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MARCHF7 membrane associated ring-CH-type finger 7 [ Homo sapiens (human) ]

Gene ID: 64844, updated on 3-Nov-2024

Summary

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Official Symbol
MARCHF7provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 7provided by HGNC
Primary source
HGNC:HGNC:17393
See related
Ensembl:ENSG00000136536 MIM:613334; AllianceGenome:HGNC:17393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXO; AXOT; MARCH7; RNF177; MARCH-VII
Summary
MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]
Expression
Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 28.8) and 25 other tissues See more
Orthologs
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Genomic context

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See MARCHF7 in Genome Data Viewer
Location:
2q24.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159712506..159771027)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (160169869..160228395)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160569017..160627538)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160472595-160473121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160480245-160480746 Neighboring gene BAZ2B antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160568592-160569258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12044 Neighboring gene RPS3A pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160594100-160595092 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53909 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53950 Neighboring gene LY75-CD302 readthrough Neighboring gene uncharacterized LOC124906083 Neighboring gene CD302 molecule Neighboring gene lymphocyte antigen 75 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16695 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160761228-160761469

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells. Szigyarto CA, et al. J Histochem Cytochem, 2010 Apr. PMID 19901269, Free PMC Article
  2. Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer. Singh S, et al. Med Oncol, 2022 Dec 30. PMID 36583798
  3. Identification of novel interactions between host and non-structural protein 2C of foot-and-mouth disease virus. Mahajan S, et al. J Gen Virol, 2021 Mar. PMID 33729124
  4. Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination. Shi X, et al. Autophagy, 2024 Mar. PMID 37915253, Free PMC Article
  5. Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer. Zhang L, et al. Tohoku J Exp Med, 2016 Jul. PMID 27302477

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
    Title: Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
  2. Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer.
    Title: Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer.
  3. Identification of novel interactions between host and non-structural protein 2C of foot-and-mouth disease virus.
    Title: Identification of novel interactions between host and non-structural protein 2C of foot-and-mouth disease virus.
  4. Data show that miR-27b-3p inhibited ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7) in endometrial cancer (EC) cells and MARCH7 promoted cell invasion through snail transcription factors (Snail)-mediated pathway.
    Title: miR-27b-3p/MARCH7 regulates invasion and metastasis of endometrial cancer cells through Snail-mediated pathway.
  5. The findings uncover a novel mechanism for the regulation of Mdm2 and reveal MARCH7 as an important regulator of the Mdm2-p53 pathway.
    Title: Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.
  6. USP7 and MARCH7 are involved in the progression of Epithelial ovarian cancer.
    Title: Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.
  7. Axotrophin/MARCH-7 has an expression profile that is distinct from that of other MARCH family members.
    Title: The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.
  8. MARCH7 can be stabilized by both USP9X and USP7, which deubiquitylate MARCH7 in the cytosol and nucleus, respectively
    Title: The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X.
  9. Data suggest that clinical auto-graft versus host disease inversely correlates with axotrophin transcript expression.
    Title: Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp586F1122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MDM2/MDM4 family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cilium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tolerance induction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF7
Names
E3 ubiquitin-protein ligase MARCH7
RING finger protein 177
RING-type E3 ubiquitin transferase MARCH7
RING-type E3 ubiquitin transferase MARCHF7
axotrophin
membrane associated ring finger 7
membrane-associated RING finger protein 7
membrane-associated RING-CH protein VII
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
NP_001269734.1
NP_001269735.1
NP_001269736.1
NP_001363163.1
NP_001363164.1
NP_001363165.1
NP_001363166.1
NP_001363167.1
NP_001363168.1
NP_001363169.1
NP_001363170.1
NP_001363171.1
NP_001363172.1
NP_001363173.1
NP_001363174.1
NP_001363175.1
NP_001363176.1
NP_001363177.1
NP_001363178.1
NP_001363179.1
NP_001363180.1
NP_001363181.1
NP_001363182.1
NP_001363183.1
NP_001363184.1
NP_073737.1
XP_016860210.1
XP_047301464.1
XP_047301467.1
XP_047301469.1
XP_047301470.1
XP_047301471.1
XP_047301472.1
XP_047301473.1
XP_047301474.1
XP_047301475.1
XP_047301476.1
XP_047301477.1
XP_047301479.1
XP_047301480.1
XP_047301481.1
XP_047301482.1
XP_047301483.1
XP_047301484.1
XP_047301485.1
XP_047301486.1
XP_054199378.1
XP_054199379.1
XP_054199380.1
XP_054199381.1
XP_054199382.1
XP_054199383.1
XP_054199384.1
XP_054199385.1
XP_054199386.1
XP_054199387.1
XP_054199388.1
XP_054199389.1
XP_054199390.1
XP_054199391.1
XP_054199392.1
XP_054199393.1
XP_054199394.1
XP_054199395.1
XP_054199396.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282805.2 → NP_001269734.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    See identical proteins and their annotated locations for NP_001269734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 5-13 all encode the same isoform (a).
    Source sequence(s)
    AC009961, AI863394, AK292836, AK316382, BC003404
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Related
    ENSP00000386830.1, ENST00000409175.6
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_001282806.2 → NP_001269735.1  E3 ubiquitin-protein ligase MARCHF7 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS63038.1
    UniProtKB/TrEMBL
    B7Z5K0, F5H6W4
    Related
    ENSP00000442992.1, ENST00000539065.5
    Conserved Domains (1) summary
    smart00744
    Location:496 → 552
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  3. NM_001282807.2 → NP_001269736.1  E3 ubiquitin-protein ligase MARCHF7 isoform c

