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SLC2A5 solute carrier family 2 member 5 [ Homo sapiens (human) ]

Gene ID: 6518, updated on 13-Mar-2020

Summary

Official Symbol
SLC2A5provided by HGNC
Official Full Name
solute carrier family 2 member 5provided by HGNC
Primary source
HGNC:HGNC:11010
See related
Ensembl:ENSG00000142583 MIM:138230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT5; GLUT-5
Summary
The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
Expression
Biased expression in duodenum (RPKM 33.7), small intestine (RPKM 25.5) and 8 other tissues See more
Orthologs

Genomic context

See SLC2A5 in Genome Data Viewer
Location:
1p36.23
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (9035106..9072259, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9097005..9131763, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 451, pseudogene Neighboring gene solute carrier family 2 member 7 Neighboring gene G protein-coupled receptor 157 Neighboring gene MIR34A host gene Neighboring gene microRNA 34a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fructose binding ISS
Inferred from Sequence or Structural Similarity
more info
 
fructose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
fructose transmembrane transporter activity TAS
Traceable Author Statement
more info
 
glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to fructose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
fructose import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
fructose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
glucose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
intestinal hexose absorption TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
regulation of systemic arterial blood pressure mediated by a chemical signal ISS
Inferred from Sequence or Structural Similarity
more info
 
response to fructose ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 5
Names
glucose transporter type 5, small intestine
glucose transporter-like protein 5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
testicular tissue protein Li 81

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050918.1 RefSeqGene

    Range
    26149..63302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135585.2NP_001129057.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 2

    See identical proteins and their annotated locations for NP_001129057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL158048, BC035878, DC379829
    Consensus CDS
    CCDS44054.1
    UniProtKB/Swiss-Prot
    P22732
    UniProtKB/TrEMBL
    A0A140VJK5
    Related
    ENSP00000366631.3, ENST00000377414.7
    Conserved Domains (1) summary
    cl26863
    Location:23194
    Sugar_tr; Sugar (and other) transporter
  2. NM_001328619.2NP_001315548.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL158048
    Consensus CDS
    CCDS99.1
    UniProtKB/Swiss-Prot
    P22732
    Conserved Domains (1) summary
    pfam00083
    Location:23475
    Sugar_tr; Sugar (and other) transporter
  3. NM_001328620.2NP_001315549.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL158048
    UniProtKB/TrEMBL
    B4DG19
    Conserved Domains (2) summary
    cd06174
    Location:28416
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:22431
    Sugar_tr; Sugar (and other) transporter
  4. NM_001328621.2NP_001315550.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate coding exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL158048
  5. NM_003039.3NP_003030.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 1

    See identical proteins and their annotated locations for NP_003030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL158048, CA309754, DC379829, M55531
    Consensus CDS
    CCDS99.1
    UniProtKB/Swiss-Prot
    P22732
    Related
    ENSP00000366641.4, ENST00000377424.9
    Conserved Domains (1) summary
    pfam00083
    Location:23475
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    9035106..9072259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024180.1: Suppressed sequence

    Description
    NR_024180.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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