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SLA Src like adaptor [ Homo sapiens (human) ]

Gene ID: 6503, updated on 6-Jun-2017
Official Symbol
SLAprovided by HGNC
Official Full Name
Src like adaptorprovided by HGNC
Primary source
HGNC:HGNC:10902
See related
Ensembl:ENSG00000155926 MIM:601099; Vega:OTTHUMG00000164439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLA1; SLAP
Orthologs
mouse all
Location:
8q24.22
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (133036728..133103360, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (134048973..134115604, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene thyroglobulin Neighboring gene uncharacterized LOC105375768 Neighboring gene ribosomal protein L21 pseudogene 78 Neighboring gene microRNA 7848 Neighboring gene uncharacterized LOC105375769 Neighboring gene uncharacterized LOC102723635 Neighboring gene WNT1 inducible signaling pathway protein 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Related articles in PubMed

  1. Intracellular cytoplasm-specific delivery of SH3 and SH2 domains of SLAP inhibits TcR-mediated signaling. Kim JH, et al. Biochem Biophys Res Commun, 2015 May 8. PMID 25800872
  2. Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia. Mansha M, et al. Leuk Res, 2010 Apr. PMID 19631983
  3. The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene. Meijerink PH, et al. Eur J Biochem, 1998 Jun 1. PMID 9660183
  4. Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid. Ohtsuki T, et al. Biochem Biophys Res Commun, 1997 Jan 3. PMID 9020066
  5. The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease. Marton N, et al. Mediators Inflamm, 2015. PMID 26339145, Free PMC Article

See all (38) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. results suggest that cytoplasm-specific transduction of the SH3 and SH2 domains of SLAP has a therapeutic potential of being an immunosuppressive reagent for the treatment of various autoimmune diseases
    Title: Intracellular cytoplasm-specific delivery of SH3 and SH2 domains of SLAP inhibits TcR-mediated signaling.
  2. Taken together the data demonstrate that SLAP negatively regulates wild-type c-Kit signaling, but not its oncogenic counterpart, indicating a possible mechanism by which the oncogenic c-Kit bypasses the normal cellular negative feedback control
    Title: Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling.
  3. upon ligand stimulation SLAP stably associates with Flt3 through multiple phosphotyrosine residues in Flt3. SLAP mRNA is differentially expressed in different cancers and its expression significantly increased in patients carrying the Flt3-ITD mutation
    Title: Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.
  4. These data provide evidence for src-like adaptor protein-dependent regulation of CD3 zeta-chain in the fine control of TCR signaling.
    Title: CD3ζ-chain expression of human T lymphocytes is regulated by TNF via Src-like adaptor protein-dependent proteasomal degradation.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Although SLA is a prominent glucocorticoids response gene, it does not seem to contribute to the anti-leukemic effects of glucocorticoids.
    Title: Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
  8. The SLA molecule and its functionally relevant residues have been highly conserved throughout the evolution.
    Title: Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
NHGRI GWA Catalog
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
NHGRI GWA Catalog
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
NHGRI GWA Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3/SH2 adaptor activity IEA
Inferred from Electronic Annotation
more info
  
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
endosome IEA
Inferred from Electronic Annotation
more info
  
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
src-like-adapter
Names
SLAP-1
hSLAP
src-like-adapter protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045556.2 → NP_001039021.1  src-like-adapter isoform a

    See identical proteins and their annotated locations for NP_001039021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (a).
    Source sequence(s)
    AK312584, BX648382, D89077, DB265860, DC313073, U44403
    Consensus CDS
    CCDS6370.1
    UniProtKB/Swiss-Prot
    Q13239
    Related
    ENSP00000337548.5, OTTHUMP00000226704, ENST00000338087.9, OTTHUMT00000378771
    Conserved Domains (2) summary
    cd10344
    Location:73 → 170
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:26 → 80
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

  2. NM_001045557.2 → NP_001039022.2  src-like-adapter isoform b

    See identical proteins and their annotated locations for NP_001039022.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon and uses an upstream translation initiation codon, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AF305872, BX648382, DC313073, U44403
    Consensus CDS
    CCDS47922.1
    UniProtKB/Swiss-Prot
    Q13239
    Related
    ENSP00000378759.3, OTTHUMP00000226706, ENST00000395352.7, OTTHUMT00000378773
    Conserved Domains (2) summary
    cd10344
    Location:90 → 187
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:43 → 97
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

  3. NM_001282964.1 → NP_001269893.1  src-like-adapter isoform d

    See identical proteins and their annotated locations for NP_001269893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the centtral coding region compared to variant 1. These differences result in the use of an upstream start codon compared to varian 1. The encoded isoform (d) is shorter but has an extended N-terminus compare to isoform a.
    Source sequence(s)
    AF235100, AF305872, AK297423, AW137142
    Consensus CDS
    CCDS64978.1
    UniProtKB/Swiss-Prot
    Q13239
    Related
    ENSP00000428559.1, OTTHUMP00000226708, ENST00000517648.5, OTTHUMT00000378776
    Conserved Domains (2) summary
    cd12010
    Location:43 → 97
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein
    cl15255
    Location:90 → 134
    SH2; Src homology 2 (SH2) domain

  4. NM_001282965.1 → NP_001269894.1  src-like-adapter isoform e

    See identical proteins and their annotated locations for NP_001269894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 5' UTR which results in the use of an downstream start codon compared to variant 1. The encodoed isoform (e) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AF235100, AF305872, AK297519, AW137142
    Consensus CDS
    CCDS64977.1
    UniProtKB/Swiss-Prot
    Q13239
    Related
    ENSP00000427928.1, OTTHUMP00000226707, ENST00000524345.5, OTTHUMT00000378775
    Conserved Domains (1) summary
    cl15255
    Location:1 → 62
    SH2; Src homology 2 (SH2) domain

  5. NM_006748.3 → NP_006739.2  src-like-adapter isoform c

    See identical proteins and their annotated locations for NP_006739.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AF305872, BC007042, BX648382, DA999385, U44403
    Consensus CDS
    CCDS47923.1
    UniProtKB/Swiss-Prot
    Q13239
    Related
    ENSP00000394049.2, OTTHUMP00000226705, ENST00000427060.6, OTTHUMT00000378772
    Conserved Domains (2) summary
    cd10344
    Location:113 → 210
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:66 → 120
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

    Range
    133036728..133103360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013739.1 → XP_016869228.1  src-like-adapter isoform X1

    UniProtKB/Swiss-Prot
    Q13239
    Conserved Domains (1) summary
    cl15255
    Location:1 → 62
    SH2; Src homology 2 (SH2) domain

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    134089636..134155921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13239.3 GenPept UniProtKB/Swiss-Prot:Q13239

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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