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NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 [ Homo sapiens (human) ]

Gene ID: 64710, updated on 21-Dec-2019

Summary

Official Symbol
NUCKS1provided by HGNC
Official Full Name
nuclear casein kinase and cyclin dependent kinase substrate 1provided by HGNC
Primary source
HGNC:HGNC:29923
See related
Ensembl:ENSG00000069275 MIM:611912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JC7; NUCKS
Summary
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in brain (RPKM 77.7), thyroid (RPKM 69.9) and 25 other tissues See more
Orthologs

Genomic context

See NUCKS1 in Genome Data Viewer
Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (205712822..205750220, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205681947..205719372, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GABA type A receptor-associated protein pseudogene Neighboring gene ETS transcription factor ELK4 Neighboring gene solute carrier family 45 member 3 Neighboring gene uncharacterized LOC105371701 Neighboring gene uncharacterized LOC105371702 Neighboring gene RAB29, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
NHGRI GWA Catalog
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
NHGRI GWA Catalog
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
NHGRI GWA Catalog
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
NHGRI GWA Catalog
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
NHGRI GWA Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
NHGRI GWA Catalog
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
NHGRI GWA Catalog
Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.
NHGRI GWA Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat NUCKS1 enhances HIV-1 Tat-mediated transcriptional activation on the HIV-1 LTR, and knockdown of NUCKS1 by siRNA significantly reduces Tat-mediated transcriptional activation PubMed
tat HIV-1 Tat interacts directly with both ectopically expressed and endogenous NUCKS1 in HEK293 cells PubMed
capsid gag Overexpression of NUCKS1 moderately induces HIV-1 production with increased release of p24 without PMA stimulation in latently infected cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21480, FLJ32016, FLJ38536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to X-ray IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene conversion NAS
Non-traceable Author Statement
more info
PubMed 
interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation by host of RNA binding by virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation by host of viral RNA-binding transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation by host of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation by host of viral transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
 
release from viral latency IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication fork processing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Names
P1
nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate
potential LAG1 interactor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027548.1 RefSeqGene

    Range
    5063..42423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022731.5NP_073568.2  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

    See identical proteins and their annotated locations for NP_073568.2

    Status: REVIEWED

    Source sequence(s)
    AA760780, AB049824, AC119673, AK025133, AK095855, BC000805, BQ638451
    Consensus CDS
    CCDS30987.1
    UniProtKB/Swiss-Prot
    Q9H1E3
    Related
    ENSP00000356110.4, ENST00000367142.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    205712822..205750220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245453.1XP_005245510.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1

    See identical proteins and their annotated locations for XP_005245510.1

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