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Sla src-like adaptor [ Mus musculus (house mouse) ]

Gene ID: 20491, updated on 24-Sep-2025
Official Symbol
Slaprovided by MGI
Official Full Name
src-like adaptorprovided by MGI
Primary source
MGI:MGI:104295
See related
Ensembl:ENSMUSG00000022372 AllianceGenome:MGI:104295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slap; Slap-1
Summary
Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in endosome. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; hemolymphoid system; and musculoskeletal system. Orthologous to human SLA (Src like adaptor). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in thymus adult (RPKM 31.9), spleen adult (RPKM 9.7) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Sla in Genome Data Viewer
Location:
15 D2; 15 29.3 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (66652713..66703921, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (66780819..66831829, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 71 Neighboring gene STARR-positive B cell enhancer mm9_chr15:66392494-66392795 Neighboring gene PHD finger protein 20-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr15:66511565-66511866 Neighboring gene thyroglobulin Neighboring gene STARR-positive B cell enhancer mm9_chr15:66616909-66617209 Neighboring gene STARR-positive B cell enhancer ABC_E5484 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:66650248-66650357 Neighboring gene VISTA enhancer mm104 Neighboring gene STARR-positive B cell enhancer ABC_E5485 Neighboring gene predicted gene, 46514 Neighboring gene cellular communication network factor 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. SRC-like adaptor protein regulates B cell development and function. Dragone LL, et al. J Immunol, 2006 Jan 1. PMID 16365426
  2. Cutting edge: dexamethasone negatively regulates Syk in mast cells by up-regulating SRC-like adaptor protein. Hiragun T, et al. J Immunol, 2006 Aug 15. PMID 16887961
  3. Src-like adaptor protein regulates osteoclast generation and survival. Kim HJ, et al. J Cell Biochem, 2010 May. PMID 20225239, Free PMC Article
  4. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. Kratchmarova I, et al. Gene, 2001 Jan 10. PMID 11179692
  5. SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response. Sharma N, et al. Front Immunol, 2019. PMID 31156621, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLAP Is a Negative Regulator of FcepsilonRI Receptor-Mediated Signaling and Allergic Response.
    Title: SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response.
  2. SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke
    Title: SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.
  3. SLAP is a critical regulator of B-cell development and function and its deficiency leads to decreased autoreactive B cells that are otherwise maintained by inefficient receptor editing or failed negative selection.
    Title: SLAP deficiency decreases dsDNA autoantibody production.
  4. Src-like adaptor protein (SLAP) functions as a negative regulator of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) generation of monocyte-derived dendritic cells of bone marrow origin.
    Title: The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.
  5. SLAP deficiency dramatically reduces both the incidence and severity of arthritis and prevents development of chronic arthritis in the double SKG (mutant ZAP70) Src-like adapter protein (SLAP) knockout mouse model.
    Title: SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.
  6. SLAP negatively regulates differentiation of osteoclasts and proliferation of their precursors.
    Title: Src-like adaptor protein regulates osteoclast generation and survival.
  7. SLAP has a conserved function in B and T cells by adapting c-Cbl to the antigen-receptor complex and targeting it for degradation
    Title: Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.
  8. SLAP functions in a pathway that requires the phosphorylated TCRzeta chain and the Src family kinase Lck, but not ZAP-70 (zeta-associated protein of 70 kD).
    Title: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
src-like-adapter
Names
src-like-adapter protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029841.5 → NP_001025012.1  src-like-adapter isoform a

    See identical proteins and their annotated locations for NP_001025012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC107859, AC157560
    Consensus CDS
    CCDS49622.1
    UniProtKB/TrEMBL
    A0A0R4J247
    Related
    ENSMUSP00000131865.2, ENSMUST00000168522.2
    Conserved Domains (2) summary
    cd10344
    Location:89 → 186
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:42 → 96
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

  2. NM_001411767.1 → NP_001398696.1  src-like-adapter isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, skips a coding exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC107859, AC157560

  3. NM_009192.4 → NP_033218.1  src-like-adapter isoform b

    See identical proteins and their annotated locations for NP_033218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC107859, AC157560
    Consensus CDS
    CCDS27509.1
    UniProtKB/Swiss-Prot
    Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8
    UniProtKB/TrEMBL
    Q4FJX0
    Related
    ENSMUSP00000127901.2, ENSMUST00000164163.8
    Conserved Domains (2) summary
    cd10344
    Location:73 → 170
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:26 → 80
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    66652713..66703921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159288.1 → XP_036015181.1  src-like-adapter isoform X2

    UniProtKB/Swiss-Prot
    Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8
    UniProtKB/TrEMBL
    Q4FJX0
    Conserved Domains (2) summary
    cd10344
    Location:73 → 170
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:26 → 80
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

  2. XM_030248433.2 → XP_030104293.1  src-like-adapter isoform X2

    UniProtKB/Swiss-Prot
    Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8
    UniProtKB/TrEMBL
    Q4FJX0
    Conserved Domains (2) summary
    cd10344
    Location:73 → 170
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:26 → 80
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein

  3. XM_017316522.3 → XP_017172011.1  src-like-adapter isoform X1

    Related
    ENSMUSP00000130222.2, ENSMUST00000168589.8
    Conserved Domains (2) summary
    cd10344
    Location:112 → 209
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cd12010
    Location:65 → 119
    SH3_SLAP; Src homology 3 domain of Src-Like Adaptor Protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60898.3 GenPept UniProtKB/Swiss-Prot:Q60898

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