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PRRG2 proline rich and Gla domain 2 [ Homo sapiens (human) ]

Gene ID: 5639, updated on 20-Mar-2020

Summary

Official Symbol
PRRG2provided by HGNC
Official Full Name
proline rich and Gla domain 2provided by HGNC
Primary source
HGNC:HGNC:9470
See related
Ensembl:ENSG00000126460 MIM:604429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRGP2
Summary
The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression
Broad expression in duodenum (RPKM 5.0), thyroid (RPKM 4.3) and 18 other tissues See more
Orthologs

Genomic context

See PRRG2 in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49580617..49591008)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50084574..50094272)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene reticulocalbin 3 Neighboring gene nitric oxide synthase interacting protein Neighboring gene proline rich 12 Neighboring gene RAS related

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transmembrane gamma-carboxyglutamic acid protein 2
Names
proline rich Gla (G-carboxyglutamic acid) 2
proline-rich Gla (G-carboxglutamic acid) polypeptide 2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
proline-rich Gla protein 2
proline-rich gamma-carboxyglutamic acid protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000951.3NP_000942.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000942.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010619, AF009243, CB851486, CD609900
    Consensus CDS
    CCDS12773.1
    UniProtKB/Swiss-Prot
    O14669
    Related
    ENSP00000246794.4, ENST00000246794.10
    Conserved Domains (2) summary
    cd12087
    Location:109138
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    smart00069
    Location:2895
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
  2. NM_001316335.2NP_001303264.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction near the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC010619, CB851486, CD013954, CD609900
    Related
    ENST00000543867.2
    Conserved Domains (2) summary
    cd12087
    Location:86115
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    smart00069
    Location:572
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49580617..49591008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723286.2XP_006723349.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006723349.1

    UniProtKB/Swiss-Prot
    O14669
    Conserved Domains (2) summary
    cd12087
    Location:109138
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    smart00069
    Location:2895
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
  2. XM_011527124.1XP_011525426.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011525426.1

    Conserved Domains (2) summary
    cd12087
    Location:86115
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    smart00069
    Location:572
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
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