    See identical proteins and their annotated locations for NP_001269736.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009961, AI863394, AK302347, AK316382, BC003404
    Consensus CDS
    CCDS63039.1
    UniProtKB/TrEMBL
    B7ZAR7
    Related
    ENSP00000387238.1, ENST00000409591.5
    Conserved Domains (1) summary
    smart00744
    Location:514 → 570
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  4. NM_001376234.1 → NP_001363163.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, and 6-13, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  5. NM_001376235.1 → NP_001363164.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 5, and 7-13, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  6. NM_001376236.1 → NP_001363165.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 5, 6, and 8-13, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  7. NM_001376237.1 → NP_001363166.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 5-7, and 9-13, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  8. NM_001376238.1 → NP_001363167.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 2, 5-8, and 10-13, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  9. NM_001376239.1 → NP_001363168.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, 5-9, and 11-13, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  10. NM_001376240.1 → NP_001363169.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, 5-10, 12, and 13, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  11. NM_001376241.1 → NP_001363170.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 1, 2, 5-11, and 13, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  12. NM_001376242.1 → NP_001363171.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 1, 2, and 5-10-12, encodes isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  13. NM_001376243.1 → NP_001363172.1  E3 ubiquitin-protein ligase MARCHF7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cd16812
    Location:552 → 610
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  14. NM_001376244.1 → NP_001363173.1  E3 ubiquitin-protein ligase MARCHF7 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform e.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7Z5K0
    Conserved Domains (1) summary
    cd16812
    Location:552 → 610
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  15. NM_001376245.1 → NP_001363174.1  E3 ubiquitin-protein ligase MARCHF7 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform e.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7Z5K0
    Conserved Domains (1) summary
    cd16812
    Location:552 → 610
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  16. NM_001376246.1 → NP_001363175.1  E3 ubiquitin-protein ligase MARCHF7 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (2) summary
    cd00162
    Location:529 → 584
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:529 → 587
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  17. NM_001376247.1 → NP_001363176.1  E3 ubiquitin-protein ligase MARCHF7 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform g.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7Z5K0
    Conserved Domains (2) summary
    cd00162
    Location:496 → 551
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:496 → 554
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  18. NM_001376248.1 → NP_001363177.1  E3 ubiquitin-protein ligase MARCHF7 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform g.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7Z5K0
    Conserved Domains (2) summary
    cd00162
    Location:496 → 551
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:496 → 554
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  19. NM_001376249.1 → NP_001363178.1  E3 ubiquitin-protein ligase MARCHF7 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variants 21-23, encodes isoform h.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cd16812
    Location:423 → 481
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  20. NM_001376250.1 → NP_001363179.1  E3 ubiquitin-protein ligase MARCHF7 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variants 20, 22, and 23, encodes isoform h.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cd16812
    Location:423 → 481
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  21. NM_001376251.1 → NP_001363180.1  E3 ubiquitin-protein ligase MARCHF7 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variants 20, 21, and 23, encodes isoform h.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cd16812
    Location:423 → 481
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  22. NM_001376252.1 → NP_001363181.1  E3 ubiquitin-protein ligase MARCHF7 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variants 20-22, encodes isoform h.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cd16812
    Location:423 → 481
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  23. NM_001376253.1 → NP_001363182.1  E3 ubiquitin-protein ligase MARCHF7 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform i.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cd16812
    Location:423 → 481
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  24. NM_001376254.1 → NP_001363183.1  E3 ubiquitin-protein ligase MARCHF7 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform i.
    Source sequence(s)
    AC009961
    UniProtKB/TrEMBL
    B7ZAR7
    Conserved Domains (1) summary
    cd16812
    Location:423 → 481
    RING_CH-C4HC3_MARCH7; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)

