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CEP85 centrosomal protein 85 [ Homo sapiens (human) ]

Gene ID: 64793, updated on 17-Jun-2019

Summary

Official Symbol
CEP85provided by HGNC
Official Full Name
centrosomal protein 85provided by HGNC
Primary source
HGNC:HGNC:25309
See related
Ensembl:ENSG00000130695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC21
Summary
This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 23.4), heart (RPKM 8.7) and 20 other tissues See more
Orthologs

Genomic context

See CEP85 in Genome Data Viewer
Location:
1p36.11
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (26234179..26278808)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26560644..26605529)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 16 pseudogene Neighboring gene uncharacterized LOC101928303 Neighboring gene mitochondrial ribosomal protein S6 pseudogene 1 Neighboring gene SH3 domain binding glutamate rich protein like 3 Neighboring gene UBX domain protein 11 Neighboring gene CD52 molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of centrosomal protein 85kDa (CEP85) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13976, FLJ22000, DKFZp434P232, DKFZp434L0117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centrosomal protein of 85 kDa
Names
centrosomal protein 85kDa
coiled-coil domain-containing protein 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281517.3NP_001268446.1  centrosomal protein of 85 kDa isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AK025653, AK299312, BC064528, DB079544
    Consensus CDS
    CCDS60038.1
    UniProtKB/Swiss-Prot
    Q6P2H3
    Related
    ENSP00000492362.2, ENST00000640292.2
    Conserved Domains (2) summary
    cl02488
    Location:360541
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl23720
    Location:486604
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001281518.3NP_001268447.1  centrosomal protein of 85 kDa isoform 3

    See identical proteins and their annotated locations for NP_001268447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR, lacks several exons in the 5' coding region, contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK025653, AL451139, BC019902, BC064528, DA666742
    UniProtKB/Swiss-Prot
    Q6P2H3
    Conserved Domains (1) summary
    TIGR04211
    Location:587
    SH3_and_anchor; SH3 domain protein
  3. NM_001319944.2NP_001306873.1  centrosomal protein of 85 kDa isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK024038, AK025653, AK299312, BC064528, DB079544
    Consensus CDS
    CCDS81285.1
    UniProtKB/Swiss-Prot
    Q6P2H3
    Related
    ENSP00000417002.3, ENST00000451429.7
    Conserved Domains (3) summary
    pfam05010
    Location:436642
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl02488
    Location:411592
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl23720
    Location:537655
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  4. NM_022778.5NP_073615.2  centrosomal protein of 85 kDa isoform 1

    See identical proteins and their annotated locations for NP_073615.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK025653, BC064528, DB079544
    Consensus CDS
    CCDS277.1
    UniProtKB/Swiss-Prot
    Q6P2H3
    Related
    ENSP00000252992.4, ENST00000252992.8
    Conserved Domains (2) summary
    pfam09726
    Location:124543
    Macoilin; Transmembrane protein
    cl25732
    Location:382657
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    26234179..26278808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002105.2XP_016857594.1  centrosomal protein of 85 kDa isoform X2

  2. XM_024449200.1XP_024304968.1  centrosomal protein of 85 kDa isoform X1

    Conserved Domains (2) summary
    pfam09726
    Location:124543
    Macoilin; Transmembrane protein
    cl25732
    Location:382657
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_024449198.1XP_024304966.1  centrosomal protein of 85 kDa isoform X1

    Conserved Domains (2) summary
    pfam09726
    Location:124543
    Macoilin; Transmembrane protein
    cl25732
    Location:382657
    SMC_N; RecF/RecN/SMC N terminal domain
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