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MARCHF7 membrane associated ring-CH-type finger 7 [ Homo sapiens (human) ]

Gene ID: 64844, updated on 24-Dec-2019

Summary

Official Symbol
MARCHF7provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 7provided by HGNC
Primary source
HGNC:HGNC:17393
See related
Ensembl:ENSG00000136536 MIM:613334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXO; AXOT; MARCH7; RNF177; MARCH-VII
Summary
MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]
Expression
Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 28.8) and 25 other tissues See more
Orthologs

Genomic context

See MARCHF7 in Genome Data Viewer
Location:
2q24.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (159712494..159771027)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160568980..160625084)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene uncharacterized LOC643072 Neighboring gene RPS3A pseudogene 13 Neighboring gene LY75-CD302 readthrough Neighboring gene CD302 molecule Neighboring gene lymphocyte antigen 75 Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586F1122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MDM2/MDM4 family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCH7
Names
RING finger protein 177
RING-type E3 ubiquitin transferase MARCH7
axotrophin
membrane associated ring finger 7
membrane-associated RING finger protein 7
membrane-associated RING-CH protein VII
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
NP_001269734.1
NP_001269735.1
NP_001269736.1
NP_001363163.1
NP_001363164.1
NP_001363165.1
NP_001363166.1
NP_001363167.1
NP_001363168.1
NP_001363169.1
NP_001363170.1
NP_001363171.1
NP_001363172.1
NP_001363173.1
NP_001363174.1
NP_001363175.1
NP_001363176.1
NP_001363177.1
NP_001363178.1
NP_001363179.1
NP_001363180.1
NP_001363181.1
NP_001363182.1
NP_001363183.1
NP_001363184.1
NP_073737.1
XP_016860210.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282805.2NP_001269734.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    See identical proteins and their annotated locations for NP_001269734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 5-13 all encode the same isoform (a).
    Source sequence(s)
    AC009961, AI863394, AK292836, AK316382, BC003404
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Related
    ENSP00000386830.1, ENST00000409175.6
    Conserved Domains (1) summary
    cl17238
    Location:552610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. NM_001282806.2NP_001269735.1  E3 ubiquitin-protein ligase MARCH7 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009961
    Consensus CDS
    CCDS63038.1
    UniProtKB/Swiss-Prot
    Q9H992
    UniProtKB/TrEMBL
    B7Z5K0, B7ZAR7, F5H6W4
    Related
    ENSP00000442992.1, ENST00000539065.5
    Conserved Domains (1) summary
    smart00744
    Location:496552
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  3. NM_001282807.2NP_001269736.1  E3 ubiquitin-protein ligase MARCH7 isoform c

    See identical proteins and their annotated locations for NP_001269736.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009961, AI863394, AK302347, AK316382, BC003404
    Consensus CDS
    CCDS63039.1
    UniProtKB/Swiss-Prot
    Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Related
    ENSP00000387238.1, ENST00000409591.5
    Conserved Domains (1) summary
    smart00744
    Location:514570
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  4. NM_001376234.1NP_001363163.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, and 6-13, encodes isoform a.
    Source sequence(s)
    AC009961
  5. NM_001376235.1NP_001363164.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 5, and 7-13, encodes isoform a.
    Source sequence(s)
    AC009961
  6. NM_001376236.1NP_001363165.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 5, 6, and 8-13, encodes isoform a.
    Source sequence(s)
    AC009961
  7. NM_001376237.1NP_001363166.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 5-7, and 9-13, encodes isoform a.
    Source sequence(s)
    AC009961
  8. NM_001376238.1NP_001363167.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 2, 5-8, and 10-13, encodes isoform a.
    Source sequence(s)
    AC009961
  9. NM_001376239.1NP_001363168.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, 5-9, and 11-13, encodes isoform a.
    Source sequence(s)
    AC009961
  10. NM_001376240.1NP_001363169.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, 5-10, 12, and 13, encodes isoform a.
    Source sequence(s)
    AC009961
  11. NM_001376241.1NP_001363170.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 1, 2, 5-11, and 13, encodes isoform a.
    Source sequence(s)
    AC009961
  12. NM_001376242.1NP_001363171.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 1, 2, and 5-10-12, encodes isoform a.
    Source sequence(s)
    AC009961
  13. NM_001376243.1NP_001363172.1  E3 ubiquitin-protein ligase MARCH7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC009961
  14. NM_001376244.1NP_001363173.1  E3 ubiquitin-protein ligase MARCH7 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform e.
    Source sequence(s)
    AC009961
  15. NM_001376245.1NP_001363174.1  E3 ubiquitin-protein ligase MARCH7 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform e.
    Source sequence(s)
    AC009961
  16. NM_001376246.1NP_001363175.1  E3 ubiquitin-protein ligase MARCH7 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC009961
  17. NM_001376247.1NP_001363176.1  E3 ubiquitin-protein ligase MARCH7 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 19, encodes isoform g.
    Source sequence(s)
    AC009961
  18. NM_001376248.1NP_001363177.1  E3 ubiquitin-protein ligase MARCH7 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variant 18, encodes isoform g.
    Source sequence(s)
    AC009961
  19. NM_001376249.1NP_001363178.1  E3 ubiquitin-protein ligase MARCH7 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variants 21-23, encodes isoform h.
    Source sequence(s)
    AC009961
  20. NM_001376250.1NP_001363179.1  E3 ubiquitin-protein ligase MARCH7 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variants 20, 22, and 23, encodes isoform h.
    Source sequence(s)
    AC009961
  21. NM_001376251.1NP_001363180.1  E3 ubiquitin-protein ligase MARCH7 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variants 20, 21, and 23, encodes isoform h.
    Source sequence(s)
    AC009961
  22. NM_001376252.1NP_001363181.1  E3 ubiquitin-protein ligase MARCH7 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variants 20-22, encodes isoform h.
    Source sequence(s)
    AC009961
  23. NM_001376253.1NP_001363182.1  E3 ubiquitin-protein ligase MARCH7 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform i.
    Source sequence(s)
    AC009961
  24. NM_001376254.1NP_001363183.1  E3 ubiquitin-protein ligase MARCH7 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform i.
    Source sequence(s)
    AC009961
  25. NM_001376255.1NP_001363184.1  E3 ubiquitin-protein ligase MARCH7 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC009961
  26. NM_022826.4NP_073737.1  E3 ubiquitin-protein ligase MARCH7 isoform a

    See identical proteins and their annotated locations for NP_073737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-13 all encode the same isoform (a).
    Source sequence(s)
    AC009961, AI863394, AK222880, AK316382, BC003404, DA825046
    Consensus CDS
    CCDS2210.1
    UniProtKB/Swiss-Prot
    Q9H992
    UniProtKB/TrEMBL
    B7ZAR7
    Related
    ENSP00000259050.3, ENST00000259050.8
    Conserved Domains (1) summary
    cl17238
    Location:552610
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. NR_164789.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961
  2. NR_164790.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961
  3. NR_164791.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961
  4. NR_164792.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961
  5. NR_164793.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961
  6. NR_164794.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961
  7. NR_164795.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009961

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    159712494..159771027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004721.1XP_016860210.1  E3 ubiquitin-protein ligase MARCH7 isoform X4

    UniProtKB/TrEMBL
    F5H6W4
    Conserved Domains (1) summary
    smart00744
    Location:496552
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
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