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Pmepa1 prostate transmembrane protein, androgen induced 1 [ Mus musculus (house mouse) ]

Gene ID: 65112, updated on 8-Feb-2024

Summary

Official Symbol
Pmepa1provided by MGI
Official Full Name
prostate transmembrane protein, androgen induced 1provided by MGI
Primary source
MGI:MGI:1929600
See related
Ensembl:ENSMUSG00000038400 AllianceGenome:MGI:1929600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stag1; Erg1.2; N4wbp4; Tmepai; 2210418I02Rik
Summary
Predicted to enable R-SMAD binding activity and WW domain binding activity. Involved in negative regulation of pathway-restricted SMAD protein phosphorylation and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be active in Golgi membrane and early endosome membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Orthologous to human PMEPA1 (prostate transmembrane protein, androgen induced 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 17.4), ovary adult (RPKM 16.8) and 23 other tissues See more
Orthologs
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Genomic context

See Pmepa1 in Genome Data Viewer
Location:
2 H3; 2 95.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173066251..173118329, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173224458..173276731, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9076 Neighboring gene phosphoenolpyruvate carboxykinase 1, cytosolic Neighboring gene Z-DNA binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_06613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:173055154-173055337 Neighboring gene STARR-seq mESC enhancer starr_06615 Neighboring gene prostate transmembrane protein, androgen induced 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_06620 Neighboring gene predicted gene, 46780

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables R-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein TMEPAI
Names
NEDD4 WW domain-binding protein 4
Nedd4 WW binding protein 4
transmembrane prostate androgen-induced protein
transmembrane, prostate androgen induced RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413585.1NP_001400514.1  protein TMEPAI isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL837509
    UniProtKB/Swiss-Prot
    Q9D7R2, Q9EQH9
  2. NM_001413590.1NP_001400519.1  protein TMEPAI isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL837509, AL837520
    UniProtKB/TrEMBL
    Q4QRN6
  3. NM_022995.4NP_075371.2  protein TMEPAI isoform 2

    See identical proteins and their annotated locations for NP_075371.2

    Status: VALIDATED

    Source sequence(s)
    AL837509, AL837520
    Consensus CDS
    CCDS38350.1
    UniProtKB/TrEMBL
    A2APF4, Q4QRN6
    Related
    ENSMUSP00000039950.7, ENSMUST00000036248.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    173066251..173118329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)