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Prrg2 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 65116, updated on 2-Nov-2024

Summary

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Official Symbol
Prrg2provided by MGI
Official Full Name
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2provided by MGI
Primary source
MGI:MGI:1929596
See related
Ensembl:ENSMUSG00000007837 AllianceGenome:MGI:1929596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N4WBP1; 1600014G02Rik; 2510041M06Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human PRRG2 (proline rich and Gla domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 35.9), stomach adult (RPKM 25.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Prrg2 in Genome Data Viewer
Location:
7 B3; 7 29.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44703008..44711828, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45053584..45062672, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E130 Neighboring gene STARR-positive B cell enhancer ABC_E871 Neighboring gene related RAS viral (r-ras) oncogene Neighboring gene proline rich 12 Neighboring gene STARR-positive B cell enhancer ABC_E6541 Neighboring gene STARR-positive B cell enhancer ABC_E2235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840 Neighboring gene nitric oxide synthase interacting protein Neighboring gene reticulocalbin 3, EF-hand calcium binding domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Jolliffe CN, et al. Biochem J, 2000 Nov 1. PMID 11042109, Free PMC Article
  2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transmembrane gamma-carboxyglutamic acid protein 2
Names
NEDD4 WW domain-binding protein 1
proline-rich Gla protein 2
proline-rich gamma-carboxyglutamic acid protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419032.1 → NP_001405961.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126256
    Related
    ENSMUSP00000147844.2, ENSMUST00000210493.2

  2. NM_001419033.1 → NP_001405962.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126256
    UniProtKB/Swiss-Prot
    Q8R182, Q9EQI2
    Related
    ENSMUSP00000148014.2, ENSMUST00000210690.2

  3. NM_001419034.1 → NP_001405963.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC126256
    UniProtKB/Swiss-Prot
    Q8R182, Q9EQI2
    Related
    ENSMUSP00000147977.2, ENSMUST00000211014.2

  4. NM_001419035.1 → NP_001405964.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126256

  5. NM_001419036.1 → NP_001405965.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126256

  6. NM_022999.2 → NP_075375.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_075375.1

    Status: VALIDATED

    Source sequence(s)
    AC126256
    Consensus CDS
    CCDS21227.1
    UniProtKB/Swiss-Prot
    Q8R182, Q9EQI2
    UniProtKB/TrEMBL
    A0A1B0GSK7
    Related
    ENSMUSP00000007981.4, ENSMUST00000007981.9
    Conserved Domains (1) summary
    smart00069
    Location:33 → 97
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

RNA

  1. NR_185003.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126256

  2. NR_185004.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126256

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44703008..44711828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R182.1 GenPept UniProtKB/Swiss-Prot:Q8R182

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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