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RANBP17 RAN binding protein 17 [ Homo sapiens (human) ]

Gene ID: 64901, updated on 1-Jun-2020

Summary

Official Symbol
RANBP17provided by HGNC
Official Full Name
RAN binding protein 17provided by HGNC
Primary source
HGNC:HGNC:14428
See related
Ensembl:ENSG00000204764 MIM:606141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Expression
Broad expression in testis (RPKM 1.6), thyroid (RPKM 0.5) and 15 other tissues See more
Orthologs

Genomic context

See RANBP17 in Genome Data Viewer
Location:
5q35.1
Exon count:
37
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (170862018..171300015)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (170288880..170727454)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986475 Neighboring gene gamma-aminobutyric acid type A receptor subunit pi Neighboring gene RNA, 7SL, cytoplasmic 623, pseudogene Neighboring gene tubulin epsilon 1 pseudogene Neighboring gene VISTA enhancer hs608 Neighboring gene VISTA enhancer hs693 Neighboring gene VISTA enhancer hs278 Neighboring gene USP12 pseudogene 1 Neighboring gene ribosomal protein L19 pseudogene 10 Neighboring gene T cell leukemia homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAN binding protein 17 (RANBP17) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32916

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding NAS
Non-traceable Author Statement
more info
PubMed 
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022897.5NP_075048.1  ran-binding protein 17

    See identical proteins and their annotated locations for NP_075048.1

    Status: VALIDATED

    Source sequence(s)
    AC091980, AJ271459, DC404010
    Consensus CDS
    CCDS34287.1
    UniProtKB/Swiss-Prot
    Q9H2T7
    UniProtKB/TrEMBL
    Q546R4
    Related
    ENSP00000427975.1, ENST00000523189.6
    Conserved Domains (1) summary
    pfam03810
    Location:3095
    IBN_N; Importin-beta N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    170862018..171300015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534627.1XP_011532929.1  ran-binding protein 17 isoform X1

    Conserved Domains (1) summary
    pfam03810
    Location:3095
    IBN_N; Importin-beta N-terminal domain
  2. XM_017009738.1XP_016865227.1  ran-binding protein 17 isoform X3

  3. XM_017009739.1XP_016865228.1  ran-binding protein 17 isoform X4

  4. XM_017009736.1XP_016865225.1  ran-binding protein 17 isoform X2

  5. XM_017009740.1XP_016865229.1  ran-binding protein 17 isoform X5

  6. XM_017009741.2XP_016865230.1  ran-binding protein 17 isoform X6

  7. XM_017009742.2XP_016865231.1  ran-binding protein 17 isoform X7

  8. XM_017009744.1XP_016865233.1  ran-binding protein 17 isoform X9

  9. XM_011534636.2XP_011532938.1  ran-binding protein 17 isoform X11

    Related
    ENSP00000429298.1, ENST00000519256.5
    Conserved Domains (1) summary
    pfam03810
    Location:3095
    IBN_N; Importin-beta N-terminal domain
  10. XM_011534637.2XP_011532939.1  ran-binding protein 17 isoform X13

    Related
    ENSP00000373770.4, ENST00000389118.8
    Conserved Domains (1) summary
    pfam03810
    Location:3095
    IBN_N; Importin-beta N-terminal domain
  11. XM_017009746.2XP_016865235.1  ran-binding protein 17 isoform X12

    UniProtKB/TrEMBL
    Q8IVM9
    Related
    ENSP00000430958.1, ENST00000522066.5
    Conserved Domains (1) summary
    pfam03810
    Location:3095
    IBN_N; Importin-beta N-terminal domain
  12. XM_017009743.1XP_016865232.1  ran-binding protein 17 isoform X8

  13. XM_017009745.1XP_016865234.1  ran-binding protein 17 isoform X10

  14. XM_017009747.1XP_016865236.1  ran-binding protein 17 isoform X14

RNA

  1. XR_001742202.1 RNA Sequence

  2. XR_941108.2 RNA Sequence

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