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p38; p38a; zp38a; MAPK14; fk28c03; zeh1243; hm:zeh1243; wu:fk28c03
Summary
Enables MAP kinase activity. Involved in cellular response to UV; embryonic cleavage; and p38MAPK cascade. Acts upstream of or within regulation of collateral sprouting in absence of injury; regulation of protein stability; and somitogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See mapk14a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 8 NC_133183.1 (25722827..25756005)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23827541..23860719)

Chromosome 8 - NC_133183.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 276 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator 1 Neighboring gene basal body orientation factor 1a Neighboring gene SRSF protein kinase 1a Neighboring gene LHFPL tetraspan subfamily member 5b Neighboring gene copine Va

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. p38α MAPK regulates myocardial regeneration in zebrafish. Jopling C, et al. Cell Cycle, 2012 Mar 15. PMID 22391208, Free PMC Article
  2. P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish. Taylor HB, et al. Immunol Cell Biol, 2013 Jan. PMID 23165607, Free PMC Article
  3. Asymmetric p38 activation in zebrafish: its possible role in symmetric and synchronous cleavage. Fujii R, et al. J Cell Biol, 2000 Sep 18. PMID 10995439, Free PMC Article
  4. PHR regulates growth cone pausing at intermediate targets through microtubule disassembly. Hendricks M, et al. J Neurosci, 2009 May 20. PMID 19458229, Free PMC Article
  5. Molecular components underlying nongenomic thyroid hormone signaling in embryonic zebrafish neurons. Yonkers MA, et al. Neural Dev, 2009 Jun 8. PMID 19505305, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
    Title: P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
  2. Adult zebrafish cardiomyocytes express active p38alpha MAPK, which is switched off upon entry into mitosis.
    Title: p38α MAPK regulates myocardial regeneration in zebrafish.
  3. Dkk3r regulates p38a phosphorylation to maintain Smad4 stability, in turn enabling the Smad2.Smad3a.Smad4 complex to form and activate the myf5 promoter.
    Title: dickkopf-3-related gene regulates the expression of zebrafish myf5 gene through phosphorylated p38a-dependent Smad4 activity.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
  
involved_in embryonic cleavage IDA
Inferred from Direct Assay
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in p38MAPK cascade IDA
Inferred from Direct Assay
more info
  
involved_in p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
mitogen-activated protein kinase 14A
Names
MAP kinase 14A
MAP kinase p38a
MAPK 14A
etID18993.8
mitogen-activated protein kinase p38a
NP_571797.1
XP_005167118.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131722.1 → NP_571797.1  mitogen-activated protein kinase 14A

    See identical proteins and their annotated locations for NP_571797.1

    Status: PROVISIONAL

    Source sequence(s)
    AB030897
    UniProtKB/Swiss-Prot
    Q9DGE1, Q9DGE2
    UniProtKB/TrEMBL
    B2GPM7
    Related
    ENSDARP00000040361.4, ENSDART00000040362.5
    Conserved Domains (2) summary
    cd07877
    Location:7 → 351
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    smart00220
    Location:25 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133183.1 Reference GRCz12tu Primary Assembly

    Range
    25722827..25756005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167061.5 → XP_005167118.1  mitogen-activated protein kinase 14A isoform X1

    UniProtKB/TrEMBL
    A0A2R8QE41, A0A8M2BEF0
    Related
    ENSDARP00000147688.1, ENSDART00000187430.1
    Conserved Domains (2) summary
    cd07877
    Location:7 → 351
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    smart00220
    Location:25 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RNA

  1. XR_012383817.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DGE2.1 GenPept UniProtKB/Swiss-Prot:Q9DGE2

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