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mapk14a mitogen-activated protein kinase 14a [ Danio rerio (zebrafish) ]

Gene ID: 65237, updated on 28-Apr-2024

Summary

Official Symbol
mapk14aprovided by ZNC
Official Full Name
mitogen-activated protein kinase 14aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010202-2
See related
Ensembl:ENSDARG00000000857 AllianceGenome:ZFIN:ZDB-GENE-010202-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
p38; p38a; zp38a; MAPK14; fk28c03; zeh1243; hm:zeh1243; wu:fk28c03
Summary
Enables MAP kinase activity. Involved in cellular response to UV; embryonic cleavage; and p38MAPK cascade. Acts upstream of or within regulation of collateral sprouting in absence of injury; regulation of protein stability; and somitogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; otic vesicle; and pronephric duct. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See mapk14a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23827441..23860719)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23806189..23839480)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator 1 Neighboring gene basal body orientation factor 1a Neighboring gene SRSF protein kinase 1a Neighboring gene LHFPL tetraspan subfamily member 5b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
 
involved_in embryonic cleavage IDA
Inferred from Direct Assay
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in p38MAPK cascade IDA
Inferred from Direct Assay
more info
 
acts_upstream_of_or_within p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 14A
Names
MAP kinase 14A
MAP kinase p38a
MAPK 14A
etID18993.8
mitogen-activated protein kinase p38a
NP_571797.1
XP_005167118.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131722.1NP_571797.1  mitogen-activated protein kinase 14A

    See identical proteins and their annotated locations for NP_571797.1

    Status: PROVISIONAL

    Source sequence(s)
    AB030897
    UniProtKB/Swiss-Prot
    Q9DGE1, Q9DGE2
    UniProtKB/TrEMBL
    B2GPM7
    Related
    ENSDARP00000040361.4, ENSDART00000040362.5
    Conserved Domains (2) summary
    cd07877
    Location:7351
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    smart00220
    Location:25309
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    23827441..23860719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167061.4XP_005167118.1  mitogen-activated protein kinase 14A isoform X1

    UniProtKB/TrEMBL
    A0A2R8QE41, A0A8M2BEF0
    Related
    ENSDARP00000147688.1, ENSDART00000187430.1
    Conserved Domains (2) summary
    cd07877
    Location:7351
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    smart00220
    Location:25309
    S_TKc; Serine/Threonine protein kinases, catalytic domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394724.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    80447..114580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)