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CEP85 centrosomal protein 85 [ Homo sapiens (human) ]

Gene ID: 64793, updated on 3-Nov-2024

Summary

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Official Symbol
CEP85provided by HGNC
Official Full Name
centrosomal protein 85provided by HGNC
Primary source
HGNC:HGNC:25309
See related
Ensembl:ENSG00000130695 MIM:618898; AllianceGenome:HGNC:25309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC21
Summary
This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 23.4), heart (RPKM 8.7) and 20 other tissues See more
Orthologs
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Genomic context

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See CEP85 in Genome Data Viewer
Location:
1p36.11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26234200..26278808)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26071614..26116296)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26560691..26605299)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26551137-26551642 Neighboring gene uncharacterized LOC124903882 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26551643-26552147 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26556108-26556276 Neighboring gene zona pellucida like domain containing 2, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 485 Neighboring gene uncharacterized LOC124904684 Neighboring gene MPRA-validated peak133 silencer Neighboring gene mitochondrial ribosomal protein S6 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:26602348-26603547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26606098-26606985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26606986-26607872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26610368-26610958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 487 Neighboring gene SH3 domain binding glutamate rich protein like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26616244-26617056 Neighboring gene UBX domain protein 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26617057-26617870 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:26629035-26630234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 493 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26644239-26644431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 495 Neighboring gene CD52 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration. Liu Y, et al. J Cell Sci, 2020 Apr 23. PMID 32107292, Free PMC Article
  2. Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly. Liu Y, et al. Nat Commun, 2018 Apr 30. PMID 29712910, Free PMC Article
  3. Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. Chen C, et al. J Cell Sci, 2015 Sep 1. PMID 26220856, Free PMC Article
  4. CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly. Gomez-Ferreria MA, et al. Cell Cycle, 2012 Oct 1. PMID 22895009, Free PMC Article
  5. A chemical tool for blue light-inducible proximity photo-crosslinking in live cells. Mishra PK, et al. Chem Sci, 2022 Jan 26. PMID 35211260, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.
    Title: Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.
  2. Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
    Title: Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
  3. Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC) to antagonize Nek2A
    Title: Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of centrosomal protein 85kDa (CEP85) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13976, FLJ22000, DKFZp434P232, DKFZp434L0117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centrosomal protein of 85 kDa
Names
centrosomal protein 85kDa
coiled-coil domain-containing protein 21

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281517.3 → NP_001268446.1  centrosomal protein of 85 kDa isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AK025653, AK299312, BC064528, DB079544
    Consensus CDS
    CCDS60038.1
    UniProtKB/Swiss-Prot
    Q6P2H3
    Related
    ENSP00000492362.2, ENST00000640292.2
    Conserved Domains (2) summary
    cl02488
    Location:360 → 541
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl23720
    Location:486 → 604
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_001281518.3 → NP_001268447.1  centrosomal protein of 85 kDa isoform 3

    See identical proteins and their annotated locations for NP_001268447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR, lacks several exons in the 5' coding region, contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK025653, AL451139, BC019902, BC064528, DA666742
    UniProtKB/Swiss-Prot
    Q6P2H3
    Related
    ENST00000469609.5
    Conserved Domains (1) summary
    TIGR04211
    Location:5 → 87
    SH3_and_anchor; SH3 domain protein

  3. NM_001319944.2 → NP_001306873.1  centrosomal protein of 85 kDa isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK024038, AK025653, AK299312, BC064528, DB079544
    Consensus CDS
    CCDS81285.1
    UniProtKB/Swiss-Prot
    Q6P2H3
    Related
    ENSP00000417002.3, ENST00000451429.8
    Conserved Domains (3) summary
    pfam05010
    Location:436 → 642
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl02488
    Location:411 → 592
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl23720
    Location:537 → 655
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. NM_022778.5 → NP_073615.2  centrosomal protein of 85 kDa isoform 1

    See identical proteins and their annotated locations for NP_073615.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK025653, BC064528, DB079544
    Consensus CDS
    CCDS277.1
    UniProtKB/Swiss-Prot
    B4DRL1, D3DPK4, F8W7K4, Q5VY68, Q5VY70, Q6P2H3, Q9H6Q1, Q9H828, Q9UF52
    Related
    ENSP00000252992.4, ENST00000252992.8
    Conserved Domains (2) summary
    pfam09726
    Location:124 → 543
    Macoilin; Transmembrane protein
    cl25732
    Location:382 → 657
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26234200..26278808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428051.1 → XP_047284007.1  centrosomal protein of 85 kDa isoform X2

  2. XM_017002105.3 → XP_016857594.1  centrosomal protein of 85 kDa isoform X3

  3. XM_024449200.2 → XP_024304968.1  centrosomal protein of 85 kDa isoform X1

    UniProtKB/Swiss-Prot
    B4DRL1, D3DPK4, F8W7K4, Q5VY68, Q5VY70, Q6P2H3, Q9H6Q1, Q9H828, Q9UF52
    Conserved Domains (2) summary
    pfam09726
    Location:124 → 543
    Macoilin; Transmembrane protein
    cl25732
    Location:382 → 657
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_047428052.1 → XP_047284008.1  centrosomal protein of 85 kDa isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    26071614..26116296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338304.1 → XP_054194279.1  centrosomal protein of 85 kDa isoform X2

  2. XM_054338305.1 → XP_054194280.1  centrosomal protein of 85 kDa isoform X3

  3. XM_054338303.1 → XP_054194278.1  centrosomal protein of 85 kDa isoform X1

    UniProtKB/Swiss-Prot
    B4DRL1, D3DPK4, F8W7K4, Q5VY68, Q5VY70, Q6P2H3, Q9H6Q1, Q9H828, Q9UF52

  4. XM_054338306.1 → XP_054194281.1  centrosomal protein of 85 kDa isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P2H3.1 GenPept UniProtKB/Swiss-Prot:Q6P2H3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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