  25. NM_001376255.1 → NP_001363184.1  E3 ubiquitin-protein ligase MARCHF7 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC009961
    Conserved Domains (2) summary
    cd00162
    Location:362 → 417
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:362 → 420
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  26. NM_022826.4 → NP_073737.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    See identical proteins and their annotated locations for NP_073737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-13 all encode the same isoform (a).
    Source sequence(s)
    AC009961, AI863394, AK222880, AK316382, BC003404, DA825046
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Related
    ENSP00000259050.3, ENST00000259050.8
    Conserved Domains (1) summary
    cl17238
    Location:552 → 610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. NR_164789.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961

  2. NR_164790.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961

  3. NR_164791.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961

  4. NR_164792.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961

  5. NR_164793.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961

  6. NR_164794.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961

  7. NR_164795.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    159712506..159771027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445513.1 → XP_047301469.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

  2. XM_047445518.1 → XP_047301474.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  3. XM_047445527.1 → XP_047301483.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  4. XM_047445516.1 → XP_047301472.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  5. XM_047445524.1 → XP_047301480.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  6. XM_047445517.1 → XP_047301473.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  7. XM_047445525.1 → XP_047301481.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  8. XM_047445530.1 → XP_047301486.1  E3 ubiquitin-protein ligase MARCHF7 isoform X4

    UniProtKB/TrEMBL
    F5H6W4

  9. XM_047445526.1 → XP_047301482.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  10. XM_017004721.2 → XP_016860210.1  E3 ubiquitin-protein ligase MARCHF7 isoform X4

    UniProtKB/TrEMBL
    B7Z5K0, F5H6W4
    Conserved Domains (1) summary
    smart00744
    Location:496 → 552
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  11. XM_047445508.1 → XP_047301464.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

  12. XM_047445521.1 → XP_047301477.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  13. XM_047445529.1 → XP_047301485.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  14. XM_047445519.1 → XP_047301475.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  15. XM_047445520.1 → XP_047301476.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  16. XM_047445528.1 → XP_047301484.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  17. XM_047445511.1 → XP_047301467.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

  18. XM_047445514.1 → XP_047301470.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

  19. XM_047445523.1 → XP_047301479.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  20. XM_047445515.1 → XP_047301471.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    UniProtKB/Swiss-Prot
    A8K9X1, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9, Q9H992

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    160169869..160228395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343405.1 → XP_054199380.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

  2. XM_054343409.1 → XP_054199384.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  3. XM_054343417.1 → XP_054199392.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  4. XM_054343407.1 → XP_054199382.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  5. XM_054343414.1 → XP_054199389.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  6. XM_054343408.1 → XP_054199383.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  7. XM_054343415.1 → XP_054199390.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  8. XM_054343421.1 → XP_054199396.1  E3 ubiquitin-protein ligase MARCHF7 isoform X4

  9. XM_054343416.1 → XP_054199391.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  10. XM_054343420.1 → XP_054199395.1  E3 ubiquitin-protein ligase MARCHF7 isoform X4

  11. XM_054343403.1 → XP_054199378.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

  12. XM_054343412.1 → XP_054199387.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  13. XM_054343419.1 → XP_054199394.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  14. XM_054343410.1 → XP_054199385.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  15. XM_054343411.1 → XP_054199386.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  16. XM_054343418.1 → XP_054199393.1  E3 ubiquitin-protein ligase MARCHF7 isoform X3

  17. XM_054343404.1 → XP_054199379.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

  18. XM_054343413.1 → XP_054199388.1  E3 ubiquitin-protein ligase MARCHF7 isoform X2

  19. XM_054343406.1 → XP_054199381.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H992.1 GenPept UniProtKB/Swiss-Prot:Q9H992

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