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Lpin2 lipin 2 [ Mus musculus (house mouse) ]

Gene ID: 64898, updated on 27-Aug-2019

Summary

Official Symbol
Lpin2provided by MGI
Official Full Name
lipin 2provided by MGI
Primary source
MGI:MGI:1891341
See related
Ensembl:ENSMUSG00000024052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI481352; AW742896; 2610511G02Rik
Expression
Ubiquitous expression in lung adult (RPKM 8.0), liver E18 (RPKM 7.6) and 28 other tissues See more
Orthologs

Genomic context

See Lpin2 in Genome Data Viewer
Location:
17; 17 E1.3
Exon count:
23
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71183532..71249818)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (71533318..71599158)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene myosin, light chain 12A, regulatory, non-sarcomeric Neighboring gene myomesin 1 Neighboring gene elastin microfibril interfacer 2 Neighboring gene RIKEN cDNA 4930471L23 gene Neighboring gene ubiquitin specific peptidase 16 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidate phosphatase LPIN2
NP_001158357.1
NP_001344720.1
NP_075020.2
XP_006524849.1
XP_006524851.1
XP_030105837.1
XP_030105838.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164885.1NP_001158357.1  phosphatidate phosphatase LPIN2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC126942, AC154218, AW489885
    Consensus CDS
    CCDS50177.1
    UniProtKB/TrEMBL
    E9PWN0
    Related
    ENSMUSP00000118610.1, ENSMUST00000126681.7
    Conserved Domains (3) summary
    pfam04571
    Location:39144
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:672897
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:504594
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  2. NM_001357791.1NP_001344720.1  phosphatidate phosphatase LPIN2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126942, AC154218, AW489885
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  3. NM_022882.4NP_075020.2  phosphatidate phosphatase LPIN2 isoform 2

    See identical proteins and their annotated locations for NP_075020.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC126942, AC154218, AW489885
    Consensus CDS
    CCDS28956.1
    UniProtKB/Swiss-Prot
    Q99PI5
    Related
    ENSMUSP00000119282.1, ENSMUST00000129635.7
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p6 C57BL/6J

    Range
    71183532..71249818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249977.1XP_030105837.1  phosphatidate phosphatase LPIN2 isoform X3

  2. XM_030249978.1XP_030105838.1  phosphatidate phosphatase LPIN2 isoform X4

  3. XM_006524786.3XP_006524849.1  phosphatidate phosphatase LPIN2 isoform X1

    Conserved Domains (3) summary
    pfam04571
    Location:39102
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:640865
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:472562
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  4. XM_006524788.3XP_006524851.1  phosphatidate phosphatase LPIN2 isoform X2

    See identical proteins and their annotated locations for XP_006524851.1

    UniProtKB/Swiss-Prot
    Q99PI5
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:634859
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:466556
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
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