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NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 [ Homo sapiens (human) ]

Gene ID: 64710, updated on 5-May-2024

Summary

Official Symbol
NUCKS1provided by HGNC
Official Full Name
nuclear casein kinase and cyclin dependent kinase substrate 1provided by HGNC
Primary source
HGNC:HGNC:29923
See related
Ensembl:ENSG00000069275 MIM:611912; AllianceGenome:HGNC:29923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JC7; NUCKS
Summary
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in brain (RPKM 77.7), thyroid (RPKM 69.9) and 25 other tissues See more
Orthologs
NEW
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Genomic context

Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205712822..205750182, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204977487..205014861, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205681950..205719310, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GABA type A receptor-associated protein pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2383 Neighboring gene ETS transcription factor ELK4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205629205-205629793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205631113-205631667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205631668-205632223 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:205633133-205634332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2387 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205639145-205639706 Neighboring gene solute carrier family 45 member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205644516-205645016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205645017-205645517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1682 Neighboring gene uncharacterized LOC105371701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1747 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205657475-205658431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205662277-205662826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205670015-205670516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205670517-205671016 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205708952-205709557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205709558-205710164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205711268-205711871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205711872-205712474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2389 Neighboring gene RAB29, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205769142-205770092 Neighboring gene solute carrier family 41 member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:205779391-205779622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205782120-205782620

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
EBI GWAS Catalog
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
EBI GWAS Catalog
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
EBI GWAS Catalog
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
EBI GWAS Catalog
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
EBI GWAS Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
EBI GWAS Catalog
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
EBI GWAS Catalog
Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.
EBI GWAS Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat NUCKS1 enhances HIV-1 Tat-mediated transcriptional activation on the HIV-1 LTR, and knockdown of NUCKS1 by siRNA significantly reduces Tat-mediated transcriptional activation PubMed
tat HIV-1 Tat interacts directly with both ectopically expressed and endogenous NUCKS1 in HEK293 cells PubMed
capsid gag Overexpression of NUCKS1 moderately induces HIV-1 production with increased release of p24 without PMA stimulation in latently infected cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21480, FLJ32016, FLJ38536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding HDA PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to X-ray IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene conversion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in modulation by host of RNA binding by virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation by host of viral RNA-binding transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in modulation by host of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation by host of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation by host of viral transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in replication fork processing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Names
P1
nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate
potential LAG1 interactor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027548.1 RefSeqGene

    Range
    5063..42423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022731.5NP_073568.2  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

    See identical proteins and their annotated locations for NP_073568.2

    Status: REVIEWED

    Source sequence(s)
    AA760780, AB049824, AC119673, AK025133, AK095855, BC000805, BQ638451
    Consensus CDS
    CCDS30987.1
    UniProtKB/Swiss-Prot
    Q54AC0, Q5PXE7, Q9H1D6, Q9H1E3, Q9H723
    Related
    ENSP00000356110.4, ENST00000367142.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    205712822..205750182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245453.2XP_005245510.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1

    See identical proteins and their annotated locations for XP_005245510.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    204977487..205014861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338257.1XP_054194232.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1