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PCED1A PC-esterase domain containing 1A [ Homo sapiens (human) ]

Gene ID: 64773, updated on 5-Sep-2021

Summary

Official Symbol
PCED1Aprovided by HGNC
Official Full Name
PC-esterase domain containing 1Aprovided by HGNC
Primary source
HGNC:HGNC:16212
See related
Ensembl:ENSG00000132635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM113A; C20orf81; bA12M19.1
Summary
The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in spleen (RPKM 18.9), thyroid (RPKM 14.9) and 25 other tissues See more
Orthologs
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Genomic context

See PCED1A in Genome Data Viewer
Location:
20p13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (2835314..2841243, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2815960..2821797, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr20.196 Neighboring gene transmembrane protein 239 Neighboring gene VPS16 core subunit of CORVET and HOPS complexes Neighboring gene protein tyrosine phosphatase receptor type A Neighboring gene gonadotropin releasing hormone 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22376, FLJ42927, DKFZp547L054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
PC-esterase domain-containing protein 1A
Names
family with sequence similarity 113, member A
sarcoma antigen NY-SAR-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271168.2NP_001258097.1  PC-esterase domain-containing protein 1A isoform 2

    See identical proteins and their annotated locations for NP_001258097.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AA769290, AK026029, AK056353
    Consensus CDS
    CCDS59442.1
    UniProtKB/Swiss-Prot
    Q9H1Q7
    Related
    ENSP00000349334.3, ENST00000356872.7
    Conserved Domains (1) summary
    cd01842
    Location:34215
    SGNH_hydrolase_like_5; SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site ...
  2. NM_022760.6NP_073597.2  PC-esterase domain-containing protein 1A isoform 1

    See identical proteins and their annotated locations for NP_073597.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL161656
    Consensus CDS
    CCDS13035.1
    UniProtKB/Swiss-Prot
    Q9H1Q7
    Related
    ENSP00000353868.2, ENST00000360652.7
    Conserved Domains (1) summary
    cd01842
    Location:34266
    SGNH_hydrolase_like_5; SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    2835314..2841243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260804.2XP_005260861.1  PC-esterase domain-containing protein 1A isoform X1

    See identical proteins and their annotated locations for XP_005260861.1

    UniProtKB/Swiss-Prot
    Q9H1Q7
    Conserved Domains (1) summary
    cd01842
    Location:34266
    SGNH_hydrolase_like_5; SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site ...
  2. XM_005260805.3XP_005260862.1  PC-esterase domain-containing protein 1A isoform X2

    See identical proteins and their annotated locations for XP_005260862.1

    UniProtKB/Swiss-Prot
    Q9H1Q7
    Conserved Domains (1) summary
    cd01842
    Location:34215
    SGNH_hydrolase_like_5; SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site ...
  3. XM_005260806.4XP_005260863.1  PC-esterase domain-containing protein 1A isoform X3

    Conserved Domains (1) summary
    cd01842
    Location:34266
    SGNH_hydrolase_like_5; SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site ...

RNA

  1. XR_244222.4 RNA Sequence

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