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PMEPA1 prostate transmembrane protein, androgen induced 1 [ Homo sapiens (human) ]

Gene ID: 56937, updated on 7-Oct-2018

Summary

Official Symbol
PMEPA1provided by HGNC
Official Full Name
prostate transmembrane protein, androgen induced 1provided by HGNC
Primary source
HGNC:HGNC:14107
See related
Ensembl:ENSG00000124225 MIM:606564; Vega:OTTHUMG00000032831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAG1; TMEPAI
Summary
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in prostate (RPKM 54.2), fat (RPKM 28.9) and 20 other tissues See more
Orthologs

Genomic context

See PMEPA1 in Genome Data Viewer
Location:
20q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (57648392..57711536, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (56223448..56286592, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372690 Neighboring gene Z-DNA binding protein 1 Neighboring gene uncharacterized LOC105372692 Neighboring gene NF-kappaB interacting lncRNA Neighboring gene uncharacterized LOC105372693

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of prostate transmembrane protein, androgen induced 1 (PMEPA1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein prostate transmembrane protein, androgen induced 1 (PMEPA1) in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Downregulation of TGF-beta receptor signaling, organism-specific biosystem (from REACTOME)
    Downregulation of TGF-beta receptor signaling, organism-specific biosystemTGF-beta receptor signaling is downregulated by proteasome and lysosome-mediated degradation of ubiquitinated TGFBR1, SMAD2 and SMAD3, as well as by dephosphorylation of TGFBR1, SMAD2 and SMAD3. In t...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
    Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
  • TGF-beta receptor signaling activates SMADs, organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling activates SMADs, organism-specific biosystemBinding of transforming growth factor beta 1 (TGF beta 1, i.e. TGFB1) to TGF beta receptor type 2 (TGFBR2) activates TGF beta receptor signaling cascade. TGFB1 is posttranslationally processed by fur...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane TAS
Traceable Author Statement
more info
 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein TMEPAI
Names
solid tumor-associated 1 protein
transmembrane, prostate androgen induced RNA

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031951.1 RefSeqGene

    Range
    5001..68145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001255976.1NP_001242905.1  protein TMEPAI isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF305616, BQ008707, BU196912
    UniProtKB/Swiss-Prot
    Q969W9
    Related
    ENSP00000401506.1, OTTHUMP00000174283, ENST00000414037.5, OTTHUMT00000267813
  2. NM_020182.4NP_064567.2  protein TMEPAI isoform a

    See identical proteins and their annotated locations for NP_064567.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF305616, BM846677, BQ008707
    Consensus CDS
    CCDS13463.1
    UniProtKB/Swiss-Prot
    Q969W9
    Related
    ENSP00000345826.3, OTTHUMP00000031379, ENST00000341744.7, OTTHUMT00000079858
  3. NM_199169.2NP_954638.1  protein TMEPAI isoform b

    See identical proteins and their annotated locations for NP_954638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF224278, AF305616, AK296199, BQ008707
    Consensus CDS
    CCDS13462.1
    UniProtKB/Swiss-Prot
    Q969W9
    UniProtKB/TrEMBL
    Q5JY37
    Related
    ENSP00000344014.4, OTTHUMP00000031380, ENST00000347215.8, OTTHUMT00000079859
  4. NM_199170.2NP_954639.1  protein TMEPAI isoform c precursor

    See identical proteins and their annotated locations for NP_954639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AF305616, AK296199, AY128643, BQ008707
    Consensus CDS
    CCDS13464.1
    UniProtKB/Swiss-Prot
    Q969W9
    UniProtKB/TrEMBL
    Q5JY37
    Related
    ENSP00000379161.3, OTTHUMP00000174285, ENST00000395816.7, OTTHUMT00000267815
    Conserved Domains (1) summary
    cl21455
    Location:102159
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_199171.2NP_954640.1  protein TMEPAI isoform c precursor

    See identical proteins and their annotated locations for NP_954640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AF305616, AL732104, AL732105, BQ008707
    Consensus CDS
    CCDS13464.1
    UniProtKB/Swiss-Prot
    Q969W9
    Related
    ENSP00000265626.4, ENST00000265626.8
    Conserved Domains (1) summary
    cl21455
    Location:102159
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    57648392..57711536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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