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Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 [ Mus musculus (house mouse) ]

Gene ID: 56485, updated on 8-Feb-2024

Summary

Official Symbol
Slc2a5provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 5provided by MGI
Primary source
MGI:MGI:1928369
See related
Ensembl:ENSMUSG00000028976 AllianceGenome:MGI:1928369
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut5; Slc5a
Summary
Enables fructose transmembrane transporter activity. Involved in cellular response to fructose stimulus; fructose import across plasma membrane; and regulation of systemic arterial blood pressure mediated by a chemical signal. Located in apical plasma membrane. Is expressed in central nervous system and metanephros. Orthologous to human SLC2A5 (solute carrier family 2 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 204.2), kidney adult (RPKM 46.2) and 2 other tissues See more
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Genomic context

See Slc2a5 in Genome Data Viewer
Location:
4 E2; 4 80.97 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150203801..150228625)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150119344..150144168)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene microRNA 34a Neighboring gene STARR-positive B cell enhancer mm9_chr4:149461240-149461541 Neighboring gene G protein-coupled receptor 157 Neighboring gene STARR-seq mESC enhancer starr_12136 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149512225-149512526 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 7 Neighboring gene predicted gene, 52492 Neighboring gene carbonic anhydrase 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC32452

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fructose binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fructose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fructose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 5
Names
GLUT-5
fructose transporter
glucose transporter type 5, small intestine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019741.3NP_062715.2  solute carrier family 2, facilitated glucose transporter member 5

    See identical proteins and their annotated locations for NP_062715.2

    Status: PROVISIONAL

    Source sequence(s)
    AK029720
    Consensus CDS
    CCDS18968.1
    UniProtKB/Swiss-Prot
    Q8R1N7, Q9WV38
    Related
    ENSMUSP00000030826.3, ENSMUST00000030826.4
    Conserved Domains (1) summary
    cd17432
    Location:22470
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    150203801..150228625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539076.5XP_006539139.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    See identical proteins and their annotated locations for XP_006539139.1

    UniProtKB/Swiss-Prot
    Q8R1N7, Q9WV38
    Conserved Domains (1) summary
    cd17432
    Location:22470
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily