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Lpin2 lipin 2 [ Mus musculus (house mouse) ]

Gene ID: 64898, updated on 8-Dec-2022

Summary

Official Symbol
Lpin2provided by MGI
Official Full Name
lipin 2provided by MGI
Primary source
MGI:MGI:1891341
See related
Ensembl:ENSMUSG00000024052 AllianceGenome:MGI:1891341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610511G02Rik
Summary
Enables phosphatidate phosphatase activity and transcription coactivator activity. Involved in lipid metabolic process and positive regulation of transcription by RNA polymerase II. Located in cytosol and endoplasmic reticulum membrane. Is expressed in central nervous system; gonad; liver; lung; and retina. Orthologous to human LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 8.0), liver E18 (RPKM 7.6) and 28 other tissues See more
Orthologs
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Genomic context

See Lpin2 in Genome Data Viewer
Location:
17; 17 E1.3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71490527..71556813)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71183532..71249818)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53974 Neighboring gene myomesin 1 Neighboring gene elastin microfibril interfacer 2 Neighboring gene RIKEN cDNA 4930471L23 gene Neighboring gene ubiquitin specific peptidase 16 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidate phosphatase LPIN2
NP_001158357.1
NP_001344720.1
NP_075020.2
XP_006524849.1
XP_006524851.1
XP_030105837.1
XP_030105838.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164885.1NP_001158357.1  phosphatidate phosphatase LPIN2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC126942, AC154218, AW489885
    Consensus CDS
    CCDS50177.1
    UniProtKB/TrEMBL
    E9PWN0
    Related
    ENSMUSP00000118610.2, ENSMUST00000126681.8
    Conserved Domains (3) summary
    pfam04571
    Location:39144
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:672897
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:504594
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  2. NM_001357791.1NP_001344720.1  phosphatidate phosphatase LPIN2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126942, AC154218, AW489885
    Consensus CDS
    CCDS28956.1
    UniProtKB/Swiss-Prot
    Q8CHR7
    UniProtKB/TrEMBL
    A0A8C6GET7
    Conserved Domains (3) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  3. NM_022882.4NP_075020.2  phosphatidate phosphatase LPIN2 isoform 2

    See identical proteins and their annotated locations for NP_075020.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC126942, AC154218, AW489885
    Consensus CDS
    CCDS28956.1
    UniProtKB/Swiss-Prot
    Q8CHR7, Q99PI5
    UniProtKB/TrEMBL
    A0A8C6GET7
    Related
    ENSMUSP00000119282.2, ENSMUST00000129635.8
    Conserved Domains (3) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    71490527..71556813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249977.1XP_030105837.1  phosphatidate phosphatase LPIN2 isoform X3

    Conserved Domains (3) summary
    pfam04571
    Location:164
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:602827
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:434524
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  2. XM_030249978.2XP_030105838.1  phosphatidate phosphatase LPIN2 isoform X4

    Conserved Domains (2) summary
    pfam08235
    Location:373598
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:205295
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  3. XM_006524786.4XP_006524849.1  phosphatidate phosphatase LPIN2 isoform X1

    Conserved Domains (3) summary
    pfam04571
    Location:39102
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:640865
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:472562
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  4. XM_006524788.4XP_006524851.1  phosphatidate phosphatase LPIN2 isoform X2

    See identical proteins and their annotated locations for XP_006524851.1

    UniProtKB/Swiss-Prot
    Q8CHR7, Q99PI5
    UniProtKB/TrEMBL
    A0A8C6GET7
    Conserved Domains (3) